scholarly journals Evaluation of depression in the patients with congestive heart disease

2013 ◽  
Vol 50 (6) ◽  
pp. 748-751
Author(s):  
Hiroyuki Yokoyama
Keyword(s):  
Heart Disease ◽  
Congestive Heart Disease

scholarly journals AB0308 NO SIGNS OF CONGESTIVE HEART DISEASE PROGRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS ON IL-6 RECEPTOR ANTAGONIST AFTER 12 MONTHS TREATMENT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1452.3-1453
Author(s):  
A. Martynova ◽  
T. Popkova ◽  
H. Gerasimova
Keyword(s):  
Rheumatoid Arthritis ◽  
Heart Disease ◽  
Receptor Antagonist ◽  
Disease Progression ◽  
European Heart Journal ◽  
Heart Function ◽  
Clinical Signs ◽  
Left Ventricular ◽  
Ultrasound Evaluation ◽  
Congestive Heart Disease

Background:N-terminal pro-brain natriuretic peptide (NT-proBNP) is a known marker of heart dysfunction, mainly described in patients with high activity of rheumatoid arthritis (RA). Further knowledge of the influence of the IL-6 receptor antagonist, tocilizumab (TCZ), on NT-proBNP levels and systolic heart function is yet to be obtained.Objectives:Access the effect of 12 months TCZ therapy on NT-proBNP levels, transthoracal ehocardiography results and analyze the association between congestive heart disease progression and RA activity.Methods:37 RA patients (pts) (31F/6M); median age 56,5 [48; 63,5] years; disease duration 48 [6; 348] months; DAS28 score 6,15 [5,44; 6,45]; rheumatoid factor (RF)+100%; anti–citrullinated protein antibody (ACPA) + 79,6% were treated in an open-label study with TCZ (8 mg/kg every 4 weeks). Identification of NT-pro-BNT in blood serum, transthoracal ultrasound evaluation of left ventriculum ejection fraction (LVEF), E/A ratio performed at baseline and 12 months.Results:11 (29,7%) pts had congestive heart disease (CHD) (II functional class of NYHA), 7 (18,9%) pts having signs of mild left ventricular dysfunction (LVD) as dyspnea, shortness of breath, cardiotropic treatment remained the same in the course of the study. After 12 month TCZ treatment as RA activity lowered (DAS28 2.32 [1,75; 3,15], р<0,05), NT-proBNP levels decreased (100,95 [57.9; 117.6] pg/ml to 90,46 [33.62; 106.6] pg/ml), along with elevation of LVEF (60,75 [60; 70]% to 67,68 [62.5; 73.5], p = 0,001). Increase of E/A (0,97 [0.8; 1.17] to 1,04 [0.7; 1.42] correlated with decrease of NT-proBNP level (r = -0,63, p=0,036). Raise of LVEF over 12 months correlated with decrease of RA activity according to SDAI scale (r= -0,670, p<0,05). No significant relationship between NT-proBNP levels, LVEF, E/A and other scales measuring RA activity was found. Clinically all patients had improvement in evaluation of their health and no signs of CHD or RVD progression were found.Conclusion:Use of TCZ in patients with active RA showed none to positive influence on heart condition, specifically, lowering NT-proBNP levels, improving LVEF and reducing clinical signs of LVD.References:[1]Pan Y, Li D, Ma J, Shan L, Wei M. NT-proBNP test with improved accuracy for the diagnosis of chronic heart failure. Medicine (Baltimore). 2017 Dec;96(51):e9181.[2]D Novikova, I Kirillova, E Markelova et al. The first report of significantly improvement of NT-proBNP level in rheumatoid arthritis patients treated with tofacitinib during 12-month follow-up, European Heart Journal, Volume 40, Issue Supplement_1, October 2019, ehz745.0836.[3]Pappas DA, Nyberg F, Kremer JM et al. Clin Rheumatol. 2018 Sep;37(9):2331-2340.Disclosure of Interests:None declared

Independent Prognostic Value of Right Atrial Pressure in Patients with Congestive Heart Disease

2013 ◽  
Vol 19 (10) ◽  
pp. S145
Author(s):  
Yoshiharu Sada ◽  
Hiroki Kinoshita ◽  
Tomohiko Kisaka ◽  
Yoshihiro Dohi ◽  
Yasuki Kihara
Keyword(s):  
Heart Disease ◽  
Prognostic Value ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Congestive Heart Disease

Digitalis for congestive heart disease in the elderly

1987 ◽  
Vol 81 (2) ◽  
pp. 141-152 ◽  
Author(s):  
James G. Jones ◽  
Harold Kallman ◽  
Dennis A. Revicki
Keyword(s):  
Heart Disease ◽  
The Elderly ◽  
Congestive Heart Disease

The Case of Dr. Kevorkian and Mr. Gale: A Brief Historical Note

1997 ◽  
Vol 36 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Kalman J. Kaplan
Keyword(s):  
Carbon Monoxide ◽  
Heart Disease ◽  
Historical Note ◽  
Congestive Heart Disease ◽  
Gas Mask ◽  
Search Warrant

One of Jack Kevorkian's most controversial cases involved Hugh Gale, a seventy-year-old man suffering from emphysema and congestive heart disease, who was found dead on February 15, 1993 with a canister of carbon monoxide attached to a gas mask on his face. A document discovered in a garbage bag indicated that Gale had attempted to change his mind prior to his death requesting that the mask be taken off two separate times. The document revealed mat Kevorkian removed the mask only once, the patient lapsing into unconsciousness after the second request—and dying. A search warrant of Kevorkian's apartment was issued as a result of this discovery, revealing a copy of the original document which had been altered to conceal the second request by Gale to remove the mask. The prosecutor decided against bringing charges against Kevorkian because of the lack of corroboration among the witnesses present at Mr. Gale's death.

scholarly journals Streptococcus canis Bacteremia in a Renal Transplant Recipient

2019 ◽  
Vol 7 ◽  
pp. 232470961983459 ◽  
Author(s):  
Syed M. H. Zaidi ◽  
Ambika Eranki
Keyword(s):  
Heart Disease ◽  
Renal Transplant ◽  
Deceased Donor ◽  
Blood Cultures ◽  
Shortness Of Breath ◽  
First Case ◽  
Congestive Heart Disease ◽  
History Of ◽  
Streptococcus Canis ◽  
Initial Blood

A middle-aged man presented with fever and shortness of breath. He had significant history of congestive heart disease and received deceased donor renal transplant 2 years prior to presentation. He was febrile and found to have sepsis. His initial blood cultures grew Streptococcus canis. Streptococcus canis causes rare infection in humans, and this is most likely the first case in the renal transplant population.

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