Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report

Acute Lantana camara poisoning in a Boer goat kid is described. The animal was part of a flock of boer goats that was introduced from the Kalahari thornveld, where the plant does not occur, to an area where the plant grew abundantly. At necropsy, the animal was severely icteric, dehydrated and constipated, with hepatosis, distention of the gall-bladder and nephrosis, but no skin lesions. Histopathological findings of the liver confirmed moderate hepatosis with single-cell necrosis and bile stasis. The pathology is consistent with that described in acute Lantana poisoning in cattle, sheep and goats. The absence of photosensitisation may be attributed to relatively mild liver damage, or the rapid course of this toxicosis.

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Epileptic Seizure Provoked by Bone Metastasis of Chronic Lymphoid Leukemia and Merkel Cell Carcinoma – Case Report

10.21203/rs.2.358/v1 ◽

2019 ◽

Author(s):

András Folyovich ◽

Angéla Majoros ◽

Tamás Jarecsny ◽

Gitta Pánczél ◽

Zsuzsanna Pápai ◽

...

Keyword(s):

Bone Metastases ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Cerebral Metastasis ◽

Merkel Cell ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia ◽

History Of ◽

The Right ◽

The Brain

Abstract Background Merkel cell carcinoma (MCC) is a rare primary neuroendocrine cutaneous tumor, rarely metastatizing to the brain. Chronic lymphoid leukemia (CLL) is a disease predisposing to MCC. According to previous reports, headache and focal neurological deficits suggest disease progression to the brain. We present a patient with MCC whose seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. Case presentation The 62-year-old female patient had a history of CLL. A lesion with the appearance of an atheroma was removed from the right upper arm. Histology confirmed the diagnosis of MCC. She was admitted to the neurology department with her first GM seizure. The cranial MRI/MRA showed bone metastases in the right parietal and left frontal areas, compressing the brain. Flow cytometry of CSF did not reveal metastasis of MCC or CLL. No surgery was performed, chemotherapy was continued. Conclusions The case history of the patient was unique even among the rare cases of MCC with neurological involvement. The seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. In addition to patient history, clinical presentation and radiological findings enabled a suspected diagnosis preceding confirmation by laboratory methods.

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Major rise of a chronic lymphoid leukemia clone during the course of COVID‐19

International Journal of Laboratory Hematology ◽

10.1111/ijlh.13383 ◽

2020 ◽

Author(s):

Laetitia Largeaud ◽

Agnès Ribes ◽

Frédérique Dubois‐Galopin ◽

Vincent Mémier ◽

Yves Rolland ◽

...

Keyword(s):

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia

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Epileptic Seizure Provoked by Bone Metastasis of Chronic Lymphoid Leukemia and Merkel Cell Carcinoma

Case Reports in Medicine ◽

10.1155/2020/4318638 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

András Folyovich ◽

Angéla Majoros ◽

Tamás Jarecsny ◽

Gitta Pánczél ◽

Zsuzsanna Pápai ◽

...

Keyword(s):

Bone Metastases ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Cerebral Metastasis ◽

Merkel Cell ◽

Lymphoid Leukemia ◽

Chronic Lymphoid Leukemia ◽

History Of ◽

The Right ◽

The Brain

Background. Merkel cell carcinoma (MCC) is a rare primary neuroendocrine cutaneous tumor, rarely metastasizing to the brain. Chronic lymphoid leukemia (CLL) is a disease predisposing to MCC. According to previous reports, headache and focal neurological deficits suggest disease progression to the brain. We present a patient with MCC whose seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. Case Presentation. A 62-year-old female patient had a history of CLL. A lesion with the appearance of an atheroma was removed from the right upper arm. Histology confirmed the diagnosis of MCC. She was admitted to the neurology department with her first GM seizure. The cranial MRI/MRA showed bone metastases in the right parietal and both frontal areas, compressing the brain. Flow cytometry of CSF did not reveal metastasis of MCC. Conclusions. The case history of the patient was unique even among the rare cases of MCC with neurological involvement. The seizure was not elicited by a cerebral metastasis, but by bone metastases compressing the brain. In addition to patient history, clinical presentation and radiological findings enabled a suspected diagnosis of skull metastasis of MCC compressing the brain, causing symptomatic epileptic seizures.

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