OCULAR MANIFESTATIONS IN SYSTEMIC LUPUS ERYTHAMATUSUS PATIENTS: A HOSPITAL BASED OBSERVATIONAL STUDY.

Objectives: This study was to evaluate the incidence and ocular manifestation in systemic lupus erythematosus (SLE) patients. Methods: A total of 50 cases with age group 15 to 50 years were enrolled. A detail history, clinical examinations and relevant investigations were performed to all cases. Patients who were diagnosed with systemic lupus erythamatusus (SLE) by using American Rheumatologic criteria with or without ocular features were included in this study. Results: Data was analysed by using simple statistical methods with the help of MS-office software. All data was tabulated and percentage was calculated. Conclusions: Females were commonly suffered with systemic lupus erythamatusus (SLE) and it was commonly seen in age 15-25 years. Episcleritis was the most common symptoms in SLE. Second most common symptoms were conjunctivitis and scleritis. Right eye was more affected than left eye. Most of the cases had ANA positive. Hence, ocular manifestation is the most common in SLE patients. Early diagnosis and prompt treatment may give light of hope for SLE patients. And more research is needed in order to determine which therapy will provide the best prevention and management in SLE patients. Key words: Systemic lupus erythamatusus (SLE), ocular manifestation, age group, ANA-positive.

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Eye and Rheumatology

Skills in Rheumatology ◽

10.1007/978-981-15-8323-0_19 ◽

2021 ◽

pp. 419-428

Author(s):

Abdullah A Al-ghamdi

Keyword(s):

Systemic Lupus Erythematosus ◽

Juvenile Idiopathic Arthritis ◽

Lupus Erythematosus ◽

Visual Loss ◽

Ocular Involvement ◽

Ocular Manifestation ◽

Systemic Lupus ◽

Systemic Involvement ◽

Rheumatologic Diseases ◽

Ocular Manifestations

AbstractThe ocular involvement in rheumatology can be in a wide variety; it ranges from simple episcleritis to significant visual loss. Early detection followed by appropriate management can reserve vision. Ophthalmic involvement may occur in all of the rheumatic disorders. Ocular manifestation may be a presenting sign in some disorders, as in juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), and Sjogren’s syndrome (SjS), or can be a presenting sign with the systemic involvement as in systemic lupus erythematosus (SLE), polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), and systemic sclerosis. Thus ocular manifestations in rheumatologic diseases (Table 19.1) can be the link in approaching the diagnosis.

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Lymphopenia Helps Early Diagnosis of Systemic Lupus Erythematosus for Patients With Psychosis as an Initial Symptom

Psychosomatics ◽

10.1016/j.psym.2013.07.001 ◽

2015 ◽

Vol 56 (1) ◽

pp. 85-88 ◽

Cited By ~ 1

Author(s):

Yuhei Chiba ◽

Omi Katsuse ◽

Hiroshige Fujishiro ◽

Ayuko Kamada ◽

Tomoyuki Saito ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Early Diagnosis ◽

Lupus Erythematosus ◽

Initial Symptom ◽

Systemic Lupus

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Systemic Lupus Erythematosus

10.2310/tywc.1049 ◽

2019 ◽

Author(s):

Kyriakos A. Kirou ◽

Michael D. Lockshin

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Sun Exposure ◽

Disease Classification ◽

Discoid Lupus Erythematosus ◽

Neurologic Disease ◽

Systemic Lupus ◽

Nuclear Antigens ◽

Key Words Systemic Lupus

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune illness characterized by autoantibodies directed at nuclear antigens that cause clinical and laboratory abnormalities, such as rash, arthritis, leukopenia and thrombocytopenia, alopecia, fever, nephritis, and neurologic disease. Most or all of the symptoms of acute lupus are attributable to immunologic attack on the affected organs. Many complications of long-term disease are attributable to both the disease and its treatment. Intense sun exposure, drug reactions, and infections are circumstances that induce flare; the aim of treatment is to induce remission. This chapter is divided into sections dealing with SLE’s definitions; epidemiology; pathogenesis; disease classification, diagnosis, and differential diagnosis; and treatment. This review contains 10 figures, 12 tables, and 97 references. Key Words: Systemic lupus erythematosus, Dermatomyositis, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, Discoid lupus erythematosus, truncal psoriasiform, annular polycyclic rash

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Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review

Lupus ◽

10.1177/09612033211050337 ◽

2021 ◽

pp. 096120332110503

Author(s):

Nitish Jawahar ◽

Jessica K Walker ◽

Philip I Murray ◽

Caroline Gordon ◽

John A Reynolds

Keyword(s):

Systematic Review ◽

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Systemic Disease ◽

Retinal Vasculitis ◽

Small Sample ◽

Systemic Lupus ◽

Ocular Manifestations ◽

Ophthalmic Manifestations

Objective Ophthalmic complications in Systemic Lupus Erythematosus (SLE) are broad and can occur in up to a third of patients. The British Isles Lupus Assessment Group (BILAG) 2004 Index identifies 13 ocular manifestations of active SLE, as opposed to those related to previous disease activity and/or the consequences of therapy. We conducted a systematic review of published literature to determine the frequency of ophthalmic manifestations of active SLE. Methods A systematic literature search of Ovid MEDLINE and EMBASE from their respective inceptions to July 2020 was conducted to identify cohort, case–control and cross-sectional studies. Results 22 studies meeting eligibility criteria were included. Most studies featured small sample sizes and were judged to have a high risk of methodological bias. The number and quality of studies did not allow us to confidently estimate the incidence of the conditions. No studies reported epidemiological data for orbital inflammation/myositis/proptosis. The prevalence of each of the other ocular manifestations, with the exception of retinal vaso-occlusive disease, was consistently less than 5%. Retinal vasculitis, uveitis and isolated cotton wool spots tended to be associated with more active SLE disease. Conclusion The prevalence of eye disease due to SLE activity is uncommon, but clinicians should be aware that some conditions tend to be associated with more active systemic disease. Further studies to determine the incidence and risk factors for these ophthalmic manifestations are needed.

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Systemic Lupus Erythematosus in the Older Age Group: Computer Analysis

Journal of the American Geriatrics Society ◽

10.1111/j.1532-5415.1979.tb03342.x ◽

1979 ◽

Vol 27 (2) ◽

pp. 58-61 ◽

Cited By ~ 32

Author(s):

JACOB DIMANT ◽

ELLEN M. GINZLER ◽

MICHAEL SCHLESINGER ◽

HERBERT S. DIAMOND ◽

DAVID KAPLAN

Keyword(s):

Systemic Lupus Erythematosus ◽

Computer Analysis ◽

Lupus Erythematosus ◽

Older Age ◽

Age Group ◽

Systemic Lupus

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Early Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus by Deep Learning Enhanced Magnetic Resonance Spectroscopy

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3378 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1341-1347

Author(s):

Xin Li ◽

Lu Bai ◽

Zuhao Ge ◽

Zhizhe Lin ◽

Xi Yang ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Magnetic Resonance ◽

Early Diagnosis ◽

Magnetic Resonance Spectroscopy ◽

Lupus Erythematosus ◽

Support Vector ◽

Resonance Spectroscopy ◽

Systemic Lupus ◽

Proton Mrs ◽

Neuropsychiatric Systemic Lupus Erythematosus

The neuropsychiatric systemic lupus erythematosus (NPSLE) has higher disability and mortality rates, which is one of the main causes of death in systemic lupus erythematosus (SLE) patients. Magnetic resonance spectroscopy (MRS) can detect the changes of metabolites in different intracranial areas in vivo in patients with SLE, so as to provide evidence for the early diagnosis of NPSLE. Different from the conventional single-voxel MRS, which can only screen one brain region with one metabolic change, we simultaneously detect 13 kinds of intracranial metabolic changes in nine brain regions by multivoxel proton MRS (MVS). We use a recursive feature elimination algorithm to select the most related metabolites for better identifying NPSLE. To accurately diagnosis NPSLE by these intracranial metabolites, we train a support vector machine deep stacked network (SVM-DSN) for quantitative analysis of these metabolites. Comparing with the conventional statistic method, which is about 70% of accuracy, the proposed model achieves 97.5% of accuracy for NPSLE diagnosis. We conclude the trained SVM-DSN can effectively analyze the metabolites obtained by multivoxel proton MRS for NPSLE diagnosis, which may help to early diagnosis and intervention of NPSLE, and alleviate the bias of manual screening.

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