scholarly journals Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering

2019 ◽  
Vol 10 ◽  
Author(s):  
Xin Zhang ◽  
Xingnan Lin ◽  
Tie Liu ◽  
Liquan Deng ◽  
Yuanliang Huang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Morphogenetic Protein ◽  
Bone Tissue ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein

Bone Morphogenetic Protein-2 Plasmid DNA as a Substitute for Bone Morphogenetic Protein-2 Protein in Bone Tissue Engineering

2013 ◽  
Vol 19 (23-24) ◽  
pp. 2686-2692 ◽  
Author(s):  
Fiona Wegman ◽  
Yvonne van der Helm ◽  
F. Cumhur Öner ◽  
Wouter J.A. Dhert ◽  
Jacqueline Alblas
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Morphogenetic Protein ◽  
Bone Tissue ◽  
Plasmid Dna ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein

scholarly journals A new biocompatible delivery scaffold containing heparin and bone morphogenetic protein 2

2016 ◽  
Vol 66 (3) ◽  
pp. 373-385 ◽  
Author(s):  
Suphannee Thanyaphoo ◽  
Jasadee Kaewsrichan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Morphogenetic Protein ◽  
Bone Tissue ◽  
Bone Morphogenetic Protein 2 ◽  
In Vivo Experiments ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein

Abstract Silicon-substituted calcium phosphate (Si-CaP) was developed in our laboratory as a biomaterial for delivery in bone tissue engineering. It was fabricated as a 3D-construct of scaffolds using chitosan-trisodium polyphosphate (TPP) cross-linked networks. In this study, heparin was covalently bonded to the residual -NH2 groups of chitosan on the scaffold applying carbodiimide chemistry. Bonded heparin was not leached away from scaffold surfaces upon vigorous washing or extended storage. Recombinant human bone morphogenetic protein 2 (rhBMP-2) was bound to conjugated scaffolds by ionic interactions between the negatively charged SO42- clusters of heparin and positively charged amino acids of rhBMP-2. The resulting scaffolds were inspected for bone regenerative capacity by subcutaneous implanting in rats. Histological observation and mineralization assay were performed after 4 weeks of implantation. Results from both in vitro and in vivo experiments suggest the potential of the developed scaffolds for bone tissue engineering applications in the future.

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