scholarly journals Changes in Heart Rate Variability and Glycosylated Hemoglobin in Prediabetics and Type 2 Diabetes Mellitus

2017 ◽  
Vol 5 (1) ◽  
pp. 15-18
Author(s):  
A.K. Mishra ◽  
R.K. Jha ◽  
B.K. Kapoor
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Glycosylated Hemoglobin ◽  
Disease Process ◽  
Significant Rise ◽  
Parasympathetic Activity ◽  
Cardiac Autonomic Neuropathy

Background People with diabetes mellitus (DM) suffer from cardiac autonomic neuropathy (CAN), this may remain subclinical and reduced heart rate variability (HRV) is noticed as its early indicator.Objective The present study was undertaken to investigate the changes in heart rate variability and glycosylated hemoglobin (HbA1C) in (i) pre-diabetics, (ii) diabetics, (iii) non-diabetic subjects.Methods The present study enrolled 30 patients, diagnosed with type 2 DM and 30 prediabetic subjects aged between 30-60 years and compared with its aged matched healthy controls. In HRV, Time Domain (TD) parameters used were: SDNN, rMSSD, NN50 and pNN50%; and Frequency Domain (FD) parameters were: low frequency (LF), high frequency (HF) and LF/HF ratio. Glycosylated Hb and random blood sugar were measured.Results In HRV, though the time domain measures that reflects parasympathetic activity decreased was insignificant in the cases, the FD parameters such as LF reflecting activities of both division of ANS and HF reflecting only parasympathetic activity were found significantly reduced in diabetes and then control, whereas LF/HF ratio was increased only in diabetic patient (p<0.001) indicating sympathovagal imbalance. Rise in HbA1C was insignificant in prediabetic compared to control, which was observed significant only in diabetic (p< 0.001) patients.Conclusion Findings of the present study suggest that though HbA1c is an indicator of sustained hyperglycemia for monitoring glycemic level, even before its significant rise in plasma, alteration of sympatho-vagal balance over heart begins early in the disease process of diabetes.Journal of Advances in Internal Medicine 2016;05(01):15-18

Stratification of the Type 2 Diabetes Mellitus Based on Heart Rate Variability Parameters in Elderly Women at Rest

2020 ◽  
Vol 7 (3) ◽  
pp. 01-08
Author(s):  
Wollner Materko ◽  
Daianne Freires Fernandes ◽  
Francineide Pereira da Silva Pena
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Predictive Value ◽  
Elderly Women ◽  
Sampling Rate ◽  
Cardiac Autonomic Neuropathy

Cardiac autonomic neuropathy in type 2 diabetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. The purpose of the present study was to stratify the T2DM using a logistic model based on parameters derived from heart rate variability (HRV). This study was designed as a cross-sectional study of consisted of thirty elderly women subjects 60 to 70 yrs of age with diagnosed with T2DM (N = 15) and healthy (N = 15). All subjects were instructed to lie in the supine position for 5 min at rest while breathing normally with a heart rate monitor Polar RS810 working at a sampling rate of 1000 Hz was used to record RR intervals (RRi). The HRV analysis in the time domain was performed to obtain the classical parameters pNN50, SDNN, RMSSD and MeanRRi and, subsequently, re-sampling procedure to bootstrapping based on 1000 samples. The model for predicting T2DM was obtained by backward stepwise multivariate logistic regression assuming as independent variable MeanRRi. This model presented 0.80 positive predictive value, 0.73 negative predictive value and 0.76 total accuracy. In conclusion, the use of the proposed MeanRRi parameter measured at rest seems to be able to stratify the T2DM in elderly women. The benefits of HRV monitoring the severity of T2DM should be potential as a reliable and non-invasive.

scholarly journals EVALUATION OF AUTONOMIC DYSFUNCTION BY HEART RATE VARIABILITY ANALYSIS IN TYPE 2 DIABETES MELLITUS

2016 ◽  
Vol 10 (1) ◽  
pp. 309
Author(s):  
Phurpa Nil Nil ◽  
Sultana - Ferdousi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Autonomic Neuropathy ◽  
Autonomic Dysfunction ◽  
Cardiac Autonomic Neuropathy ◽  
Heart Rate Variability Analysis

ABSTRACTObjective: Cardiac autonomic neuropathy (CAN) is a severe and common, yet highly underdiagnosed, complication of Type 2 diabetes mellitus(T2DM). Subclinical CAN may have reduced heart rate variability (HRV) but normal Ewing battery test. This study was performed to evaluate theimportance of 5 minutes HRV for the detection of autonomic dysfunction in T2DM without (CAN-T2DM).Methods: This cross-sectional observational study was conducted at the Department of Physiology, Bangabandhu Sheikh Mujib Medical University(BSMMU) on 30 recently diagnosed T2DM (RT2DM) and 54 long-term CAN-male T2DM patients (LT2DM), aged 45-55 years, from the EndocrinologyOut Patient Department of BSMMU, Dhaka. 30 age and body mass index matched apparently healthy male subjects were control. Ewing battery testwas used to rule out CAN positive T2DM. HRV data were recorded by a polyrite-D and analyzed by software. HRV was assessed by time domainmethod. For statistical analysis, ANOVA and unpaired t-test were used.Results: Mean RR, standard deviation of NN intervals (SDNN) (p<0.05), and root mean square of the successive differences (RMSSD) were significantly(p<0.001) lower, and mean HR and SDNN/RMSSD were (p<0.001) significantly higher in LT2DM compared to RT2DM and control. In addition, SDNNwas also significantly (p<0.05) lower in RT2DM than that of control.Conclusions: Results conclude that autonomic dysfunction may occur in both LT2DM and RT2DM patients without neuropathy and 5 minutes HRVtest is an important tool for detecting subclinical CAN.Keywords: Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Heart rate variability.

scholarly journals Cardiac Autonomic Neuropathy in Diabetes Mellitus Patients – Are We Aware of the Consequences?

2020 ◽  
Vol 66 (1) ◽  
pp. 3-8
Author(s):  
Anca Motataianu ◽  
Laura Iulia Barcutean ◽  
Smaranda Maier ◽  
Adrian Balasa ◽  
Adina Stoian
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Long Term Effects

AbstractCardiovascular autonomic neuropathy is the most frequent clinical form of autonomous diabetic neuropathy and appears secondary to cardiac autonomous fibre involvement, actively involved in cardiac rhythm impairment. Type 2 diabetes mellitus patients can present cardiac autonomic neuropathy early in the disease. Autonomous nerve function in DM patients should be assessed as early as the diagnosis is set in order to establish the optimal therapeutic strategy. The most frequent cardio-vagal test used is heart rate variability. An abnormal heart rate variability in the presence of orthostatic arterial hypotension indicates a severe cardiac autonomic neuropathy diagnosis. The development of cardiac autonomic neuropathy is subjected to glycaemic control, duration of the disease and associated risk factors. The glycaemic control is extremely important, especially early in the disease. Therefore, a poor glycaemic control carries unfavourable long-term effects, despite an ulterior optimal control, a phenomenon named “hyperglycaemic memory”. In type 2 diabetes mellitus patients, the association of cardiac autonomic neuropathy with intensive glycaemic control increases the mortality rate, due to the fact, that, secondary to autonomous impairment, the patients do not present the typical symptoms associated with hypoglycaemia. Stratifying the cardiac autonomic neuropathy aids the clinician in assessing the morbidity and mortality risk of diabetes mellitus patients, because it is an independent risk factor for mortality, associated with silent myocardial infarctions and the risk of sudden death.

scholarly journals Heart rate variability evaluation in the assessment of cardiac autonomic neuropathy in patients with type 2 diabetes

Cor et Vasa ◽  
2018 ◽  
Vol 60 (4) ◽  
pp. e335-e344 ◽  
Author(s):  
Rudolf Metelka ◽  
Lubica Cibičková ◽  
Jaromíra Gajdová ◽  
Ondřej Krystyník
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy
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