A rare benign lesion in the lung: Clear Cell “Sugar” tumor (CCST)

The primary clear cell tumor of the lung is an extremely rare benign tumor, which is called “sugar tumor”, because of the large content of glycogen. Here we are presenting essential thrombocythemia and lung clear cell tumor which was not reported before to the best of our knowledge.A 44 years old woman admitted to the clinic with complaint of lassitude lasting for 2 months. In her physical examination the spleen was 3 cm palpable from the costa arch In laboratory findings number of platelet was 1014000 mm³. A 3.5 cm in diameter pulmonary nodule is detected in right upper lobe in the graphy of the lungs. Subsequently computed tomography (CT ) of thorax was carried out. Due to the benign features in the display of the detected nodule, a total excision with curative and diagnostic intentions was performed. Microscopically the tumor were composed of nests of rounded or oval cells with distinct cell borders and optically clear cytoplasm. The nuclei were small. Immunohistochemically the tumor cells expressed HMB-45, NSE and focal S100 antigen. It was diagnosed as clear “sugar” cell tumor. In conclusion, in lung clear cell tumor, it is important to make evaluation in terms of myeloproliferative disease in adults whose thrombocytosis continue after the treatment.

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Clear Cell Sugar Tumor

Soft Tissue Tumors ◽

10.1007/978-3-030-58710-9_53 ◽

2020 ◽

pp. 177-178

Author(s):

Simone Mocellin

Keyword(s):

Clear Cell ◽

Sugar Tumor

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Cathepsin K expression in clear cell “sugar” tumor (PEComa) of the lung

Virchows Archiv ◽

10.1007/s00428-018-2325-1 ◽

2018 ◽

Vol 473 (1) ◽

pp. 55-59 ◽

Cited By ~ 2

Author(s):

Anna Caliò ◽

Maria Cecilia Mengoli ◽

Alberto Cavazza ◽

Giulio Rossi ◽

Claudio Ghimenton ◽

...

Keyword(s):

Clear Cell ◽

Cathepsin K ◽

Sugar Tumor

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Clear cell (“sugar”) tumor of the lung is a lesion strictly related to angiomyolipoma— The concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC)

Pathology ◽

10.1080/00313029400169561 ◽

1994 ◽

Vol 26 (3) ◽

pp. 230-236 ◽

Cited By ~ 205

Author(s):

F. Bonetti ◽

M. Pea ◽

G. Martignoni ◽

G. Zamboni ◽

P. Capelli ◽

...

Keyword(s):

Clear Cell ◽

Epithelioid Cells ◽

Sugar Tumor

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An Inguinal Perivascular Epithelioid Cell Tumor Metastatic to the Orbit

Case Reports in Pathology ◽

10.1155/2018/5749421 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Zofia Tynski ◽

Way Chiang ◽

Albert Barrett

Keyword(s):

Clear Cell ◽

Middle Age ◽

Epithelioid Cell ◽

Ligamentum Teres ◽

Cell Tumor ◽

The Third ◽

Perivascular Epithelioid Cell ◽

Mesenchymal Neoplasms ◽

First Case ◽

Sugar Tumor

Malignant PEComas are rare mesenchymal neoplasms. These tumors harbor distinct myomelanocytic phenotype. The PEComa family of tumors includes lymphangioleiomyomatosis, angiomyolipoma, clear cell sugar tumor of the lung, and myomelanocytic tumor of the falciparum ligament/ligamentum teres. PEComas have no known normal cell counterpart. Majority of PEComas are benign and occur predominantly in the middle-age women. These tumors are commonly encountered in the uterus. Herein, we report a 20-year-old woman with a left inguinal mass metastatic to orbit, brain, lumbar spine, and skin at presentation. To our knowledge, this is the first case of metastatic PEComa to the orbit. This is the third case of primary PEComa of the inguinal area.

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Metastasis to the scalp as the first finding of Clear Cell Carcinoma of the Kidney: Case Report and Review of the Literature

International Journal of Cancer Research & Therapy ◽

10.33140/ijcrt.05.01.04 ◽

2020 ◽

Vol 5 (1) ◽

Keyword(s):

Skin Lesion ◽

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Benign Lesion ◽

Traumatic Injury ◽

Pulmonary Nodules ◽

Review Of The Literature ◽

Post Traumatic ◽

Renal Origin

The case of a 70-year-old man, with no previous pathological history, who consulted for post-traumatic injury to the scalp; it was managed as a benign lesion and it was taken to surgical resection with a histopathology and immunohistochemistry study compatible with clear cell neoplasia of metastatic renal origin. Extension studies were performed with findings of pulmonary nodules that suggested metastatic disease and with a finding of right renal mass. Radical nephrectomy is performed confirming the diagnosis of renal cell carcinoma subtype clear cells. A review of the literature was carried out, which shows that a skin lesion may be the first symptom of an internal neoplasm, with breast cancer being the most frequent one reported in the literature in cutaneous metastases. The finding of a posttraumatic injury to the scalp as the first sign of a clear cell carcinoma of renal origin is very rare. The diagnosis of skin metastases requires a histopathology and immunohistochemistry study, which must be timely because it may be the first link in the research chain to detect an occult neoplasm. In conclusion, the surgeon who faces a soft tissue tumor on the scalp must consider the characteristics of the lesion, the patient’s risk factors in an articulated way that allows him to suspect malignancy in a skin lesion and that allows him diagnose a previously unknown and asymptomatic neoplasm.

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