Abstract
Objective
To investigate the influencing factors of venous thromboembolism (VTE) after ovarian cancer surgery, and construct its prediction model.
Methods
A total of 67 patients with ovarian cancer who developed VTE after surgery were selected from October 2008 to June 2020 in the Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, and conducted a retrospective study with 100 patients without VTE after the operation who were confirmed by imaging during the same period. The clinical data of two groups of patients were analyzed and compared, and the risk prediction model was established. The ROC curve was drawn to evaluate the prediction effect of the model.
Results
Univariate analysis showed that there were statistically significant differences in age, menopausal status, hypertension, neoadjuvant chemotherapy, FIGO staging, lymph node metastasis, operation time, preoperative plasma FIB and D-dimer between the thrombosis group and the non-thrombosis group;The results of multivariate analysis showed that old age, neoadjuvant chemotherapy, late FIGO staging, high levels of plasma FIB and D-dimer before surgery are independent risk factors for VTE after ovarian cancer surgery. Construct a prediction model based on the results of multivariate regression analysis: Logit(P) = 0.053 × age + 0.917 × neoadjuvant chemotherapy + 0.956 × tumor FIGO staging + 0.398 × preoperative plasma FIB + 0.531 × preoperative D-dimer -7.679 ( Neoadjuvant chemotherapy, yes=1, no=0; tumor FIGO stage Ⅰ+Ⅱ=1, Ⅲ+Ⅳ=2; age, preoperative plasma FIB and D-dimer are actual values). The ROC curve analysis shows that the AUC value of the model is 0.773, the sensitivity is 74.6%, the specificity is 71.0%, and the total prediction accuracy rate is (78+39)/167=0.701.
Conclusions
Age, neoadjuvant chemotherapy, tumor FIGO staging, preoperative plasma FIB and D-dimer can be used as reliable indicators to predict the occurrence of postoperative VTE in patients with ovarian cancer. The constructed prediction model has good risk prediction ability, It has certain clinical application value.