scholarly journals Preeclampsia as a Risk Factor for Damage of the Cochlear Outer Hair Cells Function

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Oppy Surya Atmaja ◽  
Kartono Sudarman ◽  
Agus Surono
Keyword(s):  
Hair Cells ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Blood Pressure Measurement ◽  
Otoacoustic Emission ◽  
Organ Damage ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Multisystem Disorder ◽  
Distortion Product

Preeclampsia is one of the most common complications of pregnancy in the world. In Indonesia, the incidence of preeclampsia lies within 3–10% of all pregnancies every year. Preeclampsia is a multisystem disorder that causes endothelial dysfunction and vasospasm that may lead to ischemia and organ damage especially to the end organs. Cochlea serves as an end organ and is therefore vulnerable to damage under ischemic conditions. This research aimed to understand the role of preeclampsia on the destruction of cochlear outer hair cells function. Subjects were pregnant women who were hospitalized in the Obstetrics and Gynecology Ward of Sardjito Hospital. Diagnosis of preeclampsia was obtained by defining level of high blood pressure measurement and quantitative 24 hours of proteinuria. Meanwhile, cochlear outer hair cell function was measured by the distortion product otoacoustic emission (DPOAE). The DPOAE results showed that REFER presented in 6 (10%) patients with preeclampsia and none in those without preeclampsia groups. This result demonstrated preeclampsia as one of the risk factors for impaired function of cochlear outer hair cells.

Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Asti Kristianti ◽  
Teti Madiadipoera ◽  
Bogi Soeseno
Keyword(s):  
Hair Cells ◽  
Malignant Neoplasm ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
High Dose ◽  
Distortion Product Otoacoustic Emission ◽  
Inclusion Criteria ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

2015 ◽  
Vol 129 (12) ◽  
pp. 1174-1181 ◽  
Author(s):  
N Wooles ◽  
M Mulheran ◽  
P Bray ◽  
M Brewster ◽  
A R Banerjee
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

scholarly journals Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice

2021 ◽  
Vol 13 ◽  
Author(s):  
Leslie K. Climer ◽  
Aubrey J. Hornak ◽  
Kaitlin Murtha ◽  
Yang Yang ◽  
Andrew M. Cox ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cell Function ◽  
Otoacoustic Emission ◽  
Cell Types ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Age Related ◽  
Brainstem Response

Ca2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca2+ binding protein (CaBP) preferentially expressed in outer hair cells (OHCs) of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM delays hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of Ocm leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of Ocm reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated age-related hearing loss (ARHL) of the Ocm KO illustrates the importance of Ca2+ signaling in maintaining hearing health. Manipulation of OCM and Ca2+ signaling may reveal important clues to the systems of function/dysfunction that lead to ARHL.

scholarly journals Oncomodulin Delays Age-Related Hearing Loss in C57 and CBA Mice

2021 ◽  
Author(s):  
Leslie K Climer ◽  
Aubrey J Hornak ◽  
Kaitlin Murtha ◽  
Yang Yang ◽  
Andrew M Cox ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cell Function ◽  
Otoacoustic Emission ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Progressive Hearing Loss ◽  
Distortion Product ◽  
Age Related ◽  
Brainstem Response

Ca2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca2+ binding protein preferentially expressed in outer hair cells of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM prevents early progressive hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of Ocm leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of Ocm reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated ARHL of the Ocm KO illustrates the importance of Ca2+ signaling in maintaining hearing health.

scholarly journals Effect of Using N95 and Surgical Masks on Otoacoustic Emission in Cochlear Outer Hair Cells

2021 ◽  
pp. 014556132110346
Author(s):  
Sedat Alagoz ◽  
Kemal Koray Bal ◽  
Talih Ozdas ◽  
Vedat Delibas ◽  
Gokhan Kuran ◽  
...  
Keyword(s):  
Hair Cells ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Surgical Masks ◽  
Before And After ◽  
Group 2 ◽  
The Right ◽  
Group 1

Introduction: Distortion product otoacoustic emission (DPOAE) was measured to investigate the effect of mask use and type on oxygen saturation on cochlear function in health care professionals during the COVID-19 pandemic. Material and Methods: Group 1 participants wore surgical masks; Group 2 participants wore N95 masks. Distortion product otoacoustic emission and oxygen saturation were measured in both groups before and after mask use. Results: Comparison of signal-to-noise ratio (SNR) values before and after surgical mask use in DPOAE measurements of group 1 revealed statistically significant difference in the right and left ears. Comparison of the SNR values in DPOAE measurements of group 2 before and after 8 hours of N95 mask use revealed statistically significant differences in the right ear at 988, 2963, 4444, and 8000 Hz and in the left ear at 8000 Hz. Conclusion: We found that prolonged mask use may affect the outer hair cells in the cochlea, causing deterioration in DPOAE values.

scholarly journals Evaluation of outer hair cells function of non-operated ear after mastoid drilling using distortion-product otoacoustic emissions

2019 ◽  
Vol 5 (3) ◽  
pp. 130-133
Author(s):  
Virender Singh ◽  
◽  
BS Rakesh ◽  
MB Bharathi ◽  
Kota Harish Nag ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emissions ◽  
Mechanical Trauma ◽  
Suppurative Otitis Media ◽  
Distortion Product ◽  
Study Materials ◽  
And Gender

Aim: To analyze the effect of acoustic and mechanical trauma of drilling on the outer hair cell function of the non operated ear using distortion-product otoacoustic emissions (DPOAE’s) after mastoidectomy and its relation with the duration of drilling, age, and gender of the patient along with duration and permanency of the effects. Study Design: Observational study. Materials and Methods: Screening DPOAE’s were recorded preoperatively, immediate postoperative period, one hour postoperatively, 1st and 7th postoperative days in the normal ear in 94 patients who underwent tympanomastoidectomy for unilateral chronic suppurative otitis media (CSOM). DPOAE’s were measured using Neuro-audio-screener (Neurosoft Inc.) at 1.5 KHz, 2.1 KHz, 3.3 KHz, and 4.2 KHz. If DPOAE’s were absent preoperatively, the patients were not evaluated further and patients who had absent DPOAE’s post-operatively were successively followed till DPOAE’s were regained. Results: Of the 94 patients included, in 62 patients DPOAE’s were present preoperatively. Out of these 62, in 30 patients DPOAE’s were absent immediate postoperatively. On repeat testing, DPOAE’s were absent in 20 patients after 1 hour and in 8 patients after 1 day. On re-evaluation of these 8 patients after 1 week all of them had regained the DPOAE’s. In terms of duration of drilling, 66.6% patients in immediate post operative period, 90% patients in 1-hour post operative and 100 % patients on post operative day 1, having absent DPOAE’s had drilling time more than 60 minutes. Patients more than 30 years of age are affected more, but there is no preponderance for any gender. Conclusion: Nonoperated ear does have the effect of acoustic and mechanical trauma by vibration transmitted from another side during drilling of the operative ear mastoid bone. This effect is temporary and depends on the duration of drilling also.

scholarly journals Correlation between schroeder-phase effect and distortion product otoacoustic emission findings

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Nur Baizura Salahuddin ◽  
Sarah Rahmat
Keyword(s):  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
Output Function ◽  
Distortion Product Otoacoustic Emission ◽  
Input Output ◽  
Phase Effect ◽  
Cochlear Function ◽  
Distortion Product ◽  
Effect Mechanism

Introduction: Schroeder-phase masking has been proven to be more sensitive than pure tone audiometry in detecting changes in cochlear function. Schroeder harmonic complexes with different phases have been observed to excite basilar membranes differently and give different masking abilities (‘phase effect’) when used as maskers. Previous theory suggested that phase effect was contributed by cochlear non-linearity of outer hair cells (OHC); however the theory was derived from behavioral observation alone. Therefore, this study aims to further investigate the cochlear non-linearity involvement in phase effect mechanism by measuring the Schroeder phase effect together with another electrophysiological test that measures the cochlear non-linearity function, i.e. Distortion Product Otoacoustic Emission (DPOAE). Methods: Twelve normal hearing and four sensorineural hearing loss subjects were recruited. Schroeder phase masking test was conducted and phase effect (using 75 dB A masker) at 1kHz and 2 kHz was measured. DPOAE was recorded at multiple intensities (45-75 dB SPL) for 1 kHz and 2 kHz, and slope of DPOAE input output function was measured. Correlation analysis was performed to find correlation between phase effect and slope of DPOAE input output function. Results: Result showed no significant correlation (p > 0.05) between phase effect and slope of DPOAE input output function. Conclusions: This findings suggest that Schroeder-phase effect may not be/ may not only be contributed by OHC’s cochlear non-linearity. This finding opens the possibility of other auditory functions’ involvement in phase effect mechanism, and contribute to better understanding towards auditory perceptions.

Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study

2021 ◽  
pp. 1-13
Author(s):  
Selis Gulseven Guven ◽  
Onur Ersoy ◽  
Ruhan Deniz Topuz ◽  
Erdoğan Bulut ◽  
Gulnur Kizilay ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Outer Hair Cell ◽  
Monosodium Glutamate ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Control Group ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Significant Difference ◽  
Brainstem Response

<b><i>Introduction:</i></b> The effect of orally consumed monosodium glutamate (MSG), which is a common additive in the food industry, on the cochlea has not been investigated. The present study aimed to investigate the possible cochleotoxic effects of oral MSG in guinea pigs using electrophysiological, biochemical, and histopathological methods. <b><i>Methods:</i></b> Thirty guinea pigs were equally divided into control and intervention groups (MSG 100 mg/kg/day; MSG 300 mg/kg/day). At 1 month, 5 guinea pigs from each group were sacrificed; the rest were observed for another month. Electrophysiological measurements (distortion product otoacoustic emission [DPOAE] and auditory brainstem response [ABR]), glutamate levels in the perilymph and blood samples, and histopathological examinations were evaluated at 1 and 2 months. <b><i>Results:</i></b> Change in signal-to-noise ratio at 2 months was significantly different in the MSG 300 group at 0.75 kHz and 2 kHz (<i>p</i> = 0.013 and <i>p</i> = 0.044, respectively). There was no statistically significant difference in ABR wave latencies of the guinea pigs given MSG compared to the control group after 1 and 2 months; an increase was noted in ABR thresholds, although the difference was not statistically significant. In the MSG groups, moderate-to-severe degeneration and cell loss in outer hair cells, support cells, and spiral ganglia, lateral surface junction irregularities, adhesions in stereocilia, and partial loss of outer hair cell stereocilia were noted. <b><i>Conclusion:</i></b> MSG, administered in guinea pigs at a commonly utilized quantity and route of administration in humans, may be cochleotoxic.

Sensitivity of Distortion Product Otoacoustic Emissions in Noise-Exposed Chinchillas

2005 ◽  
Vol 16 (02) ◽  
pp. 069-078 ◽  
Author(s):  
Bob Davis ◽  
Wei Qiu ◽  
Roger P. Hamernik
Keyword(s):  
Otoacoustic Emissions ◽  
Evoked Potential ◽  
Outer Hair Cell ◽  
Otoacoustic Emission ◽  
Speech Discrimination ◽  
Distortion Product Otoacoustic Emission ◽  
Hearing Conservation ◽  
Distortion Product ◽  
Cochlear Pathology ◽  
Sensorineural Hearing Impairment

The present study investigates the effect of small amounts of outer hair cell (OHC) loss on distortion product otoacoustic emission (DPOAE) levels and evoked potential permanent threshold shifts (PTS) in a population of 12 noise-exposed chinchillas. The group mean DPOAE level, which decreased by up to ~15 dB in the presence of less than 8 dB PTS and 15% OHC loss, indicates that DPOAEs can detect an underlying cochlear pathology (i.e., OHC damage/loss) despite the presence of normal to near normal thresholds. The sensitivity of DPOAEs in detecting OHC loss makes this test measure suited for diagnosing sensorineural hearing impairment, particularly when abnormal auditory symptoms (i.e., speech discrimination problems) are associated with a normal audiogram in the clinical setting and as part of a hearing conservation program.

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