Orphan designation: Doxorubicin hydrochloride (in heat-sensitive liposomes), Treatment of hepatocellular carcinoma

2019 ◽  
Author(s):  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Doxorubicin Hydrochloride ◽  
Orphan Designation

scholarly journals Retinoic Acid Decorated Albumin-Chitosan Nanoparticles for Targeted Delivery of Doxorubicin Hydrochloride in Hepatocellular Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Hojjat Sadeghi ◽  
Zahra Ghelich Khan ◽  
Mahboobeh Rostami
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retinoic Acid ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
Free Drug ◽  
Potential Drug ◽  
Doxorubicin Hydrochloride ◽  
Albumin Nanoparticles ◽  
Successful Production

Retinoic acid (R) grafted chitosan (C) copolymers with different degree of substitution of retinoic acid on the chitosan were synthesized. Retinoic acid targeted chitosan-albumin nanoparticles were prepared for targeted delivery of doxorubicin in hepatocellular carcinoma by coacervation method. Physical properties of nanoparticles including particle size, zeta potential, drug loading efficiency, and drug release profiles were studied. TEM micrographs were taken to see the morphology of nanoparticles. The cytotoxicity of doxorubicin-loaded nanoparticles was studied on HepG2 cells using MTT assay and their cellular uptake by fluorescence microscopy. FTIR and1HNMR spectra confirmed successful production of RC conjugate which was used in production of the targeted RC-albumin nanoparticles. IC50of drug loaded in these nanoparticles reduced to half and one-third compared to nontargeted nanoparticles and free drug, respectively.

Lipiodol-CT in the Detection of Tumor Persistence in Hepatocellular Carcinoma Treated with Percutaneous Ethanol Injection

1994 ◽  
Vol 35 (4) ◽  
pp. 323-328 ◽  
Author(s):  
R. Lencioni ◽  
D. Caramella ◽  
C. Vignali ◽  
R. Russo ◽  
A. Paolicchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
False Negative ◽  
Percutaneous Ethanol Injection ◽  
Diagnostic Value ◽  
Doxorubicin Hydrochloride ◽  
Iodized Oil ◽  
Neoplastic Tissue ◽  
Ethanol Injection ◽  
Tumor Persistence ◽  
Positive Results

Our purpose was to investigate the usefulness of Lipiodol-CT for detection of residual viable neoplastic tissue in hepatocellular carcinoma (HCC) lesions treated by means of percutaneous ethanol injection (PEI). An emulsion of 5 to 20 ml iodized oil and 50 to 70 mg doxorubicin hydrochloride was intraarterially injected in 18 patients with 25 HCC lesions treated by means of PEI one to 24 months before. At CT performed 3 to 5 weeks after injection, retention of Lipiodol was observed in 9 of 13 tumors that still contained viable neoplastic tissue and in 2 of 12 tumors proven to have undergone complete necrosis after PEI. The sensitivity and specificity of Lipiodol-CT were 69.2% and 83.3%, respectively. Thus, Lipiodol-CT seems to have limited diagnostic value after PEI, probably as a consequence of the alcohol-induced vascular damage, accounting for both false-negative and false-positive results.

scholarly journals Surface functionalization of superparamagnetic nanoparticles by an acid-liable polysaccharide-based prodrug for combinatorial monitoring and chemotherapy of hepatocellular carcinoma

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41919-41928 ◽  
Author(s):  
Chaoping Fu ◽  
Rui-Meng Yang ◽  
Li Wang ◽  
Nan-nan Li ◽  
Meng Qi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Surface Functionalization ◽  
Superparamagnetic Nanoparticles ◽  
Liver Carcinoma ◽  
Oxide Nanoparticles ◽  
Doxorubicin Hydrochloride ◽  
Macromolecular Prodrug ◽  
Acid Labile

For combinatorial monitoring and chemotherapy of liver carcinoma, the macromolecular prodrug based on hyaluronic acid and doxorubicin hydrochloride was prepared by an acid-labile linkage and conjugated with amine-modified iron oxide nanoparticles.

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