Compartmental analysis of regional cerebral blood flow in patients with acute severe head injuries

1977 ◽  
Vol 47 (5) ◽  
pp. 699-712 ◽  
Author(s):  
Erna M. Enevoldsen ◽  
Finn Taagehøj Jensen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Tissue ◽  
Regional Cerebral Blood Flow ◽  
Head Injuries ◽  
Initial Slope ◽  
Flow Index ◽  
Normal Brain ◽  
Regional Cerebral Blood ◽  
The Brain

✓ Bicompartmental analysis for the calculation of regional cerebral blood flow (rCBF) from 133Xe clearance in brain tissue has not been thoroughly explored in clinical studies. Most authors rely either on the average rCBF obtained by height/area analysis of the clearance curves or on the initial-slope flow index. Possibly the reason is that the validity of the bimodal flow distribution in abnormal brain tissue is considered questionable. In the present study, bicompartmental analysis, performed by a least-square computerized iterative approach, was used in the calculation of the flow and weight of the tissue of the brain of patients with severe head injuries. The analysis was found to give important information of the nature and course of the brain lesions even if the clearance curves did not have the normal bi-exponential shape, provided the results obtained were properly interpreted. In such cases, the values of the flow and relative weight could not be taken as flow and weight values of gray and white matter, but rather as indices of fast and slower flow components. The interpretation of the results was based on the identification of three types of 13-minute clearance curves, each being characteristic of a type of brain lesion. The clearance curves from fairly normal brain tissue appeared to be bi-exponential; curves from areas of severe cortical contusion had, in addition, an initial and rapid “third” component, a tissue peak, whereas curves from severely edematous brain tissue approached the monoexponential shape.

Reproducibility of regional cerebral blood flow measurements in acute severe head injury

1978 ◽  
Vol 49 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Erna M. Enevoldsen ◽  
Finn T. Jensen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Head Injuries ◽  
Initial Slope ◽  
Regional Cerebral Blood ◽  
Flow Measurements ◽  
Content Type ◽  
Flow Parameters ◽  
The Brain

✓ In order to evaluate the reproducibility of regional cerebral blood flow (rCBF) measurements in pathological brain tissue, serial measurements were carried out in 13 determinations performed in patients who were comatose after severe head injuries within the first 2 weeks after the head trauma. The xenon-133 intra-arterial method was used for the flow measurements, and the flow was studied separately in 16 areas of the brain, producing 197 regional double determinations. The patients were maintained in a steady state during and between the measurements, and only differences of less than 2 mm Hg in the arterial CO2 pressure and less than 5 mm Hg in the perfusion pressure were tolerated. The reproducibility was found to be reasonably good as regards initial slope-flow indices and height/area flow values, whereas that of the compartmentally calculated flow parameters was poorer. On dividing the series into severely and moderately pathological areas, it could be shown that the reproducibility of the flow values in the moderately pathological brain areas was acceptable and similar to the results reported by others, whereas the reproducibility in the most severely pathological areas of the brain was rather poor, as regards the flow in the fast compartments. The correlation between the various flow parameters was found to be fairly good.

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgery

2002 ◽  
Vol 16 (4) ◽  
pp. 273-277 ◽  
Author(s):  
Suzuka Taki ◽  
Kotaro Higashi ◽  
Manabu Oguchi ◽  
Hiroyasu Tamamura ◽  
Shiro Tsuji ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Stereotactic Radiosurgery ◽  
Regional Cerebral Blood Flow ◽  
Normal Brain ◽  
Regional Cerebral Blood

Compartmental abnormalities of regional cerebral blood flow in children with head trauma

1972 ◽  
Vol 36 (4) ◽  
pp. 463-470 ◽  
Author(s):  
Samuel S. Kasoff ◽  
Lawrence H. Zingesser ◽  
Kenneth Shulman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Gray Matter ◽  
Regional Cerebral Blood Flow ◽  
Head Injuries ◽  
Relative Weight ◽  
Compartmental Analysis ◽  
Regional Cerebral Blood ◽  
Content Type ◽  
Pediatric Age Group

✓ Regional cerebral blood flow (CBFr) and compartmental analysis in a series of children with closed head injuries have demonstrated abnormalities of both rate and distribution of blood flow. The most frequent derangement was a triphasic flow pattern overlying one or more regions of traumatized brain. The rate of flow in this third compartment is two to five times the rate of normal gray matter flow; while the relative weight of the compartment varies between 3.5% and 15%. The pathophysiology of this third, rapid compartment of flow is discussed, and the argument put forth that such flow does not represent hyperperfusion but rather an ischemia of the gray matter because such blood flow is not available to the tissue for nutrition. If this is so, it may well be a cause of permanent sequelae in the pediatric age group.

scholarly journals Chroma-Memo-Flow Technique for Rapid Sequential Analysis of Regional Cerebral Blood Flow (rCBF) Responses

1978 ◽  
Vol 5 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jørn Overgaard
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Sequential Analysis ◽  
Initial Slope ◽  
Functional Tests ◽  
Regional Cerebral Blood ◽  
Flow Calculation ◽  
Channel Memory ◽  
Xenon 133

SUMMARY:This is the first report of a method of sequential regional cerebral blood flow (rCBF) analysis, called Croma-Memo-Flow. This technique is a computerized modification of the initial slope method of regional cerebral blood flow (rCBF init.), allowing temporal resolution of the flow pattern by calculation of the slopes of sequential segments of the initial 1-2 minutes of the Xenon-133 washout curve. The same theoretical analysis applies to this method as to the rCBF init. method. Each flow calculation is based on the slope of a discrete 16 second segment of the initial washout; and each second the segment is advanced by one second. A new flow calculation is made each second and is displayed as a color coded map on a TV screen. Each map is labelled, indicating the time in seconds following Xenon injection, and sequential rCBF changes during the clearance period can be immediately visualized. This allows for almost instantaneous analysis and display of rapid or transient rCBF responses to activation and deactivation of the cerebral cortices.The data is stored in a 35 channel memory for deliberate replay, photography, and analysis.Functional tests may be applied during the initial washout period and both the magnitude and chronological relationships of the evoked regional cerebrovascular responses observed. A clinical study is presented to illustrate the possibilities of applying the technique to assess cortical reactivity.

Personality and Regional Cerebral Blood Flow

1984 ◽  
Vol 144 (5) ◽  
pp. 529-532 ◽  
Author(s):  
Roy J. Mathew ◽  
Maxine L. Weinman ◽  
Deborah L. Barr
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Function ◽  
Regional Cerebral Blood Flow ◽  
Cortical Arousal ◽  
Regional Cerebral Blood ◽  
Capillary Perfusion ◽  
Brain Capillary ◽  
Eysenck Personality Inventory ◽  
The Brain

SummaryThe extraversion–introversion dimension of personality is believed to have an inverse relationship with cortical arousal. Brain capillary perfusion is a well established index of brain function and arousal. Regional cerebral blood flow was measured in 51 right-handed females whose personality structure was examined with the Eysenck Personality Inventory (EPI). Significant inverse correlations were found between the brain blood flow and the extraversion–introversion score of EPI.

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