scholarly journals Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy

2021 ◽  
Vol 10 (8) ◽  
pp. 1595
Author(s):  
María Roca ◽  
Ester Donat ◽  
Ana Rodriguez Varela ◽  
Eva Carvajal ◽  
Francisco Cano ◽  
...  
Keyword(s):  
Milk Protein ◽  
Statistical Significance ◽  
Functional Gastrointestinal Disorders ◽  
Fecal Calprotectin ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Young Infants ◽  
Healthy Infants ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow’s milk protein allergy (CMPA) and for monitoring the infants’ response to a non-IgE mediated cow’s milk protein (CMP)-free diet. We prospectively recruited infants aged 0 to 9 months. Stool samples were taken from 30 infants with CMPA, 19 with mild functional gastrointestinal disorders, 28 healthy infants, and 28 children who presented mild infections. Despite the fact that levels of fCP and fEDN in CMPA infants were higher than in healthy infants at month 0, differences for both parameters did not reach statistical significance (p-value 0.119 and 0.506). After 1 month of an elimination diet, no statistically significant differences in fCP with basal levels were found (p-values 0.184) in the CMPA group. We found a high variability in the fCP and fEDN levels of young infants, and discrepancies in individual behavior of these markers after a CMP-free diet was started. It seems that neither fCP nor fEDN levels are helpful to discriminate between healthy infants and those with signs or symptoms related to non-IgE-mediated CMPA. Additionally, it is debatable if on an individual basis, fCP or fEDN levels could be used for clinical follow-up and dietary compliance monitoring. However, prospective studies with larger populations are needed to draw robust conclusions.

Colic or Milk Allergy

PEDIATRICS ◽  
1989 ◽  
Vol 84 (5) ◽  
pp. 938-939
Author(s):  
BRUCE TAUBMAN
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Healthy Infants ◽  
Infant Colic ◽  
Excessive Crying ◽  
Cow’S Milk Protein ◽  
Definition Of ◽  
The Relationship

In the article by Drs Lothe and Lindberg, they purport to examine the relationship between infant colic and cow's milk protein allergy. However, the majority of the infants they studied did not fit the definition of infants with colic. The authors claimed the definition they used for their study corresponded to that of Wessels et al, Carey, and Schmitt. Yet, each of these physicians defined the syndrome of infant colic as excessive crying in "otherwise healthy" infants.

Faecal calprotectin as an aid to the diagnosis of non-IgE mediated cow's milk protein allergy

2016 ◽  
Vol 84 (6) ◽  
pp. 318-323 ◽  
Author(s):  
Carlos Trillo Belizón ◽  
Eduardo Ortega Páez ◽  
Antonio Medina Claros ◽  
Isabel Rodríguez Sánchez ◽  
Ana María Reina González ◽  
...  
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Faecal Calprotectin ◽  
Cow's Milk ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Screening for Cow Milk Allergy Among Young Egyptian Children

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Zeinab A El-Sayed ◽  
Rasha H El-Owaidy ◽  
Hanan M Abd El-Lateef ◽  
Ahmed SA Hammouda
Keyword(s):  
Milk Protein ◽  
Clinical History ◽  
Cow Milk ◽  
Cow’S Milk ◽  
Published Data ◽  
Cow's Milk ◽  
Oral Challenge Test ◽  
Egyptian Children ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Abstract Background There are insufficient published data on the prevalence of cow's milk protein allergy (CMPA) in Egypt. Aim of the Work The study aims to estimate the frequency of CMPA among young Egyptian children in a trial to delineate the magnitude of the problem in our population. Methods A cross-sectional, observational study was conducted on 500 young Egyptian children from the general population aged from 6 months to 5 years; 200 males and 300 females. Children were subjected to history taking and clinical examination. Suspected cases with suggestive clinical history of CMPA were subjected to skin prick test (SPT) with standardized cow’s milk protein allergen extract and open oral challenge test (OCT). Results In the present study, 6.2% of screened children had positive clinical history suggestive of CMPA, 35.5% of them had positive SPT and 51.6% had positive OCT. Based on clinical history and OCT, 3.2% were documented to have CMPA, 3% had undocumented CMPA or low probability of CMPA and 93.8% had no CMPA. The highest rate of initial onset of CMPA is seen before the first year of life (96.8%) and 81.3% of children with positive OCT were formula/mixed-fed. The clinical manifestations in infants with suspected CMPA were variable, and the main presenting feature was gastrointestinal tract manifestations (42%). The IgE-mediated CMPA was more common and constituted 56.3% of the CMPA cases. Conclusion The frequency of CMPA among Egyptian children up to 5 years of age is comparable to the reported frequencies worldwide. IgE-mediated CMPA accounts for more than 2/3 of the patients with proven CMPA in this study.

scholarly journals Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk Protein Allergy under a Restricted Diet

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1481 ◽  
Author(s):  
María Díaz ◽  
Lucía Guadamuro ◽  
Irene Espinosa-Martos ◽  
Leonardo Mancabelli ◽  
Santiago Jiménez ◽  
...  
Keyword(s):  
Food Allergy ◽  
Milk Protein ◽  
Transforming Growth Factor ◽  
Cow’S Milk ◽  
Control Group ◽  
Microbiota Composition ◽  
Fecal Samples ◽  
Cow's Milk ◽  
Healthy Infants ◽  
Cow’S Milk Protein

Cow’s milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Seventeen infants between one and two years old, diagnosed with NIM-CMPA, were recruited. They were all on an exclusion diet for six months, consuming different therapeutic protein hydrolysates. After this period, stool samples were obtained and tolerance development was evaluated by oral challenges. A control group of 10 age-matched healthy infants on an unrestricted diet were included in the study. Microbiota composition, short-chain fatty acids, calprotectin, and transforming growth factor (TGF)-β1 levels were determined in fecal samples from both groups. Infants with NIM-CMPA that consumed vegetable protein-based formulas presented microbiota colonization patterns different from those fed with an extensively hydrolyzed formula. Differences in microbiota composition and fecal parameters between NIM-CMPA and healthy infants were observed. Non-allergic infants showed a significantly higher proportion of Bacteroides compared to infants with NIM-CMPA. The type of protein hydrolysate was found to determine gut microbiota colonization and influence food allergy resolution in NIM-CMPA cases.

Patients suffering from non-IgE-mediated cow’s milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens

Allergy ◽  
2011 ◽  
Vol 66 (9) ◽  
pp. 1201-1207 ◽  
Author(s):  
H. Hochwallner ◽  
U. Schulmeister ◽  
I. Swoboda ◽  
T. E. Twaroch ◽  
H. Vogelsang ◽  
...  
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Igg Subclass ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Ige Mediated ◽  
Cow’S Milk Protein ◽  
Protein Intolerance
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