scholarly journals Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates

2020 ◽  
Vol 8 ◽  
Author(s):  
Javier Acosta ◽  
Jon Del Arco ◽  
Maria Luisa Del Pozo ◽  
Beliña Herrera-Tapias ◽  
Vicente Javier Clemente-Suárez ◽  
...  
Keyword(s):  
Adenylate Kinase ◽  
Bifunctional Catalyst ◽  
Hypoxanthine Guanine Phosphoribosyltransferase

An integrated approach for thermal stabilization of a mesophilic adenylate kinase

2014 ◽  
Vol 82 (9) ◽  
pp. 1947-1959 ◽  
Author(s):  
Sojin Moon ◽  
Du-kyo Jung ◽  
George N. Phillips ◽  
Euiyoung Bae
Keyword(s):  
Adenylate Kinase ◽  
Thermal Stabilization ◽  
Integrated Approach

P1, P5-Bis-(5′-adenosyl)pentaphosphate: Is this Adenylate Kinase Inhibitor Substrate for Mitochondrial Processes?

1977 ◽  
Vol 32 (9-10) ◽  
pp. 786-791 ◽  
Author(s):  
Josef Köhrle ◽  
Joachim Lüstorff ◽  
Eckhard Schlimme
Keyword(s):  
Adenylate Kinase ◽  
Kinase Inhibitor ◽  
Adenine Nucleotide ◽  
Nucleoside Diphosphate Kinase ◽  
Liver Mitochondria ◽  
Inhibitory Effect ◽  
Rat Liver Mitochondria ◽  
Intermembrane Space ◽  
Rabbit Muscle ◽  
Inner Mitochondrial Membrane

Abstract 1. P1, P5-Bis-(5′-adenosyl)pentaphosphate (Ap5A) inhibits “soluble” adenylate kinase even when this enzyme is an integral part of the complete mitochondrion. The Ki is 10-5м , i. e. about two orders of magnitude higher than the inhibitor constants determined for the purified adenylate kinase of rabbit muscle and an enzyme preparation separated from the mitochondrial intermembrane space. The weaker inhibitory effect is due to a lower accessibility of the enzyme.2. As to be expected Ap5A which is of the “multisubstrate analogue”-type does not affect mito­ chondrial nucleoside diphosphate kinase.3. Though Ap5A owns the structural elements of both ATP and ADP it is not a substrate of the adenine nucleotide carrier, i.e. neither it is exchanged across the inner mitochondrial membrane nor specifically bound.4. Ap5A is not metabolized by rat liver mitochondria.

Highly efficient metal-free electro-Fenton degradation of organic contaminants on a bifunctional catalyst

2021 ◽  
Vol 416 ◽  
pp. 125859
Author(s):  
Xin Qin ◽  
Kun Zhao ◽  
Xie Quan ◽  
Peike Cao ◽  
Shuo Chen ◽  
...  
Keyword(s):  
Organic Contaminants ◽  
Bifunctional Catalyst ◽  
Metal Free ◽  
Highly Efficient
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