Primary Malignant Melanoma of Uterine Cervix

Primary malignant melanoma of cervix (PMMC) is rare and aggressive cancer of uterine cervix. It presented as vaginal discharge, post coital bleding and blackish cervical growth that was biopsied and radical hysterectomy performed immediately after getting the histopathological diagnosis at stage-1B2 (FIGO staging, 2018). Post-treatment, she was recurrence free at nine months of regular follow up visit. Keywords: cervix, malignant, melanoma, primary

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Primary malignant melanoma of the uterine cervix treated with radical surgery and adjuvant chemo-radiation using temozolomide and cisplatin: a case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193570 ◽

2019 ◽

Vol 8 (8) ◽

pp. 3387

Author(s):

Goter Doke ◽

Shyam Tsering ◽

Hage Nobin ◽

Dacto Gara

Keyword(s):

Case Report ◽

Malignant Melanoma ◽

Uterine Cervix ◽

Radical Hysterectomy ◽

Vaginal Bleeding ◽

Radical Surgery ◽

Pelvic Lymphadenectomy ◽

Primary Malignant Melanoma ◽

Rare Neoplasm

Primary malignant melanoma of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is very poor. Herein, authors report a case of 45-year-old woman who presented with vaginal bleeding for one months and examination showed an exophytic, 6 cm polypoid blackish-pigmented tumor on the cervix involving vaginal fornix. She underwent abdominal radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy and further received adjuvant concurrent chemo-radiation with cisplatin (CDDP) and temozolamide but died 7 months after surgery.

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Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma?

Neurosurgical FOCUS ◽

10.3171/foc.2006.21.6.3 ◽

2006 ◽

Vol 21 (6) ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Ahmet Şengöz ◽

Erol Taşdemiroğlu ◽

Halit Togay

Keyword(s):

Malignant Melanoma ◽

Nerve Root ◽

Clear Cell ◽

Clear Cell Sarcoma ◽

Histopathological Diagnosis ◽

Total Resection ◽

Cell Sarcoma ◽

Melanotic Schwannoma ◽

Psammomatous Melanotic Schwannoma

✓The authors present a case of clear cell sarcoma (CCS) in which the tumor originated in the S-1 nerve root and had been previously diagnosed as psammomatous melanotic schwannoma (PMS). This is the third case of a spinal nerve root origin for CCS reported in the English-language literature. The similar histogenesis of CCS and malignant melanoma supports the hypothesis that biological agents or immunotherapy are potentially important areas of investigation. The patient underwent S1–3 laminectomy and gross-total resection of the mass lesion. The border of the resection was extended 1 cm distal to the tumor margin. The postoperative period was uneventful. The new histopathological diagnosis was CCS (malignant melanoma of soft tissue). Despite total resection, the patient returned with disseminated disease at the 18-month follow-up visit. His follow-up magnetic resonance image of the lumbar spine revealed sacral L5–S3 involvement of the vertebral bodies along with disseminated cauda equina seeding. A CCS originating from peripheral nerves is quite rare. The histopathological and immunohistochemical appearance of CCSs resembles those of PMSs. Surgery should be the first choice of treatment.

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Primary Malignant Melanoma of the Uterine Cervix

International Journal of Gynecological Pathology ◽

10.1097/00004347-199907000-00013 ◽

1999 ◽

Vol 18 (3) ◽

pp. 265-273 ◽

Cited By ~ 44

Author(s):

Katherine C. Clark ◽

William R. Butz ◽

Marc R. Hapke

Keyword(s):

Malignant Melanoma ◽

Uterine Cervix ◽

Primary Malignant Melanoma

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Primary malignant melanoma of the female genital tract synchronously involving the vulva and uterine cervix

Medicine ◽

10.1097/md.0000000000016366 ◽

2019 ◽

Vol 98 (30) ◽

pp. e16366 ◽

Cited By ~ 2

Author(s):

Yingxin Pang ◽

Hang Yuan ◽

Anji Ren ◽

Shiqian Zhang ◽

Peishu Liu

Keyword(s):

Malignant Melanoma ◽

Uterine Cervix ◽

Genital Tract ◽

Female Genital Tract ◽

Primary Malignant Melanoma ◽

Female Genital

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Multidisciplinary Approach in the Management of Primary Malignant Melanoma of the Uterine Cervix: Diagnostic and Management Challenges

Journal of Gynecologic Surgery ◽

10.1089/gyn.2018.0005 ◽

2018 ◽

Vol 34 (4) ◽

pp. 209-213 ◽

Cited By ~ 1

Author(s):

Anastasios Tranoulis ◽

Alexandros Laios ◽

Sharika Munot ◽

George Theophilou ◽

Darshana Pathak ◽

...

Keyword(s):

Malignant Melanoma ◽

Uterine Cervix ◽

Multidisciplinary Approach ◽

Primary Malignant Melanoma

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Recurrent vaginal discharge: an unusual presentation of embryonal rhabdomyosarcoma of uterine cervix in an adolescent girl

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20191983 ◽

2019 ◽

Vol 8 (5) ◽

pp. 2129

Author(s):

Divya Sarin ◽

Urmila Singh ◽

Seema Mehrotra ◽

Vandana Solanki

Keyword(s):

Medical Treatment ◽

Uterine Cervix ◽

Adolescent Girl ◽

Vaginal Discharge ◽

Histopathological Examination ◽

Female Genital Tract ◽

Reproductive Function ◽

Embryonal Rhabdomyosarcoma ◽

Management Challenge

Embryonal rhabdomyosarcoma (ERMS) is a rare tumor of the female genital tract. It tends to occur during childhood in the vagina and rarely it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of 15 year old adolescent girl who presented with recurrent vaginal discharge not responding to medical treatment. Examination under anesthesia showed friable growth arising from the cervix. Histopathological examination revealed embryonal rhabdomyosarcoma (botyroid variant) of the cervix. Patient underwent local excision of growth followed by IRS-4 protocol based chemotherapy and now patient is under follow up at our side and pediatric oncology and doing well. Young girls presenting with recurrent vaginal discharge not responding to medical treatment must undergo proper clinical examination and EUA and any suspicious lesions should be examined so as to avoid missing rare but aggressive etiology like rhabdomyosarcoma. Due to the young age of affected patients, embryonal rhabdomyosarcoma (sarcoma botyroides) poses a management challenge as the preservation of hormonal, sexual and reproductive function is essential. Awareness of such as uncommon lesion and its clinical implications is important for the counseling and management of the patient.

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