Evaluation of The Macular and Choroidal Perfusion in Healthy Turkish Population Using Optical Coherence Tomography Angiography

Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal perfusion state in vivo. This study aimed to evaluate the acute effects of isometric and dynamic exercise on retinal and choroidal sublayer perfusion using OCTA. A pilot study was conducted on young, healthy participants, each of whom performed a specific isometric exercise on the first day and a dynamic exercise the day after. At baseline and immediately after the exercise, heart rate (HR), mean arterial pressure (MAP), superficial capillary plexus perfusion (SCPP), deep capillary plexus perfusion (DCPP), choriocapillaris perfusion (CCP), Sattlers’s layer perfusion (SLP), and Haller’s layer perfusion (HLP) were recorded. A total of 34 eyes of 34 subjects with a mean age of 32.35 ± 7.87 years were included. HR as well as MAP increased significantly after both types of exercise. Both SCPP and DCPP did not show any significant alteration due to isometric or dynamic exercise. After performing dynamic exercise, CCP, SLP, as well as HLP significantly increased. Changes in MAP correlated significantly with changes in HLP after the dynamic activity. OCTA-based analysis in healthy adults following physical activity demonstrated a constant retinal perfusion, supporting the theory of autoregulatory mechanisms. Dynamic exercise, as opposed to isometric activity, significantly changed choroidal perfusion. OCTA imaging may represent a novel and sensitive tool to expand the diagnostic spectrum in the field of sports medicine.

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Choroidal Vascular Changes in Acute Idiopathic Maculopathy as Demonstrated by Multimodal Imaging including Optical Coherence Tomography Angiography

Case Reports in Ophthalmological Medicine ◽

10.1155/2021/6680020 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Tahsin Khundkar ◽

Syed R. Hasan ◽

Mark P. Breazzano ◽

Constance Mei ◽

Brandon B. Johnson

Keyword(s):

Optical Coherence Tomography ◽

Multimodal Imaging ◽

Optical Coherence Tomography Angiography ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Optical Coherence ◽

Vascular Changes ◽

Paracentral Scotoma ◽

The Right ◽

Choroidal Perfusion

Purpose. To present a case of acute idiopathic maculopathy (AIM) and illustrate primary choroidal perfusion defect using multimodal imaging. Case Description. We report a case of a 24-year-old man with a paracentral scotoma of the right eye and recent flu-like illness. The patient was found to have a unilateral ovoid-shaped, placoid lesion just inferior to the fovea. Multimodal imaging confirmed findings most consistent with a diagnosis of acute idiopathic maculopathy (AIM). Serologic studies confirmed a strongly positive immunoglobulin G (IgG) titer for coxsackievirus A. Spectral-domain optical coherence tomography angiography (SD-OCTA) showed bilateral areas of vascular reduction at the level of the choriocapillaris and choroid, sparing the retinal circulation. Conclusions and Importance. The changes in outer retina and retinal pigment epithelium, classically described in AIM, are likely secondary to choroidal hypoperfusion.

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Peripapillary Retinal and Choroidal Perfusion in Nonarteritic Ischemic Optic Neuropathy Using Optical Coherence Tomography Angiography

Optometry and Vision Science ◽

10.1097/opx.0000000000001550 ◽

2020 ◽

Vol 97 (8) ◽

pp. 583-590

Author(s):

Rebika Dhiman ◽

Rohan Chawla ◽

Shorya Vardhan Azad ◽

Pawan Kumar ◽

Vinay Gupta ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Neuropathy ◽

Optical Coherence Tomography Angiography ◽

Ischemic Optic Neuropathy ◽

Optical Coherence ◽

Choroidal Perfusion

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Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.19-27977 ◽

2019 ◽

Vol 60 (14) ◽

pp. 4865

Author(s):

Sonja G. Karst ◽

Hannes Beiglboeck ◽

Raffael Scharinger ◽

Elias L. Meyer ◽

Christoph Mitsch ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Swept Source ◽

Choroidal Perfusion

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Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-020-01649-5 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Felix Rommel ◽

David Prangel ◽

Michelle Prasuhn ◽

Salvatore Grisanti ◽

Mahdy Ranjbar

Keyword(s):

Optical Coherence Tomography ◽

Systemic Sclerosis ◽

Optical Coherence Tomography Angiography ◽

Clinical Evidence ◽

Disease Duration ◽

Cross Sectional Study ◽

Ocular Involvement ◽

Optical Coherence ◽

Cross Sectional ◽

Choroidal Perfusion

Abstract Purpose To investigate the correlation between retinal and choroidal microperfusion in patients with systemic sclerosis (SSc) using optical coherence tomography angiography (OCTA). Methods In this cross-sectional study SSc patients without clinical evidence of ocular involvement and healthy, age- and sex-matched volunteers were recruited. Participants underwent specific rheumatological and ophthalmological examinations, including optical coherence tomography (OCT) and OCTA. Retinal and choroidal thicknesses as well as perfusion of the retina and the choroidal sublayers were evaluated. Results A total of 15 SSc patients (30 eyes) with a median disease duration of 60 months and 15 matched, healthy controls (30 eyes) were recruited. OCT data revealed a significantly lower macular volume, as well as Sattler’s layer and Haller’s layer thickness in SSc patients compared to controls. In OCTA analysis, the perfusion of both retinal plexus as well as Sattler’s and Haller’s layer were significantly reduced in the SSc group. Patients with a disease duration of more than 60 months showed a statistically significant positive correlation between retinal and choroidal malperfusion, while those with a shorter disease duration did not. Conclusion OCTA analysis confirmed impairment of retinal and choroidal microperfusion in SSc patients, supporting the hypothesis of wide spreading vascular injury. In early stages, either the retinal or the choroidal perfusion seems to be involved, while later on, vascular impairment affects both tissues alike. Both, retinal and choroidal examinations should be considered as soon as the diagnosis of SSc is made, to avoid missing out on early alterations.

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