Successful therapy of endotoxin shock and multiple organ dysfunction using sequential targeted extracorporeal treatment in a patient after combined cardiac surgery

2020 ◽  
Vol 8 (2) ◽  
pp. 105-114
Author(s):  
M.A. Babaev ◽  
◽  
A.A. Eremenko ◽  
O.O. Grin ◽  
N.S. Kostritсa ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Organ Dysfunction ◽  
Endotoxin Shock ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Successful Therapy ◽  
Extracorporeal Treatment

scholarly journals 1657 Mortality in Post-Cardiac Surgery in Children: The role of Multiple Organ Dysfunction

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A469-A469
Author(s):  
T. d. Rocha ◽  
A. Botta ◽  
C. Ricachinevsky ◽  
L. Mulle ◽  
P. Carvalho
Keyword(s):  
Cardiac Surgery ◽  
Organ Dysfunction ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Post Cardiac Surgery

Barrier Function of the Gut and Multiple Organ Dysfunction after Cardiac Surgery

2007 ◽  
Vol 35 (1) ◽  
pp. 72-83 ◽  
Author(s):  
J-P Braun ◽  
S Buhner ◽  
M Kastrup ◽  
E Dietz ◽  
K Langer ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Organ Dysfunction ◽  
Barrier Function ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

scholarly journals MONITORING OF CENTRAL HEMODYNAMICS IN PATIENTS WITH MULTIPLE ORGAN DYSFUNCTION SYNDROME

2021 ◽  
Vol 19 (2) ◽  
pp. 187-193
Author(s):  
S. A. Tachyla ◽  
◽  
V. A. Dudko ◽  
A. V. Marochkov ◽  
A. A. Bondarenko ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Abdominal Surgery ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Infusion Therapy ◽  
Multiple Organ Dysfunction ◽  
Central Hemodynamics ◽  
End Diastolic Volume ◽  
Central Hemodynamic

Objective: comparative analysis of the use of PiCCO monitoring for correction of the intensive care in patients with multiple organ dysfunction syndrome (MODS) after abdominal and cardiac surgery. Material and methods. A prospective cohort study was carried out in 19 patients with MODS after abdominal (n=10) and cardiac (n=9) interventions. Of these, 13 men and 6 women, aged 63 (58-69) years, their height was 176 (174-180) cm, body weight - 90 (80-100) kg. Central hemodynamic parameters were monitored in these patients by the PiCCO method. Several steps have been distinguished in the study: 1st stage - 1st day after surgery, 2nd stage - 2nd day after surgery, etc. Results. In patients after cardiac surgery, compared with the group of patients after abdominal surgery, significantly (p <0.001) lower preload indices (global end-diastolic volume and index, intrathoracic blood volume and index) were noted at 1-2 stages, as well as significantly (p<0.05) lower rates of contractility (continuous cardiac output and index at 1-4 stages, stroke volume and index at 1-5 stages). When analyzing the treatment in patients after cardiac surgery, the frequency of dobutamine use (p=0.017) and the frequency of simultaneous use of 3 vasoactive substances (p=0.0495) were statistically significantly higher than in patients undergoing abdominal surgery. Conclusions. Monitoring of central hemodynamics enables to individualize infusion therapy, vasopressor and inotropic support in patients with MODS after abdominal and cardiac surgery.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

Multiple Organ Dysfunction Syndrome of Alcoholic Origin in an 18-Year-Old Patient

2018 ◽  
Vol 2 (12) ◽  
Author(s):  
Francesco Gazia ◽  
Giacomo De Luca ◽  
Imbalzano Gabriele ◽  
Vincenzo Pellicanò
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury

2019 ◽  
Vol 131 (6) ◽  
pp. 1931-1937 ◽  
Author(s):  
Sungho Lee ◽  
Hyunsoo Hwang ◽  
Jose-Miguel Yamal ◽  
J. Clay Goodman ◽  
Imoigele P. Aisiku ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Sofa Score ◽  
Plasma Concentrations ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Poor Outcome ◽  
Initial Plasma

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS.METHODSThe authors performed a secondary analysis of a recent randomized clinical trial studying the effects of erythropoietin and blood transfusion threshold on neurological recovery after TBI. Admission clinical, demographic, laboratory, and imaging parameters were used in a multivariable Cox regression analysis to identify independent risk factors for MODS following TBI, defined as maximum total Sequential Organ Failure Assessment (SOFA) score > 7 within 10 days of TBI.RESULTSTwo hundred patients were initially recruited and 166 were included in the final analysis. Respiratory dysfunction was the most common nonneurological organ system dysfunction, occurring in 62% of the patients. International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) probability of poor outcome at admission was significantly associated with MODS following TBI (odds ratio [OR] 8.88, 95% confidence interval [CI] 1.94–42.68, p < 0.05). However, more commonly used measures of TBI severity, such as the Glasgow Coma Scale, Injury Severity Scale, and Marshall classification, were not associated with post-TBI MODS. In addition, initial plasma concentrations of interleukin (IL)–6, IL-8, and IL-10 were significantly associated with the development of MODS (OR 1.47, 95% CI 1.20–1.80, p < 0.001 for IL-6; OR 1.26, 95% CI 1.01–1.58, p = 0.042 for IL-8; OR 1.77, 95% CI 1.24–2.53, p = 0.002 for IL-10) as well as individual organ dysfunction (SOFA component score ≥ 1). Finally, MODS following TBI was significantly associated with mortality (OR 5.95, 95% CI 2.18–19.14, p = 0.001), and SOFA score was significantly associated with poor outcome at 6 months (Glasgow Outcome Scale score < 4) when analyzed as a continuous variable (OR 1.21, 95% CI 1.06–1.40, p = 0.006).CONCLUSIONSAdmission IMPACT probability of poor outcome and initial plasma concentrations of IL-6, IL-8, and IL-10 were associated with MODS following TBI.

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