Clinicopathological study of 53 tumors of the pineal region

1973 ◽  
Vol 39 (4) ◽  
pp. 455-462 ◽  
Author(s):  
Umberto DeGirolami ◽  
Henry Schmidek
Keyword(s):  
General Hospital ◽  
Massachusetts General Hospital ◽  
Pineal Region ◽  
Pathological Features ◽  
Content Type ◽  
Clinicopathological Study ◽  
Ventricular Tumors ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ Fifty-three cases of pineal and posterior-third ventricular tumors seen at the Massachusetts General Hospital from 1920 to 1972 are reviewed. This series includes 35 pathologically verified tumors and 18 cases accepted as pineal neoplasms on clinical and radiographic grounds. A plan of management is proposed based on a correlation between the clinical and pathological features and the response of each type of tumor to the currently available modes of therapy.

Giant gangliocytic paraganglioma of the filum terminale

1990 ◽  
Vol 73 (3) ◽  
pp. 459-461 ◽  
Author(s):  
Michel Djindjian ◽  
Patrick Ayache ◽  
Pierre Brugières ◽  
Denis Malapert ◽  
Marielle Baudrimont ◽  
...  
Keyword(s):  
Cauda Equina ◽  
Filum Terminale ◽  
Pathological Features ◽  
Gangliocytic Paraganglioma ◽  
Content Type ◽  
Considerable Similarity ◽  
Large Neurons ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ The clinical and pathological features of a giant cauda equina paraganglioma arising from the intradural filum terminale is described. Scattered mature large neurons characterized the tumor as a gangliocytic paraganglioma. Histologically, these neoplasms have considerable similarity with ependymoma and the diagnosis can be easily missed unless special techniques are employed.

Clinical and pathological study of 24 cases of gliosarcoma

1976 ◽  
Vol 45 (4) ◽  
pp. 398-408 ◽  
Author(s):  
Robert A. Morantz ◽  
Irwin Feigin ◽  
Joseph Ransohoff
Keyword(s):  
Glioblastoma Multiforme ◽  
Temporal Lobe ◽  
Pathological Features ◽  
Pathological Study ◽  
Content Type ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ The authors review the clinical and pathological features of 24 patients with gliosarcoma. The study revealed the following findings. Gliosarcoma occurs more frequently than is indicated in the literature, and in our series was present in 8% of all cases of glioblastoma multiforme. The presenting features are not significantly different from those of glioblastoma multiforme. The lesion often presents itself at surgery as a firm, well circumscribed mass within the temporal lobe, and at surgery it is commonly mistaken for a meningioma. There is an increased likelihood of metastasis compared to that of glioblastoma. The prognosis is no worse than that of glioblastoma, in spite of the addition of sarcomatous elements.

The Massachusetts General Hospital

1993 ◽  
Vol 79 (6) ◽  
pp. 948-958 ◽  
Author(s):  
Fred G. Barker
Keyword(s):  
Medical Student ◽  
General Hospital ◽  
Massachusetts General Hospital ◽  
Early History ◽  
Brain Surgery ◽  
Content Type ◽  
Harvey Cushing ◽  
History Of ◽  
Neurological Surgery ◽  
Fine Print

✓ The early history of the Massachusetts General Hospital (MGH) is reviewed with emphasis on the development of neurological surgery. The hospital opened in 1823. Early trephinations were performed by Dr. John Collins Warren and others for treatment of trauma and epilepsy. In the 1880's, interest in brain surgery increased, and Dr. John Elliot performed several trephinations for brain tumors, three of which were witnessed by Dr. Harvey Cushing during his years at the MGH as medical student and intern. In 1911, all brain surgery was placed in the hands of Dr. S. J. Mixter. He later shared the assignment with his son, Dr. W. J. Mixter, who described herniation of the intervertebral disc with Dr. J. S. Barr and became the first Chief of the Neurosurgical Service at MGH in 1939.

Intracranial sparganosis: an uncommon infection

1984 ◽  
Vol 60 (6) ◽  
pp. 1282-1286 ◽  
Author(s):  
Karl Anders ◽  
Kevin Foley ◽  
W. Eugene Stern ◽  
W. Jann Brown
Keyword(s):  
United States ◽  
Lower Extremity ◽  
Parietal Lobe ◽  
The United States ◽  
Pathological Features ◽  
Content Type ◽  
First Case ◽  
The Right ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ The first case of intracranial sparganosis to be reported from the United States is presented. The patient, a 27-year-old woman, complained of focal seizures involving the right lower extremity. A left parietal parasagittal craniotomy was performed, and a granuloma containing a sparganum was excised from the parietal lobe. The clinical and pathological features of sparganosis are reviewed. Only five cases of intracranial sparganosis have previously been described.

Supratentorial intra-arachnoid cyst

1971 ◽  
Vol 35 (4) ◽  
pp. 477-482 ◽  
Author(s):  
Nitya R. Ghatak ◽  
Grace J. Mushrush
Keyword(s):  
Brain Stem ◽  
Arachnoid Cyst ◽  
Cerebral Hemisphere ◽  
Arachnoid Cysts ◽  
Neurological Deficits ◽  
Pathological Features ◽  
Content Type ◽  
The Brain ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ The clinical and pathological features of a primary supratentorial arachnoid cyst are described. Expansion of the cyst led to progressive neurological deficits that terminated fatally. There was severe compression and marked distortion of the brain with secondary brain stem hemorrhage. It is suggested that intra-arachnoid cysts may represent a distinct pathological entity among the heterogeneous cysts overlying the cerebral hemisphere.

Meningeal melanocytoma

1987 ◽  
Vol 66 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Ken R. Winston ◽  
Ana Sotrel ◽  
Stuart J. Schnitt
Keyword(s):  
Radiation Therapy ◽  
Trigeminal Nerve ◽  
Pathological Features ◽  
Content Type ◽  
Meningeal Melanocytoma ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ A melanin-producing, encapsulated, histologically benign-appearing tumor of the trigeminal nerve was surgically removed from a 9-year-old boy. It recurred 6 months later and was then subtotally resected and treated with radiation therapy. The clinical and pathological features of this and 10 similar cases reported in the literature are reviewed. These tumors are best categorized as meningeal melanocytomas.

Malignant intraventricular schwannoma

1995 ◽  
Vol 82 (1) ◽  
pp. 121-124 ◽  
Author(s):  
Jin-Myung Jung ◽  
Hyung-Jin Shin ◽  
Je G. Chi ◽  
In Sung Park ◽  
Eun Sang Kim ◽  
...  
Keyword(s):  
Lateral Ventricle ◽  
Malignant Schwannoma ◽  
Pathological Features ◽  
Content Type ◽  
The Right ◽  
Subtotal Removal ◽  
Fine Print

✓ The authors present the clinical, radiological, and pathological features of a malignant schwannoma occurring in the right lateral ventricle of a 40-year-old man. Metastasis to both cerebellopontine angles and to the cerebellum was found 7 months after subtotal removal of the tumor.

Malignant intracerebral nerve sheath tumor with intratumoral calcification

2000 ◽  
Vol 92 (2) ◽  
pp. 338-341 ◽  
Author(s):  
Minoru Tanaka ◽  
Soichiro Shibui ◽  
Kazuhiro Nomura ◽  
Yukihiro Nakanishi ◽  
Tadashi Hasegawa ◽  
...  
Keyword(s):  
Nerve Sheath Tumor ◽  
Pathological Features ◽  
Resonance Imaging ◽  
Content Type ◽  
Nerve Sheath ◽  
First Case ◽  
The Right ◽  
Tomography Scanning ◽  
Considerable Enhancement ◽  
Fine Print

✓ The authors present the clinical, radiological, and pathological features of a malignant intracerebral nerve sheath tumor that occurred in the right parietooccipital lobe of a 4-year-old girl. Computerized tomography scanning and magnetic resonance imaging demonstrated a 5 × 5 × 4—cm multiloculated mass with considerable enhancement of the irregularly shaped septa and clearly calcified areas within the mass. Among five cases reported in the literature, this patient is the youngest and represents the first case in which there is radiological evidence of intratumoral calcification.

Diagnosis and management of pineal tumors

1983 ◽  
Vol 58 (5) ◽  
pp. 654-665 ◽  
Author(s):  
Rashid Jooma ◽  
Brian E. Kendall
Keyword(s):  
Tumor Markers ◽  
Germ Cell Tumors ◽  
Ct Scanning ◽  
Individual Case ◽  
Pineal Region ◽  
Pineal Tumors ◽  
Content Type ◽  
Pineal Region Tumors ◽  
Primary Surgery ◽  
Fine Print

✓ The management of pineal region tumors remains controversial. Advocates of a conservative approach emphasize the excellent results of radiotherapy, particularly with germinomas, while a number of recent reports have demonstrated the safety of direct surgery. In order to improve treatment planning, attempts have been made to distinguish the various tumor types by computerized tomography (CT) and by the use of markers for germ-cell tumors. This paper reports a study of 35 patients with pineal tumors including two ectopic germinomas. Pretreatment CT was performed in all 35 patients, and human chorionic gonadotropin and alpha-fetoprotein levels were assayed in 11. Histological verification was available for 33 tumors; the other two were characterized by clinical and CT features plus tumor markers. Of the 27 tumor operations, 21 were for a pineal mass and six for ectopic germinoma or metastasis. There was no operative mortality. Morbidity was minimal, and surgery did not increase the incidence of subarachnoid seeding. Each histological type of tumor has a typical appearance on CT scanning, although, in the individual case, a firm diagnosis is not always possible. However, consideration of CT scans together with the clinical features, cerebrospinal fluid cytology, tumor markers, and (if there is still doubt) response to a small dose of irradiation will generally allow a specific diagnosis with a high degree of probability. In this way, germinomas may be selected for radiotherapy and the tumors less likely to respond may be subjected to primary surgery.

Stereotactic interstitial radiosurgery for cerebral metastases

2005 ◽  
Vol 103 (4) ◽  
pp. 630-635 ◽  
Author(s):  
William T. Curry ◽  
Garth Rees Cosgrove ◽  
Fred H. Hochberg ◽  
Jay Loeffler ◽  
Nicholas T. Zervas
Keyword(s):  
Brain Metastases ◽  
Local Control ◽  
Stereotactic Biopsy ◽  
Massachusetts General Hospital ◽  
Cerebral Metastases ◽  
Peripheral Dose ◽  
Primary Tumors ◽  
Content Type ◽  
Interstitial Radiosurgery ◽  
Fine Print

Object. The Photon Radiosurgery System (PRS) is a miniature x-ray generator that can stereotactically irradiate intracranial tumors by using low-energy photons. Treatment with the PRS typically occurs in conjunction with stereotactic biopsy, thereby providing diagnosis and treatment in one procedure. The authors review the treatment of patients with brain metastases with the aid of the PRS and discuss the indications, advantages, and limitations of this technique. Methods. Clinical characteristics, treatment parameters, neuroimaging-confirmed outcome, and survival were reviewed in all patients with histologically verified brain metastases who were treated with the PRS at the Massachusetts General Hospital between December 1992 and November 2000. Local control of lesions was defined as either stabilization or diminution in the size of the treated tumor as confirmed by Gd-enhanced magnetic resonance imaging. Between December 1992 and November 2000, 72 intracranial metastatic lesions in 60 patients were treated with the PRS. Primary tumors included lung (33 patients), melanoma (15 patients), renal cell (five patients), breast (two patients), esophageal (two patients), colon (one patient), and Merkle cell (one patient) cancers, and malignant fibrous histiocytoma (one patient). Supratentorial metastases were distributed throughout the cerebrum, with only one cerebellar metastasis. The lesions ranged in diameter from 6 to 40 mm and were treated with a minimal peripheral dose of 16 Gy (range 10–20 Gy). At the last follow-up examination (median 6 months), local disease control had been achieved in 48 (81%) of 59 tumors. An actuarial analysis demonstrated that the survival rates at 6 and 12 months were 63 and 34%, respectively. Patients with a single brain metastasis survived a mean of 11 months. Complications included four patients with postoperative seizures, three with symptomatic cerebral edema, two with hemorrhagic events, and three with symptomatic radiation necrosis requiring surgery. Conclusions. Stereotactic interstitial radiosurgery performed using the PRS can obtain local control of cerebral metastases at rates that are comparable to those achieved through open resection and external stereotactic radiosurgery. The major advantage of using the PRS is that effective treatment can be accomplished at the time of stereotactic biopsy.

Sign in / Sign up

Export Citation Format

Share Document