Effect of regional spinal cord blood flow and central control in recovery from spinal cord injury

1989 ◽  
Vol 71 (5) ◽  
pp. 747-753 ◽  
Author(s):  
B. Barry Chehrazi ◽  
Oscar Scremin ◽  
Emilio E. Decima

✓ Forty-two cats were subjected to decerebration, thoracic and lumbar laminectomies, and isolation of the sciatic nerves. Spinal evoked potentials in response to bilateral sciatic nerve stimulation were recorded at L-3, and the spinal cord blood flow (SCBF) was measured by the hydrogen clearance technique. Thoracic cordotomy did not alter the lumbar SCBF or the central conduction time as determined by spinal evoked potentials. Thoracic cordotomy significantly lowered the lumbar spinal cord injury threshold. Continuous sciatic nerve stimulation increased the lumbar SCBF in normal and traumatized animals; however, it did not affect the spinal cord injury threshold as measured by recovery of the spinal evoked potentials. It appears that rostral spinal cord integrity is far more significant in recovery from spinal cord injury than the maintenance of regional SCBF.

1978 ◽  
Vol 38 (3) ◽  
pp. 435-439 ◽  
Author(s):  
Arthur I. Kobrine ◽  
Delbert E. Evans ◽  
Hugo V. Rizzoli

Author(s):  
Robert R. Hansebout ◽  
R. Neil Lamont ◽  
M. Venkatraya Kamath

ABSTRACT:The internal spinal cord blood flow was measured in dogs at the site of local cooling using hydrogen polarography. Blood flow decreased to 50% of the normothermic values during cooling of the cord to a central temperature of 16 degrees Celsius. Upon cessation of cooling internal blood flow rapidly returned to normal values. Implications of this finding for the treatment of spinal cord injury are discussed.


2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Li-Yun Jia ◽  
An-Hui Yao ◽  
Fang Kuang ◽  
Yu-Kai Zhang ◽  
Xue-Feng Shen ◽  
...  

Shu-Xue-Tong (SXT) is a traditional Chinese drug widely used to ameliorate stagnation of blood flow, such as brain or myocardial infarction. Whether SXT may have therapeutic value for spinal cord injury (SCI), during which ischemia plays an important role in its pathology, remains to be elucidated. We hypothesized that SXT may promote SCI healing by improving spinal cord blood flow (SCBF), and a study was thus designed to explore this possibility. Twenty-five male Sprague-Dawley rats were used. SCI was induced by compression, and SXT was administrated 24 h postinjury for 14 successive days. The effects of SXT were assessed by means of laser-Doppler flowmetry, motor functional analysis (open-field walking and footprint analysis), and histological analysis (hematoxylin-eosin and thionin staining and NeuN immunohistochemistry). SXT significantly promoted SCBF of the contused spinal cord and enhanced the recovery of motor function. Histological analysis indicated that the lesion size was reduced, the pathological changes were ameliorated, and more neurons were preserved. Based on these results we conclude that SXT can effectively improve SCI.


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