scholarly journals Ovarian Adult Granulosa Cell Tumor – a rare case report

2018 ◽  
Vol 13 (1) ◽  
pp. 57-60
Author(s):  
Rijuta Joshi ◽  
Gehanath Baral ◽  
Karishma Malla
Keyword(s):  
Granulosa Cell ◽  
Abdominal Mass ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Late Recurrence ◽  
Abdominal Hysterectomy ◽  
Cell Tumor ◽  
Rare Case Report ◽  
Stage Ia ◽  
Post Menopausal

Introduction: Adult granulosa cell tumor is a rare tumor which accounts for 1% of all ovarian tumors.  They usually present with postmenopausal bleeding and abdominal mass. Inhibin is used as the tumor marker.Case: A 76 years multiparous post-menopausal women presented with vaginal bleeding for past three years and  painless  huge mass in lower abdomen.  She underwent total abdominal hysterectomy with bilateral salphingo-oophorectomy with bilateral pelvic lymphnode dissection with appendectomy. Histopathology showed the adult granulosa cell tumor with few mitosis, Stage IA. Her postoperative period was uneventful.Conclusion: Surgery is the mainstay of treatment of granulosa cell tumor and chemotherapy is indicated in advanced cases. Although they have better prognosis, life-long follow up is advised to detect late recurrence.

scholarly journals Granulosa cell tumor complicated by torsion, rupture and hemoperitoneum

2021 ◽  
Vol 10 (6) ◽  
pp. 2489
Author(s):  
Kripa Sherchan
Keyword(s):  
Postmenopausal Woman ◽  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Vaginal Bleeding ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Cell Tumor ◽  
Primary Therapy ◽  
Malignant Ovarian Tumor

Granulosa cell tumor, a sex cord stromal estrogen secreting tumor presents with vaginal bleeding and is seen in all ages. It accounts for <5% of all ovarian neoplasm. We reported a rare case of granulosa cell tumor in a postmenopausal woman undergoing staging laparotomy with total abdominal hysterectomy and bilateral salpingo-oopherectomy for malignant ovarian tumor, which was complicated by torsion, rupture and hemorrhagic ascitis. Any ovarian tumor with vaginal bleeding should arouse suspicion of granulosa cell tumor in the background of postmenopausal woman. For most patients, surgery alone is sufficient primary therapy, Radiation and chemotherapy are reserved for the treatment of recurrent or metastatic disease.

scholarly journals Three Different Ways to Miss a Granulosa Cell Tumor – A Lesson to be Learne

2021 ◽  
Vol 6 (3) ◽  
pp. 345-348
Author(s):  
Neethu Puthalon Kunnath ◽  
Sony Nanda ◽  
Janmejaya Mohapatra
Keyword(s):  
Endometrial Carcinoma ◽  
Granulosa Cell ◽  
Frozen Section ◽  
Granulosa Cell Tumor ◽  
Total Abdominal Hysterectomy ◽  
Late Recurrence ◽  
Cell Tumor ◽  
Low Grade ◽  
Biological Behaviour ◽  
Operative Recovery

Granulosa cell tumours (GCTs) account for approximately 70% of malignant sex-cord stromal tumors but are still uncommon and comprise only 2–5% of all ovarian neoplasms. They are classified as adult and juvenile GCTs. These are often low grade malignancies and are usually diagnosed in early stages, but with an potential for late recurrence. Case 1: A 51-year woman with c/o PMB with biopsy showing endometrial polyp. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy (TAH BSO) with omental biopsy after intraoperative pathology confirmation of a Adult granulosa cell tumor (AGCT) of the ovary. She had a good post-operative recovery and was advised for regular and long term follow up. Case 2: A 63-year woman c/o PMB with an adult granulosa cell tumor that initially presented as endometrial hyperplasia on biopsy. She underwent a TAH BSO and omental biopsy after intraop frozen section confirmed of AGCT of the ovary. She had an uneventful post-operative recovery. Case 3: A 68-year womanwith an AGCT that was initially treated as endometrial carcinoma. She underwent a Comprehensive Surgical Staging due to initial misdiagnosis of endometrial carcinoma. Her final biopsy report showed it to be a granulosa cell tumor of the ovary and adenocarcinoma of the endometrium. She had a good post-operative recovery and is being followed up till now. The multifaceted presentations with its erratic biological behaviour coupled with late recurrences are diagnostic pitfalls necessitating a high degree of suspicion for accurate clinical diagnosis.

scholarly journals Multiple recurrence of granulosa cell tumor of the ovary: A case report and literature review

2016 ◽  
Author(s):  
Varkha Chandra ◽  
Sandhya Jain ◽  
Neerja Goel ◽  
Bindia Gupta ◽  
Shalini Rajaram
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Adnexal Mass ◽  
Malignant Tumors ◽  
Abdominal Mass ◽  
Pelvic Mass ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Surgical Staging ◽  
Granulosa Cell Tumors

Introduction: Granulosa cell tumors comprise approximately 5% of all ovarian malignancy and account for 70% of malignant sex cord stromal tumors. Granulosa cell tumors have been diagnosed from infancy, the peak incidence being perimenopausal age. The potential of malignancy of these tumors is low, recurrences are often late and found in 10-33% of cases. Case Report: A 32-year-old P1L1 presented with large abdominal mass for which she underwent staging laparotomy with debulking surgery. She was a known case of granulosa cell tumor in the past and had undergone three laparotomies, along with chemotherapy. At the age of 13 yrs, she was diagnosed with a stage IA granulosa cell tumor (GCT) of the ovary first time. She underwent surgical staging and removal of left sided adnexal mass, after which she was asymptomatic for 7 years. In 2003 she again presented with lump abdomen for which she underwent resection of adnexal mass, histopathology was consistent with recurrent GCT. After second surgery she also received two cycles of chemotherapy. Despite adjuvant chemotherapy, patient presented again after three years in 2006 with adnexal mass and was found to have a third recurrence. At that time, she received 6 cycles of chemotherapy and the mass regressed. Meanwhile she got married and had one child. After four year in 2010 she again presented with lump abdomen and she underwent surgical staging, total abdominal hysterectomy with right salphingo ophorectomy along with removal of mass. After five year in 2015 she again presented with lump abdomen; there was a large pelvic mass which was removed and patient referred for chemotherapy. Discussion: GCTS which a rare malignant tumors of ovary tend to be associated with late recurrences. Although most recurrences occurs within 10 years after initial diagnosis, there are occasional reports of recurrences after10 years. We experienced the rare case of a patient who relapsed multiple times over 20 years, despite surgical and targeted treatment. Conclusion: The long history of granulosa cell tumor highlights the importance of extended follow up of the patient.

Late recurrence of juvenile granulosa cell tumor of the ovary

2004 ◽  
Vol 191 (1) ◽  
pp. 366-367 ◽  
Author(s):  
Stephen D Frausto ◽  
John P Geisler ◽  
Mavis S Fletcher ◽  
Anil K Sood
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Late Recurrence ◽  
Cell Tumor ◽  
Juvenile Granulosa Cell Tumor

scholarly journals Testicular Adult Type Granulosa Cell Tumor: A Very Rare Case Report and Review of Literature

2017 ◽  
Vol 1 (1) ◽  
pp. 12-14 ◽  
Author(s):  
Wei-Chieh Chen ◽  
◽  
Yun-Ho Lin ◽  
Shauh-Der Yeh ◽  
Chien-Chih Wu ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Rare Case ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of Literature ◽  
Adult Type ◽  
Rare Case Report

scholarly journals Primary granulosa cell tumor of cerebellum: A rare case report

2021 ◽  
Vol 23 ◽  
pp. 100992
Author(s):  
Sunil Rauniyar ◽  
Zhigang Shen ◽  
Lei Wang ◽  
Jia Gu ◽  
Mei Pengjin ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Rare Case ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Rare Case Report

scholarly journals Granulosa Cell Tumor Of The Ovary – An Incidental Finding During Caesarean Section – A Rare Case Report

2015 ◽  
Vol 12 (1) ◽  
pp. 60-63
Author(s):  
J Roy ◽  
AS Babu
Keyword(s):  
Caesarean Section ◽  
Granulosa Cell ◽  
Incidental Finding ◽  
Treatment Plan ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Teratoma ◽  
Borderline Tumor ◽  
Rare Case Report

Approximately one-fourth of the ovarian neoplasms and cysts are diagnosed incidentally during caesarean section. The possibility of borderline tumor or cancer should be considered although existence of ovarian malignancy in pregnancy is rare. We report a case of a rare solid malignant tumor of the ovary incidentally found during caesarean section. Intraoperatively, it was thought to be a variant of the common ovarian teratoma. Ovariectomy was done but histopathology revealed it to be granulosa cell tumor. The diagnosis changed the prognosis and future treatment plan drastically. Equipped with this knowledge physicians can be made aware of the existence of this little-known ovarian neoplasm along with its rare association with pregnancy. Also one can better manage, counsel and follow-up the patients after delivery, given the knowledge of the tumours’ inevitable malignant potential and its high incidence of recurrence.Kathmandu University Medical Journal Vol.12(1) 2014: 60-63

Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary

2005 ◽  
Vol 156 (1) ◽  
pp. 83-85 ◽  
Author(s):  
Samuel K. Caughron ◽  
Julia A. Bridge ◽  
Chhanda B. Bewtra ◽  
William J. Hunter ◽  
Marilu Nelson ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Late Recurrence ◽  
Cell Tumor ◽  
Diagnostic Aid

scholarly journals Biphasic Malignant Testicular Sex Cord-Stromal Tumor in a Cotton-top Tamarin (Saguinus oedipus) with Review of the Literature

2008 ◽  
Vol 45 (6) ◽  
pp. 922-927 ◽  
Author(s):  
J. H. Yearley ◽  
N. King ◽  
X. Liu ◽  
E. H. Curran ◽  
S. P. O'Neil
Keyword(s):  
Granulosa Cell ◽  
Abdominal Mass ◽  
Granulosa Cell Tumor ◽  
Needle Aspiration ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Histologic Examination ◽  
Saguinus Oedipus ◽  
Abdominal Tumor ◽  
Sex Cord Stromal Tumor

A 20–year old male cotton-top tamarin ( Saguinus oedipus) was presented with unilateral enlargement of an intrascrotal testicle. Fine-needle aspiration cytology demonstrated a neoplastic population with Call-Exner-like bodies and features of malignancy. The animal was castrated, and histologic examination revealed a biphasic sex cord-stromal tumor, with one region resembling Sertoli-cell tumor and one region resembling granulosa-cell tumor, with extensive microfollicular pattern and many Call-Exner bodies. Eight months after castration, the animal was euthanized on discovery of a caudal abdominal mass that displaced organs, was highly infiltrative, and extended into the paravertebral musculature with lysis of vertebral bone. Metastases to lymph node and lung were also present. Histologic examination of the abdominal tumor showed multifocal formation of Call-Exner bodies in an otherwise highly dedifferentiated population. Positive immunolabeling for alpha inhibin confirmed the sex cord-stromal origin of the abdominal and paravertebral tumor masses. This case has similarities to malignant testicular granulosa-cell tumor of humans.

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