Unusual Location of Central Nervous System Langerhans Cell Histiocytosis: Case Report

2003 ◽  
Vol 48 (3) ◽  
pp. 213
Author(s):  
E Yup Kim ◽  
Jae Kyu Lee ◽  
Chan Kyo Kim ◽  
Chang Hyun Lee ◽  
Chang Ho Kang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Unusual Location

Langerhans Cell Histiocytosis Involving Central Nervous System: A Case Report

1997 ◽  
Vol 36 (1) ◽  
pp. 29
Author(s):  
Won Jin Moon ◽  
Dong Woo Park ◽  
Seung Ro Lee ◽  
Chang Kok Hahm ◽  
Sung Tae Kim ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
System A

scholarly journals Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098282
Author(s):  
Chih-Yang Lin ◽  
Chia-Che Lee ◽  
Kuan-Wen Wu ◽  
Chang-Tsu Yuan ◽  
Ken-Nan Kuo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Langerhans Cell Histiocytosis ◽  
Paediatric Oncology ◽  
Bone Diseases ◽  
Langerhans Cell ◽  
Oncology Group ◽  
Preventive Chemotherapy ◽  
System Risk ◽  
Risk Patients

The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatric patients, aged 1 and 2 years, who presented with a solitary tibial lesion at time of LCH diagnosis, are reported. One patient progressed to multiple lesions after curettage of the original lesion. Subsequently, both patients received preventive chemotherapy using the Taiwan Paediatric Oncology Group (TPOG) revised protocol for treating low risk patients with LCH, namely, TPOG LCH2002-LR. After receiving this treatment, which included a schedule of prednisolone and vincristine for 6 weeks, followed by prednisolone, vincristine and 6-mercaptopurine for a further 48 weeks, both patients are free from recurrence or progression.

scholarly journals Adult Langerhans cell histiocytosis of the central nervous system

2020 ◽  
Vol 33 (4) ◽  
pp. 603-605
Author(s):  
Walter R. Duarte-Celada ◽  
Smathorn Thakolwiboon ◽  
Luis Brandi ◽  
Christopher Duarte-Celada ◽  
Mirla Avila
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
The Central Nervous System

A case of fixation amnesia in Langerhans cell histiocytosis involving the central nervous system

2020 ◽  
Vol 12 (6) ◽  
pp. 117-123
Author(s):  
L. V. Lukina ◽  
V. A. Mikhailov ◽  
N. I. Ananyeva ◽  
G. E. Mazo ◽  
L. I. Sitnik ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Langerhans Cell Histiocytosis ◽  
Correct Diagnosis ◽  
Brain Lesion ◽  
Clinical Findings ◽  
Langerhans Cell ◽  
Unknown Etiology ◽  
Bone Lesions ◽  
The Central Nervous System

Langerhans cell histiocytosis (LCH) is a rare disease with hitherto unknown etiology and pathogenesis. It is extremely rare for clinicians to encounter histiocytic lesions of the central nervous system (CNS); the proportion of cases of which is only 1–4% of all polysystemic and multifocal bone lesions. The paper describes a clinical case of fixation amnesia in a female patient with focal brain lesions in LCH. It depicts the most characteristic clinical features and presents an algorithm for the diagnosis of histiocytic brain lesion. The results of the experimental psychological examination of the patient are considered in detail and the clinical presentations of fixation amnesia are described. There are neuroimaging data showing the lesions in the hypothalamic-pituitary region and temporal bone, which involve the auditory structures. The clinical findings have led to the conclusion that both the clinical and neuroimaging patterns of histiocytic lesions in the CNS are non-specific, which complicates the diagnostic search in LCH. For correct diagnosis and timely treatment, it is necessary to perform a biopsy of the pathological focus, followed by histological and immunohistochemical examination of the material.

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