Chroma-Memo-Flow Technique for Rapid Sequential Analysis of Regional Cerebral Blood Flow (rCBF) Responses

SUMMARY:This is the first report of a method of sequential regional cerebral blood flow (rCBF) analysis, called Croma-Memo-Flow. This technique is a computerized modification of the initial slope method of regional cerebral blood flow (rCBF init.), allowing temporal resolution of the flow pattern by calculation of the slopes of sequential segments of the initial 1-2 minutes of the Xenon-133 washout curve. The same theoretical analysis applies to this method as to the rCBF init. method. Each flow calculation is based on the slope of a discrete 16 second segment of the initial washout; and each second the segment is advanced by one second. A new flow calculation is made each second and is displayed as a color coded map on a TV screen. Each map is labelled, indicating the time in seconds following Xenon injection, and sequential rCBF changes during the clearance period can be immediately visualized. This allows for almost instantaneous analysis and display of rapid or transient rCBF responses to activation and deactivation of the cerebral cortices.The data is stored in a 35 channel memory for deliberate replay, photography, and analysis.Functional tests may be applied during the initial washout period and both the magnitude and chronological relationships of the evoked regional cerebrovascular responses observed. A clinical study is presented to illustrate the possibilities of applying the technique to assess cortical reactivity.

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Noninvasive Method of Estimating Human Newborn Regional Cerebral Blood Flow

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.1982.47 ◽

1982 ◽

Vol 2 (4) ◽

pp. 415-420 ◽

Cited By ~ 39

Author(s):

D. P. Younkin ◽

M. Reivich ◽

J. Jaggi ◽

W. Obrist ◽

M. Delivoria-Papadopoulos

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Gray Matter ◽

Regional Cerebral Blood Flow ◽

Relative Weight ◽

Initial Slope ◽

Noninvasive Method ◽

Regional Cerebral Blood ◽

Fractional Flow ◽

Xenon 133

A noninvasive method of estimating regional cerebral blood flow (rCBF) in premature and full-term babies has been developed. Based on a modification of the xenon-133 inhalation rCBF technique, this method uses eight extracranial NaI scintillation detectors and an i. v. bolus injection of xenon-133 (∼0.5 mCi/kg). Arterial xenon concentration was estimated with an external chest detector. Cerebral blood flow was measured in 15 healthy, neurologically normal premature infants. Using Obrist's method of two-compartment analysis, normal values were calculated for flow in both compartments, relative weight and fractional flow in the first compartment (gray matter), initial slope of gray matter blood flow, mean cerebral blood flow, and initial slope index of mean cerebral blood flow. The application of this technique to newborns, its relative advantages, and its potential uses are discussed.

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Regional Cerebral Blood Flow during Rest and Skilled Hand Movements by Xenon-133 Inhalation and Emission Computerized Tomography

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.1981.42 ◽

1981 ◽

Vol 1 (4) ◽

pp. 385-389 ◽

Cited By ~ 34

Author(s):

Martin Lauritzen ◽

Leif Henriksen ◽

Niels A. Lassen

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Single Photon ◽

Photon Emission ◽

Hand Movements ◽

Regional Cerebral Blood ◽

Symmetric Pattern ◽

Xenon 133 ◽

The Right

Regional cerebral blood flow (CBF) was studied in 16 normal adult volunteers during rest and in 10 the study was repeated during skilled hand movements. A fast-rotating (“dynamic”), single-photon emission computerized tomograph (ECT) with four detector heads was used. Xenon-133 was inhaled over a 1-min period at a concentration of 10 mCi/L. The arrival and washout of the radioisotope was recorded during four 1-min periods. Two slices, 2 cm thick, 7 and 12 cm above the orbitomeatal line were obtained in every study. CBF averaged 60 ml/100 g/min (SD ± 11) in the lower slice and 51 ml/100 g/min (SD ± 13) in the upper slice. A symmetric pattern comparing right to left sides was found in both slices. Finger tapping and writing with the right hand increased CBF in specific areas of the upper slice: in the contralateral hand area by 35 ± 15% ( p < 0.025), and in the supplementary motor area on both sides by 34 ± 15% ( p < 0.025).

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