scholarly journals Bone Regeneration Using Collagenated Synthetic Bone Graft Attached to Collagen Membrane with 3,4-dihydroxy-L-phenylalanine (DOPA)

2021 ◽  
Vol 25 (1) ◽  
pp. 10-21
Author(s):  
Inpyo Hong ◽  
Renchindorj Dolgorsuren ◽  
Su-Hee Jeon ◽  
Young Woo Song ◽  
Jae-Kook Cha ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Collagen Membrane ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

scholarly journals A Clinical Report of Bone Regeneration in Maxillofacial Surgery using Bonelike ® Synthetic Bone Graft

2008 ◽  
Vol 22 (4) ◽  
pp. 373-385 ◽  
Author(s):  
R.C. Sousa ◽  
J.V. Lobato ◽  
A.C. Maurício ◽  
N.S. Hussain ◽  
C.M. Botelho ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Maxillofacial Surgery ◽  
Clinical Report ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

scholarly journals Multiple Porous Synthetic Bone Graft Comprising Engineered Micro-Channel for Drug Carrier and Bone Regeneration

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5320
Author(s):  
Chun-Sik Bae ◽  
Seung-Hyun Kim ◽  
Taeho Ahn ◽  
Yeonji Kim ◽  
Se-Eun Kim ◽  
...  
Keyword(s):  
Sustained Release ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Grafts ◽  
Channel Structure ◽  
Bovine Bone ◽  
Micro Channel ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Different Types

Due to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements. In this study, two different types of bone grafts were tested for their drug carrying abilities along with their osteogenic properties. Two different types of alendronate-loaded bone grafts, Bio-Oss (bovine bone graft) and InRoad (biphasic synthetic bone graft) were observed to see how different concentrations of alendronate would affect the sustained release to enhance osteogenesis. In this study, defected ovariectomize-induced osteoporotic rat calvarias were observed for 28 days with three different concentrations of alendronate (0 mg, 1 mg, 5 mg) for both Bio-Oss and InRoad. A higher concentration (5 mg) allowed for a more controlled and sustained release throughout the 28-day comparison to those of lower concentrations (0 mg, 1 mg). When comparing Bio-Oss and InRoad through histology and Micro-CT, InRoad showed higher enhancement in osteogenesis. Through this study, it was observed that alendronate not only brings out robust osteogenesis with InRoad bone grafts, but also enhances bone regeneration in an alendronate-concentration-dependent manner. The combination of higher concentration of alendronate and multiple porous bone graft containing internal micro-channel structure of InRoad resulted in higher osteogenesis with a sustained release of alendronate.

scholarly journals 405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Aljawadi ◽  
I Madhi ◽  
T Naylor ◽  
M Elmajee ◽  
A Islam ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Thickness ◽  
Bone Graft Substitute ◽  
Fracture Site ◽  
Open Fractures ◽  
X Rays ◽  
Radiographic Images ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

scholarly journals Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

2016 ◽  
Vol 25 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Zorica Buser ◽  
Darrel S. Brodke ◽  
Jim A. Youssef ◽  
Hans-Joerg Meisel ◽  
Sue Lynn Myhre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Comparative Studies ◽  
Functional Outcomes ◽  
Retrospective Studies ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

Comparison of SLA®or SLActive®implants placed in the maxillary sinus with or without synthetic bone graft materials - an animal study in sheep

2013 ◽  
Vol 25 (10) ◽  
pp. 1142-1148 ◽  
Author(s):  
Alexander Philipp ◽  
Warwick Duncan ◽  
Malgorzata Roos ◽  
Christoph H. Hämmerle ◽  
Thomas Attin ◽  
...  
Keyword(s):  
Bone Graft ◽  
Maxillary Sinus ◽  
Animal Study ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

scholarly journals Survival Analysis after Core Decompression in Association with Platelet-Rich Plasma, Mesenchymal Stem Cells, and Synthetic Bone Graft in Patients with Osteonecrosis of the Femoral Head

Joints ◽  
2018 ◽  
Vol 06 (01) ◽  
pp. 016-022 ◽  
Author(s):  
Riccardo D'Ambrosi ◽  
Elena Biancardi ◽  
Giulia Massari ◽  
Vincenza Ragone ◽  
Renato Facchini
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Femoral Head ◽  
Bone Graft ◽  
Platelet Rich Plasma ◽  
Core Decompression ◽  
Stage I ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Kaplan Meier

Purpose The aim of this study was to report the rate of survivorship in patients with osteonecrosis of the femoral head treated with core decompression in association with mesenchymal stem cells (MSCs) implantation, platelet-rich plasma (PRP) injection, and synthetic bone graft. Methods We evaluated 24 hips in 16 patients, according to Ficat classification, treated by core decompression, injection of PRP and MSCs, and backfilling of the core tract with synthetic bone graft. Survivorship was estimated using Kaplan–Meier curves. Results The survivorship of core decompression in association with the procedure is 50% at 75 months of follow-up. The survival rate was 80% for patients in early stage and 28.6% for patients in advanced stage at 75 months. When we compared Kaplan–Meier survival curves of patients in stage III + IV and patients in stage I + II, we noticed that the survival functions are statistically different (p < 0.05, log-rank test), particularly in stage I + II where we had a greater surviving core decompression, in comparison to patients in stage III + IV. Conclusion This technique is safe and good preliminary results were obtained in patients with early stages of the disease with no reported complications. Level of Evidence Level IV, therapeutic case series.

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