scholarly journals Impulsive and Compulsive Behaviors in Parkinson's Disease:

2014 ◽  
Vol 4 (1) ◽  
pp. 37-41
Author(s):  
Abdulraheem M. Alshehri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Case Series ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Compulsive Eating ◽  
Dopamine Dysregulation Syndrome ◽  
Current Thinking ◽  
Compulsive Behaviors

Parkinson's disease is a common neurodegenerative disease, with a worldwide incidence of about 10-20 in 100,000. Its diagnosis remains clinical, and it requires bradykinesia plus one of the following: Rest tremor, rigidity or postural instability. Dopaminergic therapy including levodopa and dopamine agonists has allowed a reasonable control over the motor symptoms, but it offered no help for the non-motor manifestations. To the contrary, dopaminergic antiparkinson therapy was the most likely culprit in the emergence of a new set of impulse control disorders including:  Pathological gambling, hypersexuality, compulsive shopping, compulsive eating, punding (complex, repetitive, excessive, non-goal oriented behaviors), walkabout, and dopamine dysregulation syndrome. A case series of three main impulse control disorders in Parkinson's disease is presented here with a review of the current thinking regarding diagnosis and treatment.

scholarly journals Impulsive and Compulsive Behaviors in Parkinson's Disease:

2014 ◽  
Vol 4 (1) ◽  
pp. 37-41
Author(s):  
Abdulraheem M. Alshehri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Case Series ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Compulsive Eating ◽  
Dopamine Dysregulation Syndrome ◽  
Current Thinking ◽  
Compulsive Behaviors

Parkinson's disease is a common neurodegenerative disease, with a worldwide incidence of about 10-20 in 100,000. Its diagnosis remains clinical, and it requires bradykinesia plus one of the following: Rest tremor, rigidity or postural instability. Dopaminergic therapy including levodopa and dopamine agonists has allowed a reasonable control over the motor symptoms, but it offered no help for the non-motor manifestations. To the contrary, dopaminergic antiparkinson therapy was the most likely culprit in the emergence of a new set of impulse control disorders including:  Pathological gambling, hypersexuality, compulsive shopping, compulsive eating, punding (complex, repetitive, excessive, non-goal oriented behaviors), walkabout, and dopamine dysregulation syndrome. A case series of three main impulse control disorders in Parkinson's disease is presented here with a review of the current thinking regarding diagnosis and treatment.

scholarly journals Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies

2021 ◽  
Vol 12 ◽  
Author(s):  
Jun-Fang Zhang ◽  
Xi-Xi Wang ◽  
Ya Feng ◽  
Robert Fekete ◽  
Joseph Jankovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Broad Spectrum ◽  
Impulse Control ◽  
Compulsive Buying ◽  
Therapeutic Strategies ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Disease Epidemiology ◽  
Tremendous Impact

Impulse control disorders (ICDs) in Parkinson's disease (PD) are aberrant behavior such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically occur as a result of dopaminergic therapy. Numerous studies have focused on the broad spectrum of ICDs-related behaviors and their tremendous impact on patients and their family members. Recent advances have improved our understanding of ICDs. In this review, we discuss the epidemiology, pathogenesis and treatment of ICDs in the setting of PD.

“He Wants It All the Time, Doctor”

2016 ◽  
Author(s):  
Robertus M. A. de Bie
Keyword(s):  
Behavioral Change ◽  
Impulse Control ◽  
Disease Onset ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Compulsive Shopping ◽  
Compulsive Eating ◽  
Dopamine Dysregulation Syndrome ◽  
Factors Associated ◽  
History Of

Impulse-control disorders are an increasingly recognized complication of dopaminergic therapy in Parkinson’s disease, being present in approximately 15% of patients treated with dopamine agonists but also observed in patients treated with levodopa (referred to as “dopamine dysregulation syndrome”). Impulse-control disorders include pathological gambling, hypersexuality, compulsive shopping, and compulsive eating. Factors associated with a higher risk for impulse-control disorders are a young age at disease onset, a history of addictive behavior before the disease started, a family history of addiction such as alcoholism, and being male. It is undoubtedly true that current estimates are conservative due to embarrassment or shame preventing patients from disclosing behavioral change to their doctors. All patients must be questioned about impulse-control disorders at every visit, and where possible a collateral should be obtained from a family member or carer.

scholarly journals Screening for Problematic Internet Use May Help Identify Impulse Control Disorders in Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Márton Kovács ◽  
Attila Makkos ◽  
Dávid Pintér ◽  
Annamária Juhász ◽  
Gergely Darnai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Internet Use ◽  
Screening Method ◽  
Impulse Control Disorders ◽  
Problematic Internet Use ◽  
Screening Methods ◽  
Compulsive Behaviors ◽  
Excessive Internet Use

Background. Impulse control disorders in Parkinson’s disease (PD) represent emerging problems with potentially devastating consequences. The standard screening methods for impulse control disorders are clinically imperfect. Although it is rarely reported, many patients utilize the Internet to fulfill their compulsive behaviors because of its easy accessibility. We designed a study to test the hypothesis that an active screening for excessive Internet use and Internet addiction might improve the sensitivity of identification of impulse control disorders. Methods. The standard screening method included the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease and the modified Minnesota Impulsive Disorders Interview. In the second round, the Problematic Internet Use Questionnaire was also assessed for detecting excessive Internet use. Results. While the standard approach identified 19 patients out of 106 (17.9%) with any type of impulse control disorders, screening for the problematic Internet use detected 29 patients with impulse control disorders (27.4%) having significantly better efficacy over the standard method (p=0.004, the McNemar test). Conclusions. Our study suggests that the screening for problematic Internet use by the Problematic Internet Use Questionnaire is an effective, feasible, and easy-to-use add-on method for identifying PD patients with impulse control disorders more efficiently and probably at earlier stages.

Impulsivity in Patients with Parkinson’s Disease

2017 ◽  
Vol 10 (1) ◽  
pp. 3-8
Author(s):  
Rumyana N. Kuzmanova ◽  
Irina Ts. Stefanova ◽  
Katerina I. Stambolieva
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sexual Behaviour ◽  
Impulse Control ◽  
Dopamine Agonists ◽  
Negative Impact ◽  
Compulsive Shopping ◽  
Compulsive Eating ◽  
Dopamine Dysregulation Syndrome ◽  
Compulsive Behaviour

SummaryIn recent years focus has been increasingly placed on impulse control disorders (ICDs) in patients with Parkinson’s disease (PD). ICDs include pathological attraction to gambling, compulsive shopping, compulsive eating and compulsive sexual behaviour and are associated mostly with the intake of dopamine agonists. Another impulsive and compulsive behaviour in PD is the dopamine dysregulation syndrome, which is associated with compulsive intake of L-dopa, and short-acting dopamine agonists. Diagnostics and prevention of this group of disorders is essential, considering the difficulties related to their treatment and their negative impact on the patients themselves as well as on their relatives.

scholarly journals Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

2021 ◽  
Vol 15 ◽  
Author(s):  
Andrea Augustine ◽  
Catharine A. Winstanley ◽  
Vaishnav Krishnan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Neurodegenerative Disorder ◽  
Impulse Control Disorders ◽  
Special Focus ◽  
Motor Impairments ◽  
Dopamine Agonist Therapy ◽  
Compulsive Behaviors

Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by symptoms that impact both motor and non-motor domains. Outside of motor impairments, PD patients are at risk for impulse control disorders (ICDs), which include excessively disabling impulsive and compulsive behaviors. ICD symptoms in PD (PD + ICD) can be broadly conceptualized as a synergistic interaction between dopamine agonist therapy and the many molecular and circuit-level changes intrinsic to PD. Aside from discontinuing dopamine agonist treatment, there remains a lack of consensus on how to best address ICD symptoms in PD. In this review, we explore recent advances in the molecular and neuroanatomical mechanisms underlying ICD symptoms in PD by summarizing a rapidly accumulating body of clinical and preclinical studies, with a special focus on the utility of rodent models in gaining new insights into the neurochemical basis of PD + ICD. We also discuss the relevance of these findings to the broader problem of impulsive and compulsive behaviors that impact a range of neuropsychiatric syndromes.

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