AbstractObjectiveThe aim of this study was to investigate the expression of FXYD domain-containing
ion transport regulator 6 (FXYD6) mRNA and protein in hepatitis B virus
(HBV)-related hepatocellular carcinoma (HCC) tissues with cirrhosis, the
corresponding paracancerous tissues and the normal liver tissues, and to explore
the clinical significance of FXYD6 expression in HBV-related HCC with
cirrhosis.MethodsThe FXYD6 mRNA and protein were examined by semi-quantitative reverse
transcription polymerase chain reaction and immunohistochemistry,
respectively.ResultsThe FXYD6 mRNA in HBV-related HCC tissues was significantly higher than that in
the cirrhosis tissues or that in the normal liver tissues. The positive expression
rate of FXYD6 protein was statistically higher in HBV-related HCC tissues than
that in HBV-related cirrhosis or that in normal liver tissues. There was no
significant correlation between the expression of FXYD6 protein and gender, age,
histological differentiation, tumor diameter, tumor number, integrity of tumor
capsule or not and alpha fetoprotein (AFP) concentration in serum, but the protein
expression was associated with microvascular invasion, pathological stage, and
early recurrence after operation within 1 year.ConclusionFXYD6 might be involved in hepatocyte carcinogenesis and tumor progression in
HBV-related HCC with cirrhosis and indicated a poor prognosis.
Preoperative Prediction for Early Recurrence Can Be as Accurate as Postoperative Assessment in Single Hepatocellular Carcinoma Patients
