scholarly journals Multicentric Castleman Disease - An Unusual Presentation

2013 ◽  
Vol 19 (1) ◽  
pp. 53-57
Author(s):  
Arunabha Chakravarti ◽  
Meenakshi Mishra ◽  
Anita Nangia ◽  
Jatinder Kumar Sahni

Castleman disease is a rare clinicopathological disorder associated with lymphoproliferation. We report the case of a 54 year old gentleman initially presenting with dysphagia followed by bilateral cervical lymphadenopathy, and later diagnosed as multicentric Castleman disease. To the best of our knowledge no case of Castleman disease presenting as dysphagia along with neck swelling has been previously described in the literature. This case report highlights a very unusual presentation of this rare disease. It also provides insight into the fact that because of the lack of any specific presenting symptoms and distinguishing radiographic features, an accurate histopathologic diagnosis and careful staging become crucial to planning treatment for this disease. DOI: http://dx.doi.org/10.3329/bjo.v19i1.12041 Bangladesh J Otorhinolaryngol 2013; 19(1): 53-57

2019 ◽  
Vol 13 (3) ◽  
Author(s):  
Antonella Smedile ◽  
Francesca Capuano ◽  
Sara Fraticelli ◽  
Marco Lucioni ◽  
Alfredo La Fianza

2014 ◽  
Vol 27 (1) ◽  
pp. 174-177 ◽  
Author(s):  
Yasumori Izumi ◽  
Hayato Takeshita ◽  
Yuji Moriwaki ◽  
Keiko Hisatomi ◽  
Masakazu Matsuda ◽  
...  

2017 ◽  
Vol 26 (4) ◽  
pp. 338-341 ◽  
Author(s):  
Aditya Shivane ◽  
Amy Pearce ◽  
Nadia Khatib ◽  
Mark E. F. Smith

We report a case of EBV+ and HHV-8+ multicentric Castleman disease with plasmablastic aggregates in an HIV-positive individual. A 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be HIV positive. Investigations showed cervical lymphadenopathy and splenomegaly. He was treated for HIV and his symptoms resolved. His symptoms recurred in January 2016, and a provisional diagnosis of multicentric Castleman disease was entertained. The HHV-8 (human herpesvirus-8) and EBV (Epstein-Barr virus) viral load was elevated. A left supraclavicular lymph node core biopsy was performed, which showed features of multicentric Castleman disease with plasmablastic aggregates that are EBV (EBER) and HHV-8 positive. He responded well to rituximab treatment and remains well with no symptoms at recent follow-up.


2018 ◽  
Vol 90 (3) ◽  
pp. 232-236 ◽  
Author(s):  
Yumi Yamada ◽  
Toshinori Ueno ◽  
Taisuke Irifuku ◽  
Ayumu Nakashima ◽  
Shigehiro Doi ◽  
...  

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