scholarly journals The Significance of Gastric Juice Analysis for a Positive Challenge by a Standard Oral Challenge Test in Typical Cow's Milk Protein-Induced Enterocolitis

2008 ◽  
Vol 23 (2) ◽  
pp. 251 ◽  
Author(s):  
Jin-Bok Hwang ◽  
Jeong-Yoon Song ◽  
Yu Na Kang ◽  
Sang Pyo Kim ◽  
Seong-Il Suh ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Milk Protein ◽  
Challenge Test ◽  
Oral Challenge ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Oral Challenge Test ◽  
Cow’S Milk Protein ◽  
Gastric Juice Analysis

scholarly journals Consensus statement on the epidemiology, diagnosis, prevention, and management of cow's milk protein allergy in the Middle East: a modified Delphi-based study

2021 ◽  
Author(s):  
Moustafa A. El-Hodhod ◽  
Mortada H. F. El-Shabrawi ◽  
Ahmed AlBadi ◽  
Ahmed Hussein ◽  
Ali Almehaidib ◽  
...  
Keyword(s):  
Middle East ◽  
Nutritional Status ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Persistent Symptoms ◽  
Modified Delphi ◽  
Oral Challenge Test ◽  
Red Flag ◽  
Cow’S Milk Protein

Abstract Background This study aimed to develop an expert consensus regarding the epidemiology, diagnosis, and management of cow’s milk protein allergy (CMPA) in the Middle East. Methods A three-step modified Delphi method was utilized to develop the consensus. Fifteen specialized pediatricians participated in the development of this consensus. Each statement was considered a consensus if it achieved an agreement level of ≥ 80%. Results The experts agreed that the double-blind placebo-controlled oral challenge test (OCT) should be performed for 2–4 weeks using an amino acid formula (AAF) in formula-fed infants or children with suspected CMPA. Formula-fed infants with confirmed CMPA should be offered a therapeutic formula. The panel stated that an extensively hydrolyzed formula (eHF) is indicated in the absence of red flag signs. At the same time, the AAF is offered for infants with red flag signs, such as severe anaphylactic reactions. The panel agreed that infants on an eHF with resolved symptoms within 2–4 weeks should continue the eHF with particular attention to the growth and nutritional status. On the other hand, an AAF should be considered for infants with persistent symptoms; the AAF should be continued if the symptoms resolve within 2–4 weeks, with particular attention to the growth and nutritional status. In cases with no symptomatic improvements after the introduction of an AAF, other measures should be followed. The panel developed a management algorithm, which achieved an agreement level of 90.9%. Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East.

Screening for Cow Milk Allergy Among Young Egyptian Children

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Zeinab A El-Sayed ◽  
Rasha H El-Owaidy ◽  
Hanan M Abd El-Lateef ◽  
Ahmed SA Hammouda
Keyword(s):  
Milk Protein ◽  
Clinical History ◽  
Cow Milk ◽  
Cow’S Milk ◽  
Published Data ◽  
Cow's Milk ◽  
Oral Challenge Test ◽  
Egyptian Children ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Abstract Background There are insufficient published data on the prevalence of cow's milk protein allergy (CMPA) in Egypt. Aim of the Work The study aims to estimate the frequency of CMPA among young Egyptian children in a trial to delineate the magnitude of the problem in our population. Methods A cross-sectional, observational study was conducted on 500 young Egyptian children from the general population aged from 6 months to 5 years; 200 males and 300 females. Children were subjected to history taking and clinical examination. Suspected cases with suggestive clinical history of CMPA were subjected to skin prick test (SPT) with standardized cow’s milk protein allergen extract and open oral challenge test (OCT). Results In the present study, 6.2% of screened children had positive clinical history suggestive of CMPA, 35.5% of them had positive SPT and 51.6% had positive OCT. Based on clinical history and OCT, 3.2% were documented to have CMPA, 3% had undocumented CMPA or low probability of CMPA and 93.8% had no CMPA. The highest rate of initial onset of CMPA is seen before the first year of life (96.8%) and 81.3% of children with positive OCT were formula/mixed-fed. The clinical manifestations in infants with suspected CMPA were variable, and the main presenting feature was gastrointestinal tract manifestations (42%). The IgE-mediated CMPA was more common and constituted 56.3% of the CMPA cases. Conclusion The frequency of CMPA among Egyptian children up to 5 years of age is comparable to the reported frequencies worldwide. IgE-mediated CMPA accounts for more than 2/3 of the patients with proven CMPA in this study.

Risk prediction of severe reaction to oral challenge test of cow’s milk

2018 ◽  
Vol 178 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Takahiro Kawahara ◽  
Junichiro Tezuka ◽  
Takahito Ninomiya ◽  
Satoshi Honjo ◽  
Natsuko Masumoto ◽  
...  
Keyword(s):  
Risk Prediction ◽  
Challenge Test ◽  
Oral Challenge ◽  
Cow’S Milk ◽  
Severe Reaction ◽  
Cow's Milk ◽  
Oral Challenge Test

Health and growth indices in children with cow’s milk protein allergy depending on oral tolerance development

2020 ◽  
pp. 33-37
Author(s):  
A. A. Galimova ◽  
E. E. Emelyashenkov ◽  
S. G. Makarova ◽  
N. N. Murashkin ◽  
A. P. Fisenko ◽  
...  
Keyword(s):  
Milk Protein ◽  
Challenge Test ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Growth Indices ◽  
Tolerance Development ◽  
Lower Growth ◽  
Cow's Milk ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Relevance. Dairy-free diet is the basis of cow’s milk allergy (CMA) patient’s management. Duration of the diet is individual, but some children don’t develop tolerance.The aim of the study was to investigate health and growth indices in children with CMA depending on tolerance development by the age of five. Materials and methods. 153 children from 1 to 18 months with diagnosed CMA were included in the prospective study (76.5% with IgE-mediated form). The tolerance was determined after 6–12 months of a milk-free diet and at the age of 5 using an open challenge test. Anthropometry indices (Anthro Plus), levels of specific IgE (Immuno CAP 250) and IgG4 (ELISA) to dietary proteins and the presence of allergic diseases in children also were assessed.Results. 50.3% of children developed tolerance to cow’s milk protein after 6–12 months of a milk-free diet. By the age of 5 63.3% of patients had complete tolerance of dairy products. Partially formed tolerance was observed in 22.9%. 13.8% of patients still had clinical reactions to cow’s milk proteins. Patients with persistent CMA typically had IgE-mediated form, lower growth indices and multiple allergic pathology.Conclusion. The consideration of tolerance development predictors can allow to personalize the management of CMA. Additional researches are needed to clarify the causes of growth indices decline in children with persistent CMA. 

scholarly journals O5 The prevalence of cow’s milk protein allergy in infants with gastroschisis and intestinal failure type 2 and 3

2021 ◽  
Author(s):  
Kornilia Nikaki ◽  
Tracey Johnson ◽  
Haidee Norton ◽  
Gabis Chana ◽  
Amrita Garcha ◽  
...  
Keyword(s):  
Milk Protein ◽  
Intestinal Failure ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Failure Type ◽  
Cow’S Milk Protein

scholarly journals Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy

2021 ◽  
Vol 10 (8) ◽  
pp. 1595
Author(s):  
María Roca ◽  
Ester Donat ◽  
Ana Rodriguez Varela ◽  
Eva Carvajal ◽  
Francisco Cano ◽  
...  
Keyword(s):  
Milk Protein ◽  
Statistical Significance ◽  
Functional Gastrointestinal Disorders ◽  
Fecal Calprotectin ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Young Infants ◽  
Healthy Infants ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow’s milk protein allergy (CMPA) and for monitoring the infants’ response to a non-IgE mediated cow’s milk protein (CMP)-free diet. We prospectively recruited infants aged 0 to 9 months. Stool samples were taken from 30 infants with CMPA, 19 with mild functional gastrointestinal disorders, 28 healthy infants, and 28 children who presented mild infections. Despite the fact that levels of fCP and fEDN in CMPA infants were higher than in healthy infants at month 0, differences for both parameters did not reach statistical significance (p-value 0.119 and 0.506). After 1 month of an elimination diet, no statistically significant differences in fCP with basal levels were found (p-values 0.184) in the CMPA group. We found a high variability in the fCP and fEDN levels of young infants, and discrepancies in individual behavior of these markers after a CMP-free diet was started. It seems that neither fCP nor fEDN levels are helpful to discriminate between healthy infants and those with signs or symptoms related to non-IgE-mediated CMPA. Additionally, it is debatable if on an individual basis, fCP or fEDN levels could be used for clinical follow-up and dietary compliance monitoring. However, prospective studies with larger populations are needed to draw robust conclusions.

Differential Cytokine Expression in the Duodenum and Rectum of Children with Non-Immunoglobulin E-Mediated Cow’s Milk Protein Allergy

2021 ◽  
Author(s):  
Erick M. Toro-Monjaraz ◽  
Gabriela Fonseca-Camarillo ◽  
Flora Zárate-Mondragón ◽  
Ericka Montijo-Barrios ◽  
José Cadena-León ◽  
...  
Keyword(s):  
Milk Protein ◽  
Immunoglobulin E ◽  
Cytokine Expression ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Protein
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