Mixed germ-cell tumor of the pineal region

1987 ◽  
Vol 66 (2) ◽  
pp. 300-304 ◽  
Author(s):  
Stephen L. Graziano ◽  
Frank P. Paolozzi ◽  
Alfred R. Rudolph ◽  
William A. Stewart ◽  
Ahmad Elbadawi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Serum Levels ◽  
Pineal Region ◽  
Cell Tumor ◽  
Subtotal Resection ◽  
Content Type ◽  
Mixed Germ Cell Tumor ◽  
Nongerminomatous Germ Cell Tumor ◽  
Modality Approach

✓ The case is presented of a 15-year-old boy with a mixed nongerminomatous germ-cell tumor of the pineal region associated with elevated cerebrospinal fluid and serum levels of the beta subunit of human chorionic gonadotropin. Treatment consisted of initial subtotal resection followed by radiotherapy and systemic chemotherapy with cisplatin, vinblastine, and bleomycin. The patient is alive without evidence of tumor 37 months after his initial diagnosis. A literature review of intracranial embryonal carcinoma and choriocarcinoma provided the rationale for a combined-modality approach to this otherwise lethal neoplasm.

Testicular Mixed Germ Cell Tumor with Polyembryoma Component in Brothers

2005 ◽  
Vol 8 (1) ◽  
pp. 92-97 ◽  
Author(s):  
Sevgi Bakaris ◽  
Sefa Resim ◽  
Nurdan Tunali
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Mature Teratoma ◽  
Testicular Tumor ◽  
Serum Levels ◽  
High Serum ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor ◽  
The Right

We report the case of a 17-year-old male with a testicular tumor and high serum levels of α-fetoprotein. The patient was treated with surgery followed by combination chemotherapy with bleomycin, etoposide, and cisplatin. Histologic examination showed features of a mixed germ cell tumor composed of mature teratoma, immature teratoma, embryonal carcinoma, yolk sac tumor, and polyembryoma. He is currently well, and his serum levels of α-fetoprotein have been normal more than 5 months after treatment. His brother, aged 17 years at the time, had a similar tumor removed from the right testicle 5 years previously.

Intrasellar mixed germ-cell tumor

1983 ◽  
Vol 58 (5) ◽  
pp. 766-770 ◽  
Author(s):  
Robert B. Page ◽  
Paul V. Plourde ◽  
Douglas Coldwell ◽  
James I. Heald ◽  
Joel Weinstein
Keyword(s):  
Germ Cell ◽  
Pituitary Gland ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Content Type ◽  
Mixed Germ Cell Tumor ◽  
Fine Print

✓ The case of a 19-year-old male with a pluripotential teratoma arising in the pituitary gland is presented. The clinical, radiological, and pathological aspects of this case are discussed. This case demonstrates that intracranial germinal tumors can arise from the pituitary gland as well as from the infundibular and pineal regions.

Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor

1989 ◽  
Vol 71 (4) ◽  
pp. 601-604 ◽  
Author(s):  
Jan Watterson ◽  
John R. Priest
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Whole Brain Radiotherapy ◽  
Pineal Region ◽  
Cell Tumor ◽  
High Dose ◽  
Content Type ◽  
Extraneural Metastasis ◽  
Fine Print

✓ Primary intracranial germ-cell tumors are infrequently occurring neoplasms which most often arise in the pineal or sellar regions. Germinomas are seen more frequently than nongerminomatous germ-cell tumors; they are often curable with radiotherapeutic approaches, or with chemotherapy in the rare instance of extraneural metastasis. Nongerminomatous germ-cell tumors are relatively radioresistant and when extraneural metastasis has occurred, they have been fatal in all of the 32 previously reported cases. The case of a 14-year-old girl with a mixed malignant germ-cell tumor arising in the pineal region is reported. Extraneural metastasis to the lung developed 12 months after whole-brain radiotherapy was completed. She was treated with etoposide (VP-16), high-dose cisplatin, vinblastine, and bleomycin and is currently without evidence of disease 46 months postmetastasis.

18F-FDG PET/CT Imaging for Mixed Germ Cell Tumor in the Pineal Region

2012 ◽  
Vol 37 (3) ◽  
pp. e61-e63 ◽  
Author(s):  
Soon-Ah Park ◽  
Tae Young Kim ◽  
See-Sung Choi ◽  
Chung-Yong Yang ◽  
Hun Soo Kim ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Fdg Pet ◽  
Pineal Region ◽  
Ct Imaging ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report

Neurosurgery ◽  
2005 ◽  
Vol 56 (1) ◽  
pp. E191-E194 ◽  
Author(s):  
Wenya Linda Bi ◽  
Serguei I. Bannykh ◽  
Joachim Baehring
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Mature Teratoma ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Subtotal Resection ◽  
Third Ventriculostomy ◽  
Histopathological Analysis ◽  
Growing Teratoma Syndrome ◽  
Nongerminomatous Germ Cell Tumor

Abstract OBJECTIVE AND IMPORTANCE: We report a rare complication after resection of a recurrent intracranial nongerminomatous germ cell tumor in an adult. The growing teratoma syndrome, as originally described with pediatric germ cell neoplasms, represents tumor recurrence, often cystic, that sometimes is observed after partial response to multimodality therapy and despite decreasing tumor serum markers. The enlarging tumor consists of elements of a mature teratoma that presumably are refractory to chemotherapy or radiation. To our knowledge, this is only the third case of the growing teratoma syndrome in an adult patient with nongerminomatous germ cell tumor. CLINICAL PRESENTATION: A 26-year-old man had signs of recurrent obstructive hydrocephalus 6 months after multimodality treatment of a diencephalic yolk sac tumor and endoscopic third ventriculostomy. Imaging studies revealed large multilocular cystic masses originating from the tumor bed and partially obstructing the ventriculostomy. INTERVENTION: Near total tumor resection and fenestration was performed. Histopathological analysis demonstrated a mature teratoma. CONCLUSION: Surgical resection, if feasible, is the treatment of choice for the growing teratoma syndrome to establish the correct diagnosis and prevent complications.

Mission impossible: chemotherapy in the intensive care for pineal region germ cell tumor

2021 ◽  
Author(s):  
Kanwaljeet Garg ◽  
Shashwat Mishra ◽  
Rahil Rafiq ◽  
KP Haresh ◽  
Manmohan Singh
Keyword(s):  
Intensive Care ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Pineal Region ◽  
Cell Tumor

scholarly journals Mediastinal mixed germ cell tumor: A case report and literature review

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 892-898
Author(s):  
Xianwen Hu ◽  
Dandan Li ◽  
Jinhua Xia ◽  
Pan Wang ◽  
Jiong Cai
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Yolk Sac ◽  
Immature Teratoma ◽  
Cell Tumor ◽  
Yolk Sac Tumor ◽  
Medical Attention ◽  
Ct Guided ◽  
Mixed Germ Cell Tumor

Abstract Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.

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