Preoperative Chemotherapy May Not Influence the Remnant Liver Regenerations and Outcomes After Hepatectomy for Colorectal Liver Metastasis

2018 ◽  
Vol 42 (10) ◽  
pp. 3316-3330 ◽  
Author(s):  
Yoshihiro Inoue ◽  
Kensuke Fujii ◽  
Keitaro Tashiro ◽  
Masatsugu Ishii ◽  
Shinsuke Masubuchi ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis ◽  
Remnant Liver

Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Surgical Intervention ◽  
Liver Volume ◽  
Sigmoid Colon Cancer ◽  
Remnant Liver ◽  
Future Remnant Liver ◽  
The Right ◽  
Synchronous Colorectal Liver Metastasis ◽  
Right Hepatic Vein

A 72-year-old woman with a sigmoid colon cancer anda synchronous colorectal liver metastasis (CRLM), whichinvolved the right hepatic vein (RHV) and the inferiorvena cava (IVC), was referred to our hospital. Themetastatic lesion was diagnosed as initially unresectablebecause of its invasion into the confluence of theRHV and IVC. After she had undergone laparoscopicsigmoidectomy for the original tumor, she consequentlyhad 3 courses of modified 5-fluorouracil, leucovorin,and oxaliplatin (mFOLFOX6) plus cetuximab. Computedtomography revealed a partial response, and theconfluence of the RHV and IVC got free from cancerinvasion. After 3 additional courses of mFOLFOX6 pluscetuximab, preoperative percutaneous transhepaticportal vein embolization (PTPE) was performed tosecure the future remnant liver volume. Finally, a righthemihepatectomy was performed. The postoperativecourse was uneventful. The patient was dischargedfrom the hospital on postoperative day 13. She hadneither local recurrence nor distant metastasis 18 moafter the last surgical intervention. This multidisciplinarystrategy, consisting of conversion chemotherapy usingFOLFOX plus cetuximab and PTPE, could contributein facilitating curative hepatic resection for initiallyunresectable CRLM.Key words: Initially unresectable; Colorectal liver metastasis;Conversion chemotherapy; Cetuximab; Percutaneoustranshepatic portal vein embolization

scholarly journals Imaging in resectable colorectal liver metastasis patients with or without preoperative chemotherapy: results of the PROMETEO-01 study

2014 ◽  
Vol 111 (4) ◽  
pp. 667-673 ◽  
Author(s):  
F L Rojas Llimpe ◽  
F Di Fabio ◽  
G Ercolani ◽  
E Giampalma ◽  
A Cappelli ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis

Darbepoetin-α Promotes Cell Proliferation in Established Extrahepatic Colorectal Tumors after Major Hepatectomy

2015 ◽  
Vol 56 (1-2) ◽  
pp. 49-60
Author(s):  
Sebastian Senger ◽  
Otto Kollmar ◽  
Michael D. Menger ◽  
Kathrin Rupertus
Keyword(s):  
Cell Proliferation ◽  
Cell Migration ◽  
Liver Metastasis ◽  
Tumor Cell ◽  
Colorectal Liver Metastasis ◽  
Major Hepatectomy ◽  
Colorectal Metastases ◽  
Remnant Liver ◽  
Tumor Cell Proliferation ◽  
Tumor Cell Migration

Background: The glycoprotein hormone erythropoietin and its analogue darbepoetin-α (DPO) have been shown to reduce the risk of acute liver failure after major hepatectomy. However, previous experimental studies have also shown that DPO significantly enhances neovascularization and tumor cell proliferation in established colorectal liver metastasis in hepatectomized and nonhepatectomized mice. The present study now analyzes whether DPO influences cell proliferation and migration as well as vascularization and growth of established colorectal metastasis at extrahepatic sites after major hepatectomy. Methods: GFP-transfected CT26.WT colorectal cancer cells were implanted into dorsal skinfold chambers of syngeneic BALB/c mice. Five days after tumor cell implantation, the animals received a single dose of DPO (10 µg/kg body weight) or phosphate-buffered saline solution (PBS) intravenously. Additional animals received a 70% hepatectomy and DPO or PBS treatment. Tumor vascularization and growth as well as tumor cell migration, proliferation and apoptosis were studied repetitively over 14 days using intravital fluorescence microscopy, histology and immunohistochemistry. Results: DPO did not influence tumor cell migration and apoptosis. In addition, DPO did not stimulate tumor cell infiltration or vascularization; however, significantly increased tumor cell proliferation was detected in hepatectomized animals. Conclusion: DPO increases cell proliferation in established extrahepatic colorectal metastases after major hepatectomy. Thus, DPO may not be recommended to stimulate regeneration of the remnant liver after major hepatectomy for colorectal liver metastasis.

scholarly journals Preoperative Chemotherapy in Patients with Colorectal Liver Metastasis: Experience of Group of Gastrointestinal Tumours of Rimini

2014 ◽  
Vol 25 ◽  
pp. ii79
Author(s):  
Tamburini Emiliano ◽  
Veneroni Luigi ◽  
Rudnas Britt ◽  
Nicoletti Stefania Vittoria Luisa ◽  
Palini Gian Marco ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis ◽  
Gastrointestinal Tumours

The Relationship Between Postoperative Chemotherapy and Remnant Liver Regeneration and Outcomes After Hepatectomy for Colorectal Liver Metastasis

2018 ◽  
Vol 23 (10) ◽  
pp. 1973-1983
Author(s):  
Yoshihiro Inoue ◽  
Kensuke Fujii ◽  
Masatsugu Ishii ◽  
Syuji Kagota ◽  
Hiroki Hamamoto ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Liver Regeneration ◽  
Colorectal Liver Metastasis ◽  
Postoperative Chemotherapy ◽  
Remnant Liver ◽  
The Relationship

The feasibility and potential benefit of preoperative chemotherapy for colorectal liver metastasis (CLM): a single-centered retrospective study

Surgery Today ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. 1154-1161 ◽  
Author(s):  
Kozo Kataoka ◽  
Akiyoshi Kanazawa ◽  
Akio Nakajima ◽  
Ayane Yamaguchi ◽  
Akira Arimoto ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis ◽  
Potential Benefit

Prognostic influence of hepatic margin after resection of colorectal liver metastasis: role of modern preoperative chemotherapy

2017 ◽  
Vol 33 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Frank Makowiec ◽  
Peter Bronsert ◽  
Andrea Klock ◽  
Ulrich T. Hopt ◽  
Hannes P Neeff
Keyword(s):  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis

scholarly journals Correlation between CT morphologic appearance and histologic findings in colorectal liver metastasis after preoperative chemotherapy

2018 ◽  
Vol 43 (11) ◽  
pp. 2991-3000 ◽  
Author(s):  
Kazuyuki Ishida ◽  
Akio Tamura ◽  
Kenichi Kato ◽  
Noriyuki Uesugi ◽  
Mitsumasa Osakabe ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastasis ◽  
Morphologic Appearance
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