scholarly journals A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4+ and CD8+ T Cells

2017 ◽  
Vol 8 ◽  
Author(s):  
Angello R. Retamal-Díaz ◽  
Alexis M. Kalergis ◽  
Susan M. Bueno ◽  
Pablo A. González
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Cd8 T Cells ◽  
Herpes Simplex Virus Type ◽  
Glycoprotein D ◽  
Simplex Virus

scholarly journals Vaccination by cholera toxin conjugated to a herpes simplex virus type 2 glycoprotein D peptide

1992 ◽  
Vol 73 (9) ◽  
pp. 2357-2366 ◽  
Author(s):  
M. D. Drew ◽  
A. Estrada-Correa ◽  
B. J. Underdown ◽  
M. R. McDermott
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cholera Toxin ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Glycoprotein D ◽  
Simplex Virus

scholarly journals Caspase 9 Is Essential for Herpes Simplex Virus Type 2-Induced Apoptosis in T Cells

2010 ◽  
Vol 84 (6) ◽  
pp. 3116-3120 ◽  
Author(s):  
Michael J. Vanden Oever ◽  
Jin-Young Han
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Intrinsic Pathway ◽  
Caspase 9 ◽  
Induced Apoptosis ◽  
Simplex Virus

ABSTRACT Herpes simplex virus type 2 (HSV-2) induces apoptosis in T cells by a caspase-dependent mechanism. Apoptosis can occur via extrinsic (death receptor) and/or intrinsic (mitochondrial) pathways. Here, we show that the initiator caspase for the intrinsic pathway is activated in T cells following HSV-2 exposure. To determine the respective contributions of intrinsic and extrinsic pathways, we assessed apoptosis in Jurkat cells that are deficient in caspase 8 or Fas-associating protein with death domain (FADD) for the extrinsic pathway and in cells deficient in caspase 9 for the intrinsic pathway. Our results indicate HSV-2-induced apoptosis in T cells occurs via the intrinsic pathway.

scholarly journals Latency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cells

2010 ◽  
Vol 82 (11) ◽  
pp. 1917-1920 ◽  
Author(s):  
Viktor Arbusow ◽  
Tobias Derfuss ◽  
Kathrin Held ◽  
Susanne Himmelein ◽  
Michael Strupp ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Cd8 T Cells ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

Baculovirus-expressed herpes simplex virus type 2 glycoprotein D is immunogenic and protective against lethal HSV challenge

Vaccine ◽  
1993 ◽  
Vol 11 (4) ◽  
pp. 407-414 ◽  
Author(s):  
V. Landolfi ◽  
C.D. Zarley ◽  
A.S. Abramovitz ◽  
N. Figueroa ◽  
S.L. Wu ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Glycoprotein D ◽  
Simplex Virus
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