scholarly journals Early recurrence after radiofrequency ablation for hepatocellular carcinoma: a multicenter retrospective study on definition, patterns and risk factors

2021 ◽  
Vol 38 (1) ◽  
pp. 437-446
Author(s):  
Yi Yang ◽  
Yujing Xin ◽  
Feng Ye ◽  
Ning Liu ◽  
Xinyuan Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Radiofrequency Ablation ◽  
Early Recurrence

scholarly journals Inflammatory indexes in preoperative blood routine to predict early recurrence of hepatocellular carcinoma after curative hepatectomy

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
YiFeng Wu ◽  
ChaoYong Tu ◽  
ChuXiao Shao
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Tumour Size ◽  
Area Under The Curve ◽  
Early Recurrence ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Lymphocyte Ratio ◽  
Inflammatory Index ◽  
Curative Hepatectomy

Abstract Background The inflammation indexes in blood routine play an essential role in evaluating the prognosis of patients with hepatocellular carcinoma, but the effect on early recurrence has not been clarified. The study aimed to investigate the risk factors of early recurrence (within 2 years) and recurrence-free survival after curative hepatectomy and explore the role of inflammatory indexes in predicting early recurrence. Methods The baseline data of 161 patients with hepatocellular carcinoma were analyzed retrospectively. The optimal cut-off value of the inflammatory index was determined according to the Youden index. Its predictive performance was compared by the area under the receiver operating characteristic curve. Logistic and Cox regression analyses were used to determine the risk factors of early recurrence and recurrence-free survival. Results The area under the curve of monocyte to lymphocyte ratio (MLR) for predicting early recurrence was 0.700, which was better than systemic inflammatory response index (SIRI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII). MLR, tumour size, tumour differentiation and BCLC stage are all risk factors for early recurrence and recurrence-free survival of HCC. Combining the above four risk factors to construct a joint index, the area under the curve for predicting early recurrence was 0.829, which was better than single MLR, tumour size, tumour differentiation and BCLC stage. Furthermore, with the increase of risk factors, the recurrence-free survival of patients is worse. Conclusion The combination of MLR and clinical risk factors is helpful for clinicians to identify high-risk patients with early recurrence and carry out active postoperative adjuvant therapy to improve the prognosis of patients.

scholarly journals Risk factors for very early recurrence of hepatocellular carcinoma: a retrospective review

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S83-S84
Author(s):  
R. Simon ◽  
K. Sasaki ◽  
Georgios A. Margonis ◽  
Jin He ◽  
L. Acevedo-Moreno ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Retrospective Review ◽  
Early Recurrence

A 2-year retrospective study of viral and host-associated risk factors in Pakistani hepatocellular carcinoma patients

2019 ◽  
Vol 31 (9) ◽  
pp. 1103-1109 ◽  
Author(s):  
Zain Ul Abideen ◽  
Shafiqa Siddique ◽  
Izza Nasrullah ◽  
Jahangir S. Khan ◽  
Sidra Rehman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Associated Risk Factors

Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors

2012 ◽  
Vol 23 (1) ◽  
pp. 190-197 ◽  
Author(s):  
Hee Young Lee ◽  
Hyunchul Rhim ◽  
Min Woo Lee ◽  
Young-sun Kim ◽  
Dongil Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Percutaneous Radiofrequency Ablation ◽  
Diffuse Recurrence

scholarly journals Aggressive Intrasegmental Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation: Risk Factors and Clinical Significance

Radiology ◽  
2015 ◽  
Vol 276 (1) ◽  
pp. 274-285 ◽  
Author(s):  
Tae Wook Kang ◽  
Hyo Keun Lim ◽  
Min Woo Lee ◽  
Young-sun Kim ◽  
Hyunchul Rhim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Clinical Significance

Risk Factors for Early Recurrence of Single Lesion Hepatocellular Carcinoma After Curative Resection

2016 ◽  
Vol 40 (10) ◽  
pp. 2466-2471 ◽  
Author(s):  
Mitsugi Shimoda ◽  
Kazuma Tago ◽  
Takayuki Shiraki ◽  
Shozo Mori ◽  
Masato Kato ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Early Recurrence ◽  
Single Lesion

scholarly journals Distant Survival for Patients Undergoing Surgery Using Volatile versus IV Anesthesia for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Retrospective study

2019 ◽  
Author(s):  
Xiao-Yan Meng ◽  
Xiu-Ping Zhang ◽  
Hong-Qian Wang ◽  
Weifeng Yu
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Regression Analysis ◽  
Retrospective Study ◽  
Survival Rate ◽  
Portal Vein ◽  
Subgroup Analysis ◽  
Tumor Thrombus ◽  
Portal Vein Tumor Thrombus ◽  
Cox Regression Analysis

Abstract Background Hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) have lower postoperative survival rate, and anesthesia type may have an effect on tumor recurrence and metastasis.Methods A retrospective study was conducted in Eastern Hepatobiliary Surgery Hospital, Shanghai, China, from January 1, 2008 to December 24, 2012. A total of 1513 HCC patients with PVTT were delivered in the study period. Patients receiving the volatile inhalational anesthesia (INHA) and total IV (TIVA) anesthesia were screen out for comparison. The primary outcome was 5-year overall survival (OS), and secondary outcomes included recurrence-free survival (RFS), postoperative adverse events and liver function. Cox regression analysis was applied to balance confounding variables and estimate risk factors for mortality. Then subgroup analysis of anesthesia type on potential risk factors which were acquired in the final multivariable model were performed.Results After exclusions are applied, 263 patients remain in the INHA group and 208 in the TIVA group. Patients receiving INHA anesthesia have a lower 5-year survival rate than that of patients receiving TIVA anesthesia [12.6% (95% CI, 9.0 to 17.3) vs. 17.7% (95% CI, 11.3 to 20.8), P=0.024]. Results from multivariable regression analysis also identify that INHA anesthesia is significantly associated with the OS ang RFS compared with TIVA anesthesia, with HR (95%CI) of 1.303 (1.065, 1.595) and 1.265 (1.040, 1.539), respectively. Subgroup analysis suggested that in more severe cancer patients, the worse outcome related to INHA might be more significant.Conclusion This retrospective analysis identifies that patients receiving TIVA have better survival rate compare to receiving INHA in HCC patients with PVTT. Future prospective researches are urgent to verify this difference and figure out underlying causes of it.

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