scholarly journals Evaluation of hepcidin as a biomarker for the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease

2018 ◽  
Vol 9 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Ephraim Chikwanda ◽  
Victor Daka ◽  
Marah Simakando ◽  
Sumbukeni Kowa ◽  
Trevor Kaile
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Diagnostic Value ◽  
World Health ◽  
Standard Case ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Serum Hepcidin

Background: Anaemia affects approximately 1.62 billion people globally corresponding to 24.8% of the world’s population. Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are the most common forms of anaemia. A hormone produced by the liver, hepcidin, is the primary regulator of iron homeostasis and its production increases in ACD and decreases in IDA. Usually, ACD and IDA coexist and sometimes look identical on peripheral blood smears.Aims and Objectives: The current study aims to evaluate the diagnostic value of hepcidin to predict ACD from IDA as well as the diagnostic value of hepcidin to predict ACD from a combination of IDA and ACD.Materials and Methods: Specimens presenting with haematological indices suggestive of IDA and/or ACD following World Health Organisation (WHO) standard case definitions were identified among samples coming to the Haematology laboratory for routine investigations. Serum hepcidin, serum ferritin, serum iron and total iron binding capacity (TIBC) were assessed. Demographic data was obtained from specimen requisition forms.Results: Of the 66 participants, 62.1% (n = 41) were females. IDA was more common among females (36.4%) than males (6.1%) while ACD was more common in males (19.7%) than females (12.1%). Iron Deficiency Anaemia participants had significantly lower hepcidin levels than ACD (p<0.001). There was a significant positive correlation between serum hepcidin and serum ferritin levels (p < 0.001).Conclusion: We found that IDA participants had significantly lower hepcidin levels than ACD and IDA/ACD combined. Therefore, serum hepcidin could be considered in diagnosing and distinguishing ACD from IDA or IDA/ACD as it also had high diagnostic sensitivity and specificity compared to other markers.Asian Journal of Medical Sciences Vol.9(1) 2018 15-20

scholarly journals Ferritin and iron studies in anaemia and chronic disease

2016 ◽  
Vol 54 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ying Y Peng ◽  
James Uprichard
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Deficiency Anaemia ◽  
Iron Homeostasis ◽  
Red Cells ◽  
Pivotal Role ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Common Causes

Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia and the anaemia of chronic disease are the two most common causes of anaemia worldwide;1 iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential not only for diagnosis but also in guiding management. This review will primarily focus on iron deficiency anaemia and anaemia of chronic disease; however, iron overload in anaemia will also be briefly discussed.

Haematology

2012 ◽  
pp. 451-464
Author(s):  
Lesley K Bowker ◽  
James D Price ◽  
Sarah C Smith
Keyword(s):  
Multiple Myeloma ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Older People ◽  
Myelodysplastic Syndrome ◽  
Iron Deficiency Anaemia ◽  
Macrocytic Anaemia ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Haematopoietic System

The ageing haematopoietic system 452 Investigating anaemia in older people 453 Iron deficiency anaemia: diagnosis 454 HOW TO . . . Investigate iron deficiency anaemia 455 Iron deficiency anaemia: treatment 456 Macrocytic anaemia 457 Anaemia of chronic disease 458 Paraproteinaemias 459 Multiple myeloma 460 Myelodysplasia and myelodysplastic syndrome ...

scholarly journals The Value of Soluble Transferrin Receptor and Soluble Transferrin Receptor-ferritin Index in Discriminating Iron Deficiency Anaemia from Anaemia of Chronic Disease in Patients With Rheumatoid Arthritis

2019 ◽  
Vol 13 (1) ◽  
pp. 9-14
Author(s):  
Haithem A. Al-Rubaie ◽  
Israa M. Al-Bayaa ◽  
Yassmin A. Al-Amiri
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Soluble Form ◽  
Soluble Transferrin Receptor ◽  
Deficiency Anaemia ◽  
Inflammatory Status ◽  
Anaemia Of Chronic Disease

Background:Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA) where anaemia of chronic disease (ACD) and iron deficiency anaemia (IDA) are the two most frequent types. The distinction between these two types of anaemia has always been challenging requiring sophisticated techniques. Serum transferrin receptor (sTfR) a truncated soluble form of the transferrin receptor is one of the parameters that is influenced by the Iron content and supply to the erythrons and is not affected by inflammatory status and therefore the use of the sTfR/log ferritin (sTfR-F) index can be a reliable indicator of functional iron deficiency.Aim of the study:This study aims to evaluate the usefulness of sTfR and sTfR-F index in discriminating the most common types of anaemia in patients with RA.Patients and methods:The study included 50 patients with RA and 30 healthy subjects as a control group. Complete blood picture, C-reactive protein, serum Iron, unsaturated iron binding capacity, sTfR and serum ferritin were tested.Results and Conclusion:anaemia was present in 34/50 patients; 19 patients had ACD, 9 had ACD/IDA and only 6 patients had IDA. Both the sTfR and the sTfR-F index showed a significant difference between anaemia groups (P values = 0.037 and 0.001, respectively). sTfR-F index has shown to be a very useful parameter that can discriminate efficiently between IDA and ACD and between ACD and ACD/IDA in patients with RA.

scholarly journals Suitability of soluble transferrin receptor for the clinical diagnosis of different types of anaemia in children

2002 ◽  
Vol 8 (2-3) ◽  
pp. 298-307
Author(s):  
L. Ragab ◽  
H. A. Ibrahim ◽  
A. S. Eid ◽  
T. Kotb ◽  
M. F. Konsowa
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Iron Status ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Egyptian Children ◽  
Different Types ◽  
Patient Groups

We evaluated the ability of serum transferrin receptor [sTFR] to identify different types of anaemia in children. Thus 150 Egyptian children suffering from anaemia [iron deficiency anaemia, anaemia of chronic disease and beta-thalassaemia] were enrolled, together with 50 controls. There was a significant increase in the mean levels of sTFR in the groups with iron deficiency anaemia and thalassaemia, and a significant decrease in mean sTFR levels in the group with anaemia of chronic disease. Serum ferritin levels were significantly higher in all patient groups except the group with iron deficiency anaemia. There were also significant correlations between the sTFR and sTFR/log ferritin ratio [sTFR-F index] and different indices of iron status and of erythropoiesis. The sTFR-F index could be used as a diagnostic or screening tool for iron deficiency anaemia, anaemia of chronic disease and thalassaemia.

Haematology

2018 ◽  
Author(s):  
Lesley K. Bowker ◽  
James D. Price ◽  
Ku Shah ◽  
Sarah C. Smith
Keyword(s):  
Multiple Myeloma ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Myelodysplastic Syndrome ◽  
Iron Deficiency Anaemia ◽  
Lymphocytic Leukaemia ◽  
Macrocytic Anaemia ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Haematopoietic System

This chapter provides information on the ageing haematopoietic system, investigating anaemia in older people, diagnosis of iron deficiency anaemia, treatment of iron deficiency anaemia, macrocytic anaemia, anaemia of chronic disease, paraproteinaemias, multiple myeloma, myelodysplasia and myelodysplastic syndrome, and chronic lymphocytic leukaemia.

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