scholarly journals Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: a retrospective study from the EBMT-SAA working party

Haematologica ◽  
2010 ◽  
Vol 95 (6) ◽  
pp. 976-982 ◽  
Author(s):  
A. Bacigalupo ◽  
G. Socie' ◽  
E. Lanino ◽  
A. Prete ◽  
F. Locatelli ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Antithymocyte Globulin ◽  
Low Dose ◽  
Working Party ◽  
Severe Aplastic Anemia ◽  
Alternative Donor ◽  
Total Body ◽  
Acquired Severe Aplastic Anemia

High-dose cyclophosphamide compared with antithymocyte globulin for treatment of acquired severe aplastic anemia

2013 ◽  
Vol 41 (4) ◽  
pp. 328-334 ◽  
Author(s):  
Fengkui Zhang ◽  
Li Zhang ◽  
Liping Jing ◽  
Kang Zhou ◽  
Huijun Wang ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Antithymocyte Globulin ◽  
Severe Aplastic Anemia ◽  
High Dose ◽  
Acquired Severe Aplastic Anemia

scholarly journals Prevention of graft rejection following bone marrow transplantation

Blood ◽  
1981 ◽  
Vol 57 (1) ◽  
pp. 9-12
Author(s):  
RP Gale ◽  
W Ho ◽  
S Feig ◽  
R Champlin ◽  
A Tesler ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Total Body Irradiation ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Low Dose ◽  
Conditioning Regimen ◽  
Actuarial Survival ◽  
Total Body

Bone marrow transplantation from an HLA-identical sibling is increasingly used in the treatment of severe aplastic anemia. One major problem with this approach is graft rejection that occurs in 25%-60% of patients conditioned for transplantation with cyclophosphamide. At most transplant centers it has been difficult to accurately identify patients at high risk for graft rejection. We studied a conditioning regimen of cyclophosphamide (200 mg per kg) and low-dose total body irradiation (3 Gy; equivalent to 300 rad) in 23 consecutive unselected patients with aplastic anemia followed for a minimum of 6 mo. There was only one episode of graft rejection. Graft-versus-host disease and interstitial pneumonitis were not increased by the more intensive conditioning regimen. Actuarial survival was 61% at 1 yr and 49% at 2.5 yr. Cyclophosphamide and low-dose total body irradiation is an effective conditioning regimen in patients with aplastic anemia. It may be particularly useful when accurate predictive tests of graft rejection are not available as is the case in most transplant centers.

Sign in / Sign up

Export Citation Format

Share Document