Plant expression systems for early stage discovery and development of lead therapeutic antibodies

2015 ◽  
Vol 23 (3-4) ◽  
pp. 37-43 ◽  
Author(s):  
Vikram Virdi ◽  
Paloma Juarez ◽  
Ann Depicker
Keyword(s):  
Early Stage ◽  
Therapeutic Antibodies ◽  
Expression Systems ◽  
Plant Expression ◽  
Plant Expression Systems

scholarly journals Rapid High-Level Production of Functional HIV Broadly Neutralizing Monoclonal Antibodies in Transient Plant Expression Systems

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58724 ◽  
Author(s):  
Yvonne Rosenberg ◽  
Markus Sack ◽  
David Montefiori ◽  
Donald Forthal ◽  
Lingjun Mao ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Expression Systems ◽  
Plant Expression ◽  
Plant Expression Systems ◽  
High Level ◽  
Level Production

scholarly journals Plant expression systems, a budding way to confront chikungunya and Zika in developing countries?

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2121 ◽  
Author(s):  
Jaime A. Cardona-Ospina ◽  
Juan C. Sepúlveda-Arias ◽  
L. Mancilla ◽  
Luis G. Gutierrez-López
Keyword(s):  
Developing Countries ◽  
Vaccine Design ◽  
Cost Effective ◽  
Heterologous Proteins ◽  
Expression Systems ◽  
Pharmaceutical Development ◽  
Diagnostic Kits ◽  
Plant Expression ◽  
Protein Pharmaceutical ◽  
Plant Expression Systems

Plant expression systems could be used as biofactories of heterologous proteins that have the potential to be used with biopharmaceutical aims and vaccine design. This technology is scalable, safe and cost-effective and it has been previously proposed as an option for vaccine and protein pharmaceutical development in developing countries. Here we present a proposal of how plant expression systems could be used to address Zika and chikungunya outbreaks through development of vaccines and rapid diagnostic kits.

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