Beyond the simple contrastive analysis: Appropriate experimental approaches for unraveling the neural basis of conscious experience

2015 ◽  
2021 ◽  
pp. 209660832110064
Author(s):  
Duoyi Fei

By means of spontaneous and unconscious imitation, an observer may be able to directly experience the inner states of another person because the observer and the observed share similar neural pathways. This discovery of a common neural basis reveals the correlative mechanisms through which the intentions of others are perceived. While analysing the implications of this discovery, this paper notes that the correlation does not provide a complete explanation of our understanding of other minds. Instead, the correlation comes into play only to a minimal degree. The paper also explores the epistemological characteristic of the knowledge harboured by other minds. That is, as a kind of private knowledge, the experience of other minds can help us arrive at a relatively consistent understanding of others and engage in communication with them through public expression and the description of mental states. However, it is impossible to truly understand other minds because conscious experience in the strict sense resides only in its owner, and the unique qualia emerging inside the subject cannot be directly observed from a third-person perspective. In this sense, the so-called perception of other minds is not suited to seeking a causal explanation of the ways in which others act, but for reading the meanings expressed by them in a given situation.


2015 ◽  
Vol 29 (4) ◽  
pp. 135-146 ◽  
Author(s):  
Miroslaw Wyczesany ◽  
Szczepan J. Grzybowski ◽  
Jan Kaiser

Abstract. In the study, the neural basis of emotional reactivity was investigated. Reactivity was operationalized as the impact of emotional pictures on the self-reported ongoing affective state. It was used to divide the subjects into high- and low-responders groups. Independent sources of brain activity were identified, localized with the DIPFIT method, and clustered across subjects to analyse the visual evoked potentials to affective pictures. Four of the identified clusters revealed effects of reactivity. The earliest two started about 120 ms from the stimulus onset and were located in the occipital lobe and the right temporoparietal junction. Another two with a latency of 200 ms were found in the orbitofrontal and the right dorsolateral cortices. Additionally, differences in pre-stimulus alpha level over the visual cortex were observed between the groups. The attentional modulation of perceptual processes is proposed as an early source of emotional reactivity, which forms an automatic mechanism of affective control. The role of top-down processes in affective appraisal and, finally, the experience of ongoing emotional states is also discussed.


2014 ◽  
Vol 222 (3) ◽  
pp. 148-153 ◽  
Author(s):  
Sabine Vits ◽  
Manfred Schedlowski

Associative learning processes are one of the major neuropsychological mechanisms steering the placebo response in different physiological systems and end organ functions. Learned placebo effects on immune functions are based on the bidirectional communication between the central nervous system (CNS) and the peripheral immune system. Based on this “hardware,” experimental evidence in animals and humans showed that humoral and cellular immune functions can be affected by behavioral conditioning processes. We will first highlight and summarize data documenting the variety of experimental approaches conditioning protocols employed, affecting different immunological functions by associative learning. Taking a well-established paradigm employing a conditioned taste aversion model in rats with the immunosuppressive drug cyclosporine A (CsA) as an unconditioned stimulus (US) as an example, we will then summarize the efferent and afferent communication pathways as well as central processes activated during a learned immunosuppression. In addition, the potential clinical relevance of learned placebo effects on the outcome of immune-related diseases has been demonstrated in a number of different clinical conditions in rodents. More importantly, the learned immunosuppression is not restricted to experimental animals but can be also induced in humans. These data so far show that (i) behavioral conditioned immunosuppression is not limited to a single event but can be reproduced over time, (ii) immunosuppression cannot be induced by mere expectation, (iii) psychological and biological variables can be identified as predictors for this learned immunosuppression. Together with experimental approaches employing a placebo-controlled dose reduction these data provide a basis for new therapeutic approaches to the treatment of diseases where a suppression of immune functions is required via modulation of nervous system-immune system communication by learned placebo effects.


2001 ◽  
Vol 46 (5) ◽  
pp. 462-464
Author(s):  
Roberto Cabeza
Keyword(s):  

1990 ◽  
Vol 35 (8) ◽  
pp. 779-779
Author(s):  
Jeri S. Janowsky

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