scholarly journals Case Report: Primary Peritonitis as the Onset of Pediatric Ménétrier's Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Ana Barrés-Fernández ◽  
Andrés Piolatti-Luna ◽  
José Rafael Bretón-Martínez ◽  
Elena Crehuá-Gaudiza ◽  
Carmen Quiñones-Torrelo ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Acute Phase Reactants ◽  
Protein Losing Enteropathy ◽  
Menetrier’S Disease ◽  
Primary Peritonitis ◽  
Benign Nature ◽  
Alpha 1 Antitrypsin ◽  
Ménétrier's Disease ◽  
Stool Analysis ◽  
Menetrier's Disease

Introduction: Primary peritonitis (PP) and Ménétrier's Disease (MD) are both rare conditions among pediatric population. Although about 150 MD cases have been described in the scientific literature to date, its onset with a PP is an unusual condition.Case Presentation: We present a case of an 11-year-old boy who was admitted to our unit because of abdominal pain and distension. Complementary tests showed ascites, bilateral pleural effusion, leukocytosis, increased acute phase reactants and hypoproteinemia with hypoalbuminemia. Laparoscopy ruled out appendicitis or visceral perforations and exposed purulent peritoneal fluid, compatible with PP. Biochemical stool analysis showed increased clearance of alpha-1-antitrypsin, which was consistent with a protein-losing enteropathy. Gastroscopy findings were compatible with MD. The clinical course was favorable and he had no recurrence after 12 months of follow-up.Conclusion: PP can be the first clinical manifestation of pediatric MD. Knowledge of MD and its generally benign nature in children is important in order to avoid excessive testing and unnecessary treatment.

scholarly journals Atypical Clinical and Diagnostic Features in Ménétrier's Disease in a Child

2011 ◽  
Vol 2011 ◽  
pp. 1-5
Author(s):  
Michael Chung ◽  
Jaime Pittenger ◽  
Deborah Flomenhoft ◽  
Jeffrey Bennett ◽  
Eun-Young Lee ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Oral Intake ◽  
Acute Onset ◽  
School Age Children ◽  
Viral Gastroenteritis ◽  
Diagnostic Features ◽  
Protein Losing Enteropathy ◽  
Menetrier’S Disease ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

Ménétrier's disease is one of the rarest protein-losing gastropathies in childhood. It is characterized clinically by non-specific gastrointestinal symptoms and edema, biochemically by hypoalbuminemia, and pathologically by enlarged gastric folds. In adults, this disease can be devastating with significant morbidity and mortality. In childhood, it is a self-limiting, transient and benign illness. Its treatment is largely supportive with total parenteral nutrition (TPN) while oral intake is encouraged. Acute onset of vomiting in healthy school age children can be initially explained by acute viral gastroenteritis. However, persistent vomiting associated with hematemesis and severe abdominal pain should warrant further work-up. This case report illustrates a self-limiting and rare cause of protein-losing enteropathy called Ménétrier's disease that presented with several variant clinical features not typically described in association with this entity.

Comparison of Gastrointestinal Loss of Alpha-1-Antitrypsin and Chromium-51-Albumin in Ménétrier’s Disease and the Influence of Ranitidine

Digestion ◽  
1983 ◽  
Vol 26 (4) ◽  
pp. 192-196 ◽  
Author(s):  
W.H. Reinhart ◽  
K. Weigand ◽  
M. Kappeler ◽  
H. Roesler ◽  
F. Halter
Keyword(s):  
Menetrier’S Disease ◽  
Alpha 1 Antitrypsin ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

Protein-losing Enteropathy Including Intestinal Lymphangiectasia and Ménétrier’s Disease

1988 ◽  
pp. 163-183
Author(s):  
Hitoshi Asakura ◽  
Akira Morita ◽  
Soichiro Miura ◽  
Masaharu Tsuchiya ◽  
Yasuyoshi Enomoto ◽  
...  
Keyword(s):  
Intestinal Lymphangiectasia ◽  
Protein Losing Enteropathy ◽  
Menetrier’S Disease ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

scholarly journals A Rare case of Menetrier’s disease presenting with Protein Losing Gastropathy Mimicking Carcinoma Stomach

2021 ◽  
Vol 5 (4) ◽  
pp. 01-03
Author(s):  
Richmond Ronald Gomes
Keyword(s):  
Protein Losing Enteropathy ◽  
Hypertrophic Gastritis ◽  
Menetrier’S Disease ◽  
Increased Risk ◽  
History Of ◽  
Gastric Corpus ◽  
Carcinoma Stomach ◽  
Ménétrier's Disease ◽  
Mucosal Folds ◽  
Menetrier's Disease

Ménétrier's disease (MD) (also known as giant hypertrophic gastritis or hypoproteinemic hypertrophic gastropathy) is a rare premalignant entity characterized by markedly hypertrophied mucosal folds of the fundus and the gastric corpus typically associated with , hypochlorhydria, protein losing enteropathy causing hypoalbuminemia and anemia. However, the natural history of MD in adults remains unclear and is rarely reported in the literature. Its constellation of classic symptoms includes nausea, vomiting, abdominal pain and peripheral edema, and it is associated with increased risk of gastric cancer. Nevertheless, its pathophysiology is not yet fully understood and clinical and endoscopic diagnosis can be difficult to establish. Malignant transformation in MD should not be overlooked, and regular monitoring of the gastric mucosa via endoscopy is necessary.

Pernicious Anemia Following Total Gastrectomy for Giant Hypertrophy of the Gastric Rugae (Menetrier’s Disease)

1960 ◽  
Vol 39 (3) ◽  
pp. 347-350 ◽  
Author(s):  
Earl E. Gambill ◽  
Donald C. Campbell ◽  
Donald C. Balfour ◽  
John M. Waugh ◽  
Malcolm B. Dockerty
Keyword(s):  
Pernicious Anemia ◽  
Total Gastrectomy ◽  
Menetrier’S Disease ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

CLINICAL AND MORPHOLOGICAL STUDIES OF GIANT HYPERTROPHIC GASTRITIS (MÉNÉTRIER'S DISEASE)

2009 ◽  
Vol 195 (1-6) ◽  
pp. 247-252 ◽  
Author(s):  
Heino Raotma ◽  
Lennart Angervall ◽  
Ingvar Dahl ◽  
Gerhard Dotevall
Keyword(s):  
Hypertrophic Gastritis ◽  
Menetrier’S Disease ◽  
Morphological Studies ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

Ménétrier’s disease in a patient with refractory ulcerative colitis: a clinical challenge and review of the literature

2021 ◽  
Vol 14 (10) ◽  
pp. e246137
Author(s):  
Sofia Rao ◽  
Anna Viola ◽  
Omar Ksissa ◽  
Walter Fries
Keyword(s):  
Ulcerative Colitis ◽  
Rare Disease ◽  
Treatment Options ◽  
Review Of The Literature ◽  
Protein Loss ◽  
Menetrier’S Disease ◽  
Clinical Challenge ◽  
Endoscopic Remission ◽  
Ménétrier's Disease ◽  
Menetrier's Disease

Ménétrier’s disease (MD) is a rare disease of the stomach, characterised by hypertrophic gastric folds leading to protein loss. The association with ulcerative colitis (UC) is rare but has been reported in the literature. We report a case of a 29-year-old male affected by UC with an additional diagnosis of MD 3 years after UC diagnosis. UC was refractory to several treatment lines (thiopurines, infliximab, vedolizumab and ustekinumab), and the patient underwent colectomy. Octreotide was administered for MD normalising blood biochemistry, but it was not effective in inducing endoscopic remission of the stomach. Treatment options in patients with MD and UC are discussed.

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