scholarly journals Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

2021 ◽  
Vol 15 ◽  
Author(s):  
Andrea Augustine ◽  
Catharine A. Winstanley ◽  
Vaishnav Krishnan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Neurodegenerative Disorder ◽  
Impulse Control Disorders ◽  
Special Focus ◽  
Motor Impairments ◽  
Dopamine Agonist Therapy ◽  
Compulsive Behaviors

Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by symptoms that impact both motor and non-motor domains. Outside of motor impairments, PD patients are at risk for impulse control disorders (ICDs), which include excessively disabling impulsive and compulsive behaviors. ICD symptoms in PD (PD + ICD) can be broadly conceptualized as a synergistic interaction between dopamine agonist therapy and the many molecular and circuit-level changes intrinsic to PD. Aside from discontinuing dopamine agonist treatment, there remains a lack of consensus on how to best address ICD symptoms in PD. In this review, we explore recent advances in the molecular and neuroanatomical mechanisms underlying ICD symptoms in PD by summarizing a rapidly accumulating body of clinical and preclinical studies, with a special focus on the utility of rodent models in gaining new insights into the neurochemical basis of PD + ICD. We also discuss the relevance of these findings to the broader problem of impulsive and compulsive behaviors that impact a range of neuropsychiatric syndromes.

Impulse-Control Disorders in Parkinson's Disease

CNS Spectrums ◽  
2008 ◽  
Vol 13 (8) ◽  
pp. 690-698 ◽  
Author(s):  
Joseph M. Ferrara ◽  
Mark Stacy
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Replacement Therapy ◽  
Impulse Control ◽  
Neurodegenerative Disorder ◽  
Psychosocial Impairment ◽  
Olfactory Loss ◽  
Dopamine Replacement Therapy ◽  
Compulsive Behaviors ◽  
Non Motor Symptoms

ABSTRACTParkinson's disease is a neurodegenerative disorder characterized by bradykinesia, rigidity, postural instability, and resting tremor. Increasingly, Parkinson's disease has been associated with a broad spectrum of non-motor symptoms, such as olfactory loss, sleep disorders, autonomic dysfunction, cognitive impairment, psychosis, depression, anxiety, and apathy. In addition, a minority of Parkinson's disease patients develop compulsive behaviors while receiving dopamine-replacement therapy, including medication hoarding, pathological gambling, binge eating, hyperlibidinous behavior, compulsive shopping, and punding. These behaviors may result in psychosocial impairment for patients and therapeutic challenges for clinicians. This article reviews the anatomic substrates, behavioral spectrum, associated factors, and potential treatments for dopamine-replacement therapy-related compulsions in Parkinson's disease.

Past smoking and current dopamine agonist use show an independent and dose-dependent association with impulse control disorders in Parkinson's disease

2013 ◽  
Vol 19 (7) ◽  
pp. 698-700 ◽  
Author(s):  
Guilherme T. Valença ◽  
Philip G. Glass ◽  
Nadja N. Negreiros ◽  
Meirelayne B. Duarte ◽  
Lais M.G.B. Ventura ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Dose Dependent

scholarly journals Impulsive and Compulsive Behaviors in Parkinson's Disease:

2014 ◽  
Vol 4 (1) ◽  
pp. 37-41
Author(s):  
Abdulraheem M. Alshehri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Case Series ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Compulsive Eating ◽  
Dopamine Dysregulation Syndrome ◽  
Current Thinking ◽  
Compulsive Behaviors

Parkinson's disease is a common neurodegenerative disease, with a worldwide incidence of about 10-20 in 100,000. Its diagnosis remains clinical, and it requires bradykinesia plus one of the following: Rest tremor, rigidity or postural instability. Dopaminergic therapy including levodopa and dopamine agonists has allowed a reasonable control over the motor symptoms, but it offered no help for the non-motor manifestations. To the contrary, dopaminergic antiparkinson therapy was the most likely culprit in the emergence of a new set of impulse control disorders including:  Pathological gambling, hypersexuality, compulsive shopping, compulsive eating, punding (complex, repetitive, excessive, non-goal oriented behaviors), walkabout, and dopamine dysregulation syndrome. A case series of three main impulse control disorders in Parkinson's disease is presented here with a review of the current thinking regarding diagnosis and treatment.

Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study

2014 ◽  
Vol 85 (8) ◽  
pp. 840-844 ◽  
Author(s):  
P. J. Garcia-Ruiz ◽  
J. C. Martinez Castrillo ◽  
A. Alonso-Canovas ◽  
A. Herranz Barcenas ◽  
L. Vela ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multicentre Study ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Impulse Control Disorder ◽  
Agonist Therapy ◽  
Dopamine Agonist Therapy

scholarly journals Impulsive and Compulsive Behaviors in Parkinson's Disease:

2014 ◽  
Vol 4 (1) ◽  
pp. 37-41
Author(s):  
Abdulraheem M. Alshehri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Case Series ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Compulsive Eating ◽  
Dopamine Dysregulation Syndrome ◽  
Current Thinking ◽  
Compulsive Behaviors

Parkinson's disease is a common neurodegenerative disease, with a worldwide incidence of about 10-20 in 100,000. Its diagnosis remains clinical, and it requires bradykinesia plus one of the following: Rest tremor, rigidity or postural instability. Dopaminergic therapy including levodopa and dopamine agonists has allowed a reasonable control over the motor symptoms, but it offered no help for the non-motor manifestations. To the contrary, dopaminergic antiparkinson therapy was the most likely culprit in the emergence of a new set of impulse control disorders including:  Pathological gambling, hypersexuality, compulsive shopping, compulsive eating, punding (complex, repetitive, excessive, non-goal oriented behaviors), walkabout, and dopamine dysregulation syndrome. A case series of three main impulse control disorders in Parkinson's disease is presented here with a review of the current thinking regarding diagnosis and treatment.

scholarly journals Screening for Problematic Internet Use May Help Identify Impulse Control Disorders in Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Márton Kovács ◽  
Attila Makkos ◽  
Dávid Pintér ◽  
Annamária Juhász ◽  
Gergely Darnai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Internet Use ◽  
Screening Method ◽  
Impulse Control Disorders ◽  
Problematic Internet Use ◽  
Screening Methods ◽  
Compulsive Behaviors ◽  
Excessive Internet Use

Background. Impulse control disorders in Parkinson’s disease (PD) represent emerging problems with potentially devastating consequences. The standard screening methods for impulse control disorders are clinically imperfect. Although it is rarely reported, many patients utilize the Internet to fulfill their compulsive behaviors because of its easy accessibility. We designed a study to test the hypothesis that an active screening for excessive Internet use and Internet addiction might improve the sensitivity of identification of impulse control disorders. Methods. The standard screening method included the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease and the modified Minnesota Impulsive Disorders Interview. In the second round, the Problematic Internet Use Questionnaire was also assessed for detecting excessive Internet use. Results. While the standard approach identified 19 patients out of 106 (17.9%) with any type of impulse control disorders, screening for the problematic Internet use detected 29 patients with impulse control disorders (27.4%) having significantly better efficacy over the standard method (p=0.004, the McNemar test). Conclusions. Our study suggests that the screening for problematic Internet use by the Problematic Internet Use Questionnaire is an effective, feasible, and easy-to-use add-on method for identifying PD patients with impulse control disorders more efficiently and probably at earlier stages.

Apathy and impulse control disorders association: A study in a sample of Parkinson's disease patients

2016 ◽  
Vol 33 (S1) ◽  
pp. S396-S396
Author(s):  
N. Sáez-Francàs ◽  
N. Ramirez ◽  
J. Alegre-Martin ◽  
O. De Fabregues ◽  
J. Alvarez-Sabin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Trait Anxiety ◽  
Impulse Control ◽  
Rating Scale ◽  
Neurodegenerative Disorder ◽  
Linear Regression Analysis ◽  
Impulse Control Disorders ◽  
Hamilton Depression Scale ◽  
Wide Range

IntroductionParkinson's disease (PD) is a neurodegenerative disorder that is associated with a wide range of motor symptoms, cognitive deficits and behavioral disorders. Apathy and impulse control disorders (ICDs) are common in these patients and have been considered opposite ends of a reward and motivation disorders continuum.AimTo evaluate the association and impact of ICDs presence on apathy symptoms in PDs patients, considering the influence of other psychopathological symptoms on this association.MethodsThis is a cross-sectional, observational study in which 115 consecutive medicated PD patients without dementia (mean age 61.22 ± 13.5 years; 63.5% men) were recruited. All the patients underwent a psychiatric and neurologic evaluation. Motor dysfunction was assessed with the Unified Parkinson's disease Rating Scale (UPDRS), ICDs were evaluated with the Minnesota Impulse Control Disorders Inventory (MIDI) and apathy with the Lille Apathy Scale (LARS). The Hamilton Depression scale (HAM-D). The State-Trait Anxiety Inventory (STAI-S) and Barrat Impulsivity Scale (BIS) were also administrated.ResultsTwenty-seven (23.5%) patients showed an ICD. Patients with an ICD scored higher in apathy (P = 0.012), trait anxiety (P = 0.003) and impulsivity (P = 0.008). There were no differences in depressive symptoms. In the linear regression analysis, TCI was associated with more severe apathy (b = 4.20, t = 2.15, P = 0.034).ConclusionsICDs and apathy are frequent in PD. Although ICDs have been related with a hyperdopaminergic state and apathy with low dopamine levels, the observed frequent association suggests common etiopathological mechanisms.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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