Scriptures Fit for a King

This paper examines the use of translational doublets (multiple translations of a single expression presented together in a translated text) in the revised text of the Later Version of the Wycliffite Bible found in Oxford University MS. Bodley 277 (1420s or 1430s). The manuscript in question contains a large number of doublets found in no other copy of the Wycliffite Bible, and these appear to be the contributions of an independent revisor. The various functions that doublets have in this text are discussed, and it is argued that, in his use of doublets, the revisor focused primarily on clarifying or explaining details of the text’s literal, immediate meaning, especially in Old Testament historical books. It is suggested, moreover, that a large proportion of the revisor’s doublets reflect the interests of an aristocratic or royal audience, in line with the probable origin of MS. Bodley 277 (which was once owned by King Henry VI). Special attention is paid to the apocryphal 3 Ezra, for which Bodley 277 is the only copy of the Wycliffite Bible to include translational doublets and which appears in no other manuscript of the Later Version.

Women, War and Words: a Verbal Archaeology of Shield-maidens

Scholarly discussions of the question of the participation of women in war in the Viking Age have based their arguments on a variety of evidence, including both archaeology and texts. However, even those scholars who make substantial use of the textual evidence have not paid sufficiently close attention to (a) the vocabulary used in the representations (whether historical or fictional) of women acting in the supposed male role of warrior and (b) the literary-historical contexts in which the texts were produced, including potential relationships between texts. To further these discussions, this paper proposes a method which might be called the ‘stratigraphy of texts’ to demonstrate how a careful sifting of the cumulative textual evidence can enrich discussion about this important question. With close attention to the vocabulary used by the texts, and by considering the date, genre and sources of, and – importantly – the relationships between, texts in Old Norse, the discussion will demonstrate what can and what cannot be deduced from these textual representations of female warriors in the Viking Age. The paper will focus on tracing the development of the Old Norse concept of the skjaldmær, ‘shield-maiden’, through a variety of texts in which this term occurs, and also suggest a probable origin for the concept. There will also be a brief consideration of the term ‘valkyrie’ (ON valkyrja).

COVID-19 as a zoonotic infection

Here we discuss the issues for attributing the new coronavirus infection COVID-19 to zoonoses based on the data on probable origin of the SARS-CoV-2 virus, the possible formation of its reservoir in animals (bats) as well as human susceptibility. Today, the dominant point of view is that the outbreak of COVID-19 arose as a result of the SARS-CoV-2 coronavirus overcoming the interspecies barrier, acquiring ability to infect and spread in human population. Comparative phylogenetic analysis at the molecular level showed that SARS-CoV-2 is genetically closest to bat coronaviruses, particularly to the RmYN02 and RaTG13 strains isolated from the horseshoe bat, a species considered to be the main host of SARSCoV and MERS-CoV coronaviruses. The ability of the SARS-CoV-2 coronavirus to infect various wild animal has been revealed. SARS-CoV-2 has been found in minks on farms in the Netherlands with mortality rates ranging from 1.2 to 2.4%. While infecting rhesus monkeys with the SARS-CoV-2, it resulted in productive infection and detected viremia. Cats have been found to be susceptible hosts for the human SARS-CoV-2 virus. A likely explanation for this lies in the high similarity between the human and feline counterpart of the ACE2 receptor. It has been shown that dogs can become infected but transmit no virus to other animals. To date, over the entire period of the pandemic the World Organization for Animal Health provides no information about cases of human infection transmitted from pets. Thus, there is no evidence that animals play a role in the spread of SARS-CoV-2 among people during the current period of the pandemic. Human outbreaks are caused by human-to-human virus transmission, and based on the currently available information, the risk of spreading COVID-19 from animals is considered low. More research is needed to understand how COVID-19 can affect animals of a wide variety of species and how big might be the risks of infection transmission from them to humans.

Rectal perforation, a rare presentation of a swollen limb

Soft tissue infection of right lower limb secondary to perforation of the gastrointestinal tract is very rare and the true incidence is probably higher, as some cases will be misdiagnosed as gas gangrene unless careful clinical examinations are performed. Only rapid recognition of the probable origin of the gas, coupled with aggressive, definitive therapy, can prevent the usually fatal course of this condition. In the absence of trauma or infection in a previously normal leg, subcutaneous emphysema of a limb should alert the clinician to the possibility of a gastrointestinal perforation as a source of the gas. Perforations of the gastrointestinal tract into the subcutaneous tissue can occur anywhere from the neck to the lower extremities. The mechanisms and anatomical pathways are discussed in this case report. Diversion colostomy with incision and drainage of the lower limb of the same is a safe and feasible option.

First Coronavirus Active Survey in Rodents From the Canary Islands

Since the beginning of the 21st century five new coronaviruses inducing respiratory diseases in humans have been reported. These emergences has promoted research on coronaviruses in wildlife. We started the first eco-epidemiological study to screen the presence of coronaviruses circulating in mice and rats of four Canary Islands. Between 2015 and 2019, we obtained fecal samples of three rodent species (150 Mus musculus, 109 Rattus rattus and 1 Rattus norvegicus) captured in urban and rural areas. Fecal samples were analyzed by nRT-PCR and the resulting sequences were compared to known diversity using Bayesian phylogenetic methods. We only found coronavirus RNA in house mice from El Hierro (10.53%), Tenerife (7.02%) and Lanzarote (5.26%) islands. All coronaviruses detected belong to the species Murine coronavirus belonging to the genus Betacoronavirus and subgenus Embecovirus, being all positive house mice captured in anthropogenic environment. The phylogenetic analysis shows that murine coronaviruses from the Canary Islands are related to European murine coronaviruses. Albeit data are still scarce in the region, the most probable origin of M. coronavirus present in the Canary Islands is continental Europe. According to temporal Bayesian phylogenetics, the differentiation between Canary and continental viruses seems to be quite recent. Moreover, murine coronaviruses from El Hierro, Tenerife and Lanzarote islands tend to segregate in different clades. This enlightens the potential role of rodents or other possibly invasive species in disseminating infectious diseases to remote places through exchanges with the continent. It is important to consider these aspects in the sanitary control of islands, for health and biodiversity preservation concerns.

Durkheim’s totemic principle, shamanism and Southern African San religions

The study reappraised Emile Durkheim’s totemic principle in relation to the origins of religion and culture, using, amongst others, speech act theory and recent southern African epistemologies, especially David Lewis-Williams’ theory of shamanism, potency and altered states of consciousness. The study was text-based, qualitative and interpretive, and used key texts from anthropology, archaeology, history of religion, sociology and philosophy. It outlined Durkheim’s theory of the totemic principle and critiqued it, using performativity, cognitive neuroscience and southern African ethnography. Durkheim’s sociological reduction of God and religion to society and his dismissal of individual psychological experience were criticised. Lewis-Williams’ shamanism, both as a general theory and with particular reference to the San, was explored as an alternative to Durkheim’s totemism, animals playing a central but different function in each system. Although his understanding of performativity and sociopolitical relations in religion was inchoate, Durkheim helped demystify religion and establish social constructionism. He overestimated collective affect and sentiments and underestimated the role played by individual altered states of consciousness in the origin of religion.Contribution: The study critically evaluates Durkheim’s reduction of religion to society using current concepts of performativity, Matthias Guenther’s New Animism and David Lewis-Williams’ revised shamanism, particularly its ideas of trance dance, potency and altered states of consciousness, and posits shamanism rather than totemism as the probable origin of religion.

Epidemiology of COVID-19 in the State of Sergipe/Brazil and Its Relationship with Social Indicators

A pandemic is capable of generating a great impact, not only from the point of view of health, but also socioeconomically. In March 2020, the World Health Organization (WHO) declared that a new pandemic situation had arisen, due to the SARS-CoV-2 virus, whose probable origin was zoonotic. The largest number of cases of this disease is concentrated in the United States of America (USA), India, and Brazil. The mortality rate is estimated at 3.4%, but regional differences may exist, and places with a high demographic density have become true epicentres and may be related to higher rates of transmission. In addition to the above, lower human development indexes (HDI) can be related to worse outcomes, especially in the North and Northeast regions of Brazil since they are the least developed places. The Northeast region is the second-most-affected place in the number of COVID-19 cases in Brazil. An analytical observational study of an ecological type was carried out from April to October 2020 to assess the epidemiological situation of COVID-19 in the state of Sergipe and specifically to analyse the incidence of cases and deaths resulting from COVID-19 in the different health regions of the state of Sergipe, in relation to the values of the HDI and demographic density. During the study period, 84,325 cases of COVID-19 were identified, in which 2205 resulted in death. In most of the regions studied, there was a positive association between the number of cases and deaths and the greater the demographic density, but there was no increase in the risk of becoming ill, nor of dying the lower the HDI. Large and crowded cities are places of greatest vulnerability to illness, due to their greater capacity of transmitting the virus; however, further studies are needed to identify other factors that are decisive in the outcomes of this new disease.

The Dilemma of Falls in Older Persons: Never Forget to Investigate the Syncope

Background and objectives: Falls represent a major cause of morbidity, hospitalizations, and mortality in older persons. The identification of risk conditions for falling is crucial. This study investigated the presence of syncope as a possible cause of falls in older persons admitted to a Sub-Acute Care Unit (SACU) with a diagnosis of accidental fall after initial management in an emergency department and acute hospitalization. Materials and methods: A retrospective monocentric study of patients aged ≥65 years, consecutively admitted to a SACU with a diagnosis of fall-related trauma. All patients underwent a complete assessment of the index event and clinical status. Patients were categorized into three groups according to the identified cause of falls: (1) transient loss of consciousness (T-LOC), (2) unexplained fall (UF), and (3) definite accidental fall (AF). Results: A total of 100 patients were evaluated. T-LOC was present in 36 patients, UF in 37, and AF in 27. Of the 36 patients with T-LOC, a probable origin was identified in most cases (n = 33, 91%), 19 subjects (53%) had orthostatic hypotension, 9 (25%) a cardiac relevant disturbance, 2 (6%) a reproduced vaso-vagal syncope, 2 (6%) severe anemia, and 1 (3%) severe hypothyroidism. The T-LOC group was older and more clinically complex than the other groups. Conclusion: In older patients who recently experienced a fall event, the prevalence of syncope is relevant. In frail and clinically complex patients with falls, the identification of the underlying cause is pivotal and can be achieved through prolonged monitoring and a comprehensive assessment of the person.

The Bayesian reconstruction and the evolutionary history of Salivirus type 1 and type 2: the worldwide spreading

Introduction: Salivirus (SalV) represents an emerging problem in public health especially during the recent years. In this study, the Bayesian evolutionary history and the spread of the virus through the different countries have been reported. Methodology: a database of 81 sequences of SalV structural VP1 fragment were downloaded from GenBank, aligned and manually edited by Bioedit Software. ModelTest v. 3.7 software was used to estimate the simplest evolutionary model fitting the sequence dataset. A Maximum-Likelihood tree has been generated using MEGA-X to test the “clockliness” signal using TempEst 1.5.1. The Bayesian phylogenetic tree was built by BEAST. Homology modelling was performed by SWISS-Model and protein variability evaluated by ConSurf server. Results: the phylogenetic tree showed a clade of SalV A2 and three main clades of SalV A1, revealing several infections in humans in South Korea, India, Tunisia, China, Nigeria, Ethiopia and USA. The Bayesian maximum clade credibility tree and the time of the most common recent ancestor dated back the root of the tree to the year 1788 with the probable origin in USA. Selective pressure analysis revealed two positive selection sites, His at 100th and Leu at 116th positions that at the homology modelling resulted important to guarantee protein stability and variability. This could contribute to the development of new mutations modifying the clinical features of this evolving virus. Conclusions: Bayesian phylogenetic and phylodynamic represented a useful tool to follow the transmission dynamic of SalV and to prevent new epidemics worldwide.

Soto J & al_2021_SARS-CoV-2_ECCC

Background: Following an outbreak in April 2020 in Quebec, Canada, an investigation was carried out to characterize SARS-CoV-2 transmission within an Emergency Childcare Centre (ECCC) setting.Methods: The study population consisted of all the children and employees who attended the ECCC as well as household contacts of the confirmed COVID-19 cases. Of the 120 individuals in the study, five cases were confirmed by epidemiological link and 25 were identified as COVID-19 by RT-PCR among which 19 were analysed by viral whole genome sequencing. Descriptive epidemiology, social network visualization, and phylogenetic analysis were used. The study period was April 9 to May 18, 2020.Findings: Phylogenetic analysis identified two separate introductions of distinct lineages of SARS-CoV-2 and estimated an average reproductive value of R = 1.9 (range 0.9 - 4.9) with a mean doubling time of 3.2 days (range 2.1 - 5.2). The first and most prevalent lineage was introduced by two asymptomatic children who were likely infected by their parent, a confirmed COVID-19 case working in a long-term care centre. Among infected household adults, attack rates were significantly higher in mothers than fathers (risk ratio = 4.5; 95% CI= 1.1-18.7). The extent of transmission makes it one of the largest documented outbreaks in a daycare in Canada.Interpretation: The analyses carried out showed the probable origin and direction of the transmission of the infection (adult-child, child-adult, and child-child), thus highlighting how asymptomatic children can efficiently transmit SARS-CoV-2.