Obesity Exacerbates Irritable Bowel Syndrome-Related Sleep and Psychiatric Disorders in Women With Polycystic Ovary Syndrome

Background/ObjectivesPolycystic ovary syndrome (PCOS) and irritable bowel syndrome (IBS) share similar clinical and psychosocial features. We aimed to investigate the clinical characteristics of IBS in women with PCOS, and its relationship with obesity, metabolic and hormonal profiles, as well as sleep and psychiatric disorders.Subjects/MethodsThis is a cross-sectional case-control study of 431 untreated women with PCOS and 259 healthy volunteers. All participants were assessed with a comprehensive clinical evaluation and two questionnaires: the Athens Insomnia Scale (AIS) and the Brief Symptom Rating Scale (BSRS-5). IBS was diagnosed using the Rome III criteria. Obesity was defined as a BMI ≥30 kg/m2. Anthropometric measurements, metabolic, hormonal profiles, and psychosocial morbidities were compared.ResultsWomen with PCOS were more likely to have IBS (10.7% vs 5.8%, p=0.029) and obesity (29% vs 4%, p<0.001) than healthy volunteers. Mixed-type IBS (IBS-M) was the most common subtype (74%) among patients with PCOS and IBS. There was a higher prevalence of psychiatric morbidities (total BSRS-5 score ≥10) in women with PCOS than in healthy women (11.4% vs 3.5%, p<0.001). Women with PCOS and IBS were more likely to have sleep difficulties (67.4% vs 30.9%, p<0.001) and psychiatric morbidities (21.7% vs 10.1%, p=0.019) than those without IBS. Anthropometrics, metabolic and hormonal profiles were similar between PCOS women with and without IBS. Among women with PCOS, those with both IBS and obesity had the highest risk of developing sleep difficulties (odds ratio: 5.91; 95% confidence interval: 1.77–19.77) and psychiatric distress (odds ratio: 4.39; 95% confidence interval: 1.26–15.29) than those without.ConclusionWomen with PCOS have increased IBS, obesity, sleep and psychiatric disturbances. The presence of IBS in PCOS women is associated with sleep and psychiatric disorders. The coexistence of obesity and IBS exacerbates sleep difficulties and psychiatric distress. Screening and management of IBS and obesity might be warranted to improve sleep and psychiatric disturbances in women with PCOS.

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Polycystic Ovary Syndrome Is Associated with an Increased Prevalence of Irritable Bowel Syndrome

Digestive Diseases and Sciences ◽

10.1007/s10620-009-0890-5 ◽

2009 ◽

Vol 55 (4) ◽

pp. 1085-1089 ◽

Cited By ~ 12

Author(s):

Ruchi Mathur ◽

Ara Ko ◽

Laura J. Hwang ◽

Kimberly Low ◽

Ricardo Azziz ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Irritable Bowel

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Incidences of irritable bowel syndrome and its subtypes in patients with polycystic ovary syndrome

Journal of Clinical and Analytical Medicine ◽

10.4328/jcam.5755 ◽

2018 ◽

Vol 9 (4) ◽

Author(s):

Huseyin Dursun

Keyword(s):

Irritable Bowel Syndrome ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Irritable Bowel

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Irritable bowel syndrome, endometriosis and polycystic ovary syndrome: is there a link?

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20192532 ◽

2019 ◽

Vol 7 (6) ◽

pp. 2449

Author(s):

Ashwath Narayan Ramji

Keyword(s):

Irritable Bowel Syndrome ◽

Polycystic Ovary Syndrome ◽

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Polycystic Ovary ◽

Difficult Problem ◽

General Surgeon ◽

Common Denominator ◽

Ovary Syndrome ◽

Irritable Bowel

Chronic pelvic pain is a common yet difficult problem to manage, plaguing the gynecologist as well as the gastroenterologist and general surgeon. Highlighted by increased visceral hypersensitivity, endometriosis and irritable bowel syndrome (IBS) are the most common causes or chronic unrelenting pelvic pain. Recently, the similarities between the two conditions has begged the question as to whether there is any common denominator between the two conditions and their likely co-existence and mismanagement. Further, the association of polycystic ovary syndrome (PCOS) in this cohort remains definitively uncharacterized. This report details a young female patient with the triad of POCS, IBS and endometriosis presenting with chronic pelvic pain.

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Rome IV Diagnostic Criteria for Irritable Bowel Syndrome in polycystic ovary syndrome patients

Liječnički vjesnik ◽

10.26800/lv-142-supp5-35 ◽

2021 ◽

Vol 142 (Supp 5) ◽

Keyword(s):

Irritable Bowel Syndrome ◽

Polycystic Ovary Syndrome ◽

Diagnostic Criteria ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Irritable Bowel ◽

Rome Iv

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The impact of irritable bowel syndrome on health-related quality of life in women with polycystic ovary syndrome

10.21203/rs.2.17261/v1 ◽

2019 ◽

Author(s):

Seyed Abdolvahab Taghavi ◽

Zatollah Asemi ◽

Fatemeh Bazarganipour ◽

Helen Allan ◽

Zahra Khashavi ◽

...

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Control Group ◽

Ovary Syndrome ◽

Food Avoidance ◽

Irritable Bowel ◽

The Impact

Abstract The objectives of this study were to compare the prevalence and quality of life (QOL) of irritable bowel syndrome (IBS) in women with polycystic ovary syndrome (PCOS) compared with healthy women.Methods This was a case-control study of 201 women recruited at an infertility clinic in Iran. The control group were healthy women (n=100) and the comparison group, women with PCOS (n=101). Data were collected by clinical Rome III criteria to determine the IBS, Bristol scale for stool consistency and IBS QOL.Results The reporting of IBS symptoms was higher in PCOS (20.7%) than control group (11%) (P=0.05). Predictive factors of IBS included having diagnosed PCOS (OR: 1.61; CI: 0.71–2.11) and an increase of LH/FSH (OR: 1.09; 0.95 CI: (0.83-1.45). The IBS QOL score in the IBS+PCOS group was lower than other groups (IBS+ non PCOS, non IBS+PCOS, non IBS+ non PCOS; scores in food avoidance and worries about health domains were significant (P<0.01). Conclusions: We conclude that having PCOS and an increased level of LH/FSH tends to cause IBS symptoms. IBS+PCOS women experience significant impaired quality of life scores particularly in relation to worries about health and food avoidance. These results offer further insights into IBS in PCOS women and their functional status and wellbeing.

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