Predicting Affective Cognitions in the Resting Adult Brain

Impairment of adult brain neurogenesis alters hippocampus-dependent behavioural tasks without reducing learning ability

PsycEXTRA Dataset ◽

10.1037/e516232012-015 ◽

2011 ◽

Author(s):

P. Jedynak ◽

R. K. Filipkowski ◽

L. Kaczmarek

Keyword(s):

Adult Brain ◽

Learning Ability

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Reducing stress, improving physical activity, and building peer support for young adult brain tumor survivors

PsycEXTRA Dataset ◽

10.1037/e548132012-153 ◽

2010 ◽

Author(s):

Stacia Wagner ◽

Tamika Wong

Keyword(s):

Physical Activity ◽

Brain Tumor ◽

Young Adult ◽

Peer Support ◽

Adult Brain ◽

Reducing Stress

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Role of melatonin in regulating neurogenesis: Implications for the neurodegenerative pathology and analogous therapeutics for Alzheimer’s disease

Melatonin Research ◽

10.32794/mr11250059 ◽

2020 ◽

Vol 3 (2) ◽

pp. 216-242 ◽

Cited By ~ 1

Author(s):

Mayuri Shukla ◽

Areechun Sotthibundhu ◽

Piyarat Govitrapong

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Adult Neurogenesis ◽

Adult Brain ◽

Therapeutic Approaches ◽

Therapeutic Implications ◽

Cell Proliferation And Differentiation ◽

Proliferation And Differentiation ◽

Progenitor Cell Proliferation

The revelation of adult brain exhibiting neurogenesis has established that the brain possesses great plasticity and that neurons could be spawned in the neurogenic zones where hippocampal adult neurogenesis attributes to learning and memory processes. With strong implications in brain functional homeostasis, aging and cognition, various aspects of adult neurogenesis reveal exuberant mechanistic associations thereby further aiding in facilitating the therapeutic approaches regarding the development of neurodegenerative processes in Alzheimer’s Disease (AD). Impaired neurogenesis has been significantly evident in AD with compromised hippocampal function and cognitive deficits. Melatonin the pineal indolamine augments neurogenesis and has been linked to AD development as its levels are compromised with disease progression. Here, in this review, we discuss and appraise the mechanisms via which melatonin regulates neurogenesis in pathophysiological conditions which would unravel the molecular basis in such conditions and its role in endogenous brain repair. Also, its components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain would aid in accentuating the therapeutic implications of this indoleamine in line of prevention and treatment of AD.

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