Effect of Tramadol on Ovine Ureteral Smooth Muscle Contractility: an in Vitro Experimental Study

2013 ◽  
Vol 11 (1) ◽  
Keyword(s):  
Experimental Study ◽  
Smooth Muscle ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility

Lack Of Effect Of IL-22 On Human Airway Smooth Muscle Contractility In Vitro

2012 ◽  
Author(s):  
Adrian R. West ◽  
Jennifer Frazer ◽  
Tiesong Li ◽  
Geoffrey N. Maksym ◽  
Elizabeth Cowley
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Human Airway

scholarly journals Decreased airway narrowing and smooth muscle contraction in hyperresponsive pigs

2002 ◽  
Vol 93 (4) ◽  
pp. 1296-1300 ◽  
Author(s):  
Debra J. Turner ◽  
Peter B. Noble ◽  
Matthew P. Lucas ◽  
Howard W. Mitchell
Keyword(s):  
Smooth Muscle ◽  
Airway Hyperresponsiveness ◽  
Porcine Model ◽  
Smooth Muscle Contraction ◽  
Airway Wall ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Airway Narrowing

Increased smooth muscle contractility or reduced smooth muscle mechanical loads could account for the excessive airway narrowing and hyperresponsiveness seen in asthma. These mechanisms were investigated by using an allergen-induced porcine model of airway hyperresponsiveness. Airway narrowing to electric field stimulation was measured in isolated bronchial segments, over a range of transmural pressures (0–20 cmH2O). Contractile responses to ACh were measured in bronchial segments and in isolated tracheal smooth muscle strips isolated from control and test (ovalbumin sensitized and challenged) pigs. Test airways narrowed less than controls ( P < 0.0001). Test pigs showed reduced contractility to ACh, both in isolated bronchi ( P < 0.01) and smooth muscle strips ( P < 0.01). Thus isolated airways from pigs exhibiting airway hyperresponsiveness in vivo are hyporesponsive in vitro. The decreased narrowing in bronchi from hyperresponsive pigs may be related to decreased smooth muscle contractility. These data suggest that mechanisms external to the airway wall may be important to the hyperresponsive nature of sensitized lungs.

Gastric smooth muscle contractility changes in the esophageal atresia rat model: an in vitro study

2003 ◽  
Vol 38 (9) ◽  
pp. 1366-1370 ◽  
Author(s):  
Melih Tugay ◽  
Fürüzan Yildiz ◽  
Tijen Utkan ◽  
Yusuf Sarıoglu ◽  
Nejat Gacar
Keyword(s):  
Smooth Muscle ◽  
Esophageal Atresia ◽  
Rat Model ◽  
In Vitro Study ◽  
Vitro Study ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Gastric Smooth Muscle

scholarly journals Smooth muscle contractility causes the gut to grow anisotropically

2019 ◽  
Vol 16 (159) ◽  
pp. 20190484 ◽  
Author(s):  
Diana Khalipina ◽  
Yusuke Kaga ◽  
Nicolas Dacher ◽  
Nicolas R. Chevalier
Keyword(s):  
Smooth Muscle ◽  
Squeezing Effect ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Circular Smooth Muscle ◽  
Growth Defects ◽  
Mechanical Deformations ◽  
Set Up ◽  
Innovative Culture

The intestine is the most anisotropically shaped organ, but, when grown in culture, embryonic intestinal stem cells form star- or sphere-shaped organoids. Here, we present evidence that spontaneous tonic and phasic contractions of the circular smooth muscle of the embryonic gut cause short-timescale elongation of the organ by a purely mechanical, self-squeezing effect. We present an innovative culture set-up to achieve embryonic gut growth in culture and demonstrate by three different methods (embryological, pharmacological and microsurgical) that gut elongational growth is compromised when smooth muscle contractions are inhibited. We conclude that the cumulated short-term mechanical deformations induced by circular smooth muscle lead to long-term anisotropic growth of the gut, thus demonstrating a self-consistent way by which the function of this organ (peristalsis) directs its shape (morphogenesis). Our model correctly predicts that longitudinal smooth muscle differentiation later in embryogenesis slows down elongation, and that several mice models with defective gut smooth muscle contractility also exhibit gut growth defects. We lay out a comprehensive scheme of forces acting on the gut during embryogenesis and of their role in the morphogenesis of this organ. This knowledge will help design efficient in vitro organ growth protocols and handle gut growth pathologies such as short bowel syndrome.

MP33-05 IN VITRO STUDY ON URETERAL SMOOTH MUSCLE CONTRACTILITY WITH TAMSULOSIN, NIFEDIPINE, AND TERPENE MIXTURE (ROWATINEX¢Ç)

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Jea Whan Lee ◽  
Tae Hoon Oh ◽  
Whi-An Kwon ◽  
Seung Chol Park ◽  
Hee Jong Jeong ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
In Vitro Study ◽  
Vitro Study ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility
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