scholarly journals Epstein–Barr Virus-Induced Acute Hepatitis, Pancreatitis, and Pneumonitis in a Young Immunocompetent Adult: A Case Report

2021 ◽  
Author(s):  
Elias Fiani ◽  
Rafca Challita ◽  
Hanaa Badawaki ◽  
Khaled Soukarieh ◽  
Melissa Kyriakos Saad ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Rare Complication ◽  
Human Herpesvirus ◽  
B Cell Lymphoma ◽  
Herpesvirus Type ◽  
Barr Virus ◽  
Ebv Infection ◽  
Human Herpesvirus Type ◽  
Epstein Barr

Epstein–Barr virus (EBV) is a common herpes virus (human herpesvirus type 4) that usually manifests as infectious mononucleosis or persists asymptomatically for life. EBV can also be associated with different types of malignancy such as T cell lymphoma, B cell lymphoma, Hodgkin lymphoma, and oropharyngeal squamous cell and nasopharyngeal carcinoma. Pneumonia is a very rare complication of EBV infection, but it has been reported to occur even in the absence of mononucleosis. This article highlights the case of 35-year-old female who developed acute pancreatitis and acute respiratory failure related to EBV infection. The patient progressively recovered on antiviral therapy and steroids.

scholarly journals Epstein-Barr virus associated with high-grade B-cell lymphoma in nude severe combined immunodeficiency

2019 ◽  
Vol 12 (5) ◽  
pp. e227715 ◽  
Author(s):  
Rawia Albar ◽  
Moaffaq Mahdi ◽  
Fawaz Alkeraithe ◽  
Khalid Nawaf Almufarriji
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Severe Combined Immunodeficiency ◽  
B Cell Lymphoma ◽  
High Grade ◽  
Combined Immunodeficiency ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr

Severe combined immunodeficiency (SCID) is an extremely rare disease caused by a disruption in the forkhead box N1 (FOXN1) gene, with an incidence of <1 per 1 000 000 live births. We report a boy aged 4 months who presented with a history of fever for 3 weeks and enlarged lymph nodes. The fever was associated with dry cough and runny nose. On physical examination, we noted oral thrush, generalised lymphadenopathy, nail dystrophy and alopecia. Flow cytometry of lymph node biopsy showed high-grade B-cell lymphoma. In addition, Epstein-Barr virus (EBV) infection was documented by PCR. The diagnosis of SCID was made by genetic testing, which revealed a homozygous variant of the FOXN1 gene. The variant was confirmed with Sanger sequencing. Management of EBV infection and lymphoma was initiated; unfortunately, the patient passed away on day 45 of hospitalisation.

scholarly journals Infectious mononucleosis mimicking Epstein–Barr virus positive diffuse large B-cell lymphoma not otherwise specified

2020 ◽  
Vol 9 (2) ◽  
pp. IJH25
Author(s):  
Tejaswi Kanderi ◽  
Maged S Khoory
Keyword(s):  
B Cell ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Large B Cell Lymphoma ◽  
Epstein Barr ◽  
Large B Cell

The Epstein–Barr virus (EBV) causes infectious mononucleosis (IM). In the case of atypical presentation, lymph node and tonsillar biopsies are required to rule out lymphoma. Here, we discuss an 83-year-old male who presented with findings suggestive of diffuse large B-cell lymphoma, which was later ruled out in favor of IM. The distinction between IM and lymphomas is quite challenging due to the extensive overlap between the two diseases. Various studies have demonstrated that EBV-positive diffuse large B-cell lymphoma mimics IM due to large B-cell proliferation in acute EBV infection. We suggest testing for acute EBV infection in addition to utilizing advanced testing to confirm IM in patients with atypical infection, to avoid misdiagnosis leading to inappropriate treatment.

scholarly journals A case of abdominal-pelvic infiltrative lesion of chronic active Epstein–Barr virus infection

2020 ◽  
Vol 18 ◽  
pp. 205873922093688
Author(s):  
Tianjiao Xue ◽  
Huan Ye ◽  
Fang Li ◽  
Chengyu Luo ◽  
Shumei Liu ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Human Herpesvirus ◽  
Epstein Barr Virus Infection ◽  
Herpesvirus Type ◽  
Barr Virus ◽  
Human Herpesvirus Type ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein–Barr virus (EBV) belongs to a subfamily of herpesviruses, also known as human herpesvirus type 4. EBV is widely distributed in the population, with a high infection rate of 90%. EBV infects mainly B lymphocytes, stimulates cell proliferation and transformation and even causes cancer. In recent years, it has been found that it can also infect T lymphocytes, epithelial cells and natural killer (NK) cells and can cause related diseases. EBV infection can cause a variety of clinical symptoms and clinical manifestations, which brings some confusion to clinical diagnosis and easily leads to missed diagnosis and misdiagnosis. In this article, we report a case of EBV-induced severe abdominal and pelvic infection, which eventually led to death.

scholarly journals Induction of Lytic Epstein-Barr Virus (EBV) Infection by Synergistic Action of Rituximab and Dexamethasone Renders EBV-Positive Lymphoma Cells More Susceptible to Ganciclovir Cytotoxicity In Vitro and In Vivo

2005 ◽  
Vol 79 (9) ◽  
pp. 5875-5879 ◽  
Author(s):  
Masanori Daibata ◽  
Kentaro Bandobashi ◽  
Masayuki Kuroda ◽  
Shosuke Imai ◽  
Isao Miyoshi ◽  
...  
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr

ABSTRACT The purposeful induction of the lytic form of Epstein-Barr virus (EBV) infection combined with ganciclovir (GCV) treatment has been advocated as a novel strategy for EBV-positive B-cell lymphoma. We demonstrated that rituximab had a synergistic effect with dexamethasone on induction of the lytic EBV infection in CD20-positive lymphoma cells. Addition of GCV to the dexamethasone/rituximab-treated cells was more effective than dexamethasone/rituximab alone in killing EBV-positive lymphoma cells in vitro and in lymphoma-bearing nude mice but not in EBV-negative cells. These data suggest that induction of the lytic EBV infection with dexamethasone/rituximab in combination with GCV could be a potential virally targeted therapy for EBV-associated B-cell lymphoma.

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