The novel element in the mechanism of endogenous regulation of depressive-like states
Keyword(s):
It was shown previously that cyclo-prolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present work it was shown that cyclo-prolylglycine at a dose of 1 mg/kg with subchronic intraperitoneal administration reduces the time of animal immobility to passive control, from 167.6 to 83.6 s on the 12th day of the experiment using the model of learned helplessness in rats. That indicates the presence of antidepressant-like activity. The results of the study allow us to consider that cyclo-prolylglycine is a link in the physiological regulation of a depressive-like state.
2021 ◽
Vol 31
(2)
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pp. 216-218
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2007 ◽
Vol 88
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pp. S242
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Keyword(s):
2012 ◽
Vol 72
(11)
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pp. 971-977
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2008 ◽
Vol 210
(1)
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pp. 109-117
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Keyword(s):
GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986
2009 ◽
Vol 16
(4)
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pp. 624-637
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