scholarly journals Local Injections of Superoxide Dismutase Attenuate the Exercise Pressor Reflex in Rats with Femoral Artery Occlusion

2018 ◽  
Vol 9 ◽  
Author(s):  
Jihong Xing ◽  
Jian Lu ◽  
Jiahao Liu ◽  
Jianhua Li
Keyword(s):  
Superoxide Dismutase ◽  
Femoral Artery ◽  
Artery Occlusion ◽  
Exercise Pressor Reflex ◽  
Femoral Artery Occlusion ◽  
Local Injections ◽  
Pressor Reflex

scholarly journals Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral artery ligated rats

2011 ◽  
Vol 111 (4) ◽  
pp. 971-979 ◽  
Author(s):  
Jennifer L. McCord ◽  
Hirotsugu Tsuchimochi ◽  
Katsuya Yamauchi ◽  
Anna Leal ◽  
Marc P. Kaufman
Keyword(s):  
Reactive Oxygen Species ◽  
Superoxide Dismutase ◽  
Femoral Artery ◽  
Reactive Oxygen ◽  
Artery Occlusion ◽  
Arterial Supply ◽  
Oxygen Species ◽  
Exercise Pressor Reflex ◽  
Femoral Artery Occlusion ◽  
Pressor Reflex

In decerebrate rats, we reported previously that the exercise pressor reflex arising from a limb whose femoral artery was occluded for 72 h before the experiment was significantly higher than the exercise pressor reflex arising from a contralateral freely perfused limb. These findings prompted us to examine whether reactive oxygen species contributed to the augmented pressor reflex in rats with femoral artery occlusion. We found that the pressor reflex arising from the limb whose femoral artery was occluded for 72 h before the experiment (31 ± 5 mmHg) was attenuated by tempol (10 mg), a superoxide dismutase (SOD) mimetic (18 ± 5 mmHg, n = 9, P < 0.05), that was injected into the arterial supply of the hindlimb. In contrast, the pressor reflex arising from a freely perfused hindlimb (20 ± 3 mmHg) was not attenuated by tempol (17 ± 4 mmHg, n = 10, P = 0.49). Nevertheless, we found no difference in the increase in 8-isoprostaglandin F2α levels, an index of reactive oxygen species, in response to contraction between freely perfused (3.76 ± 0.82 pg/ml, n = 19) and 72-h occluded (3.51 ± 0.92 pg/ml, n = 22, P = 0.90) hindlimbs. Moreover, tempol did not reduce the 8-isoprostaglandin F2α levels during contraction in either group ( P > 0.30). A second SOD mimetic, tiron (200 mg/kg), had no effect on the exercise pressor reflex in either the rats with freely perfused hindlimbs or in those with occluded femoral arteries. These findings suggest that tempol attenuated the exercise pressor reflex in the femoral artery-occluded hindlimb by a mechanism that was independent of its ability to scavenge reactive oxygen species.

scholarly journals Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion

2011 ◽  
Vol 589 (24) ◽  
pp. 6173-6189 ◽  
Author(s):  
Hirotsugu Tsuchimochi ◽  
Katsuya Yamauchi ◽  
Jennifer L. McCord ◽  
Marc P. Kaufman
Keyword(s):  
Ion Channels ◽  
Femoral Artery ◽  
Artery Occlusion ◽  
Exercise Pressor Reflex ◽  
Femoral Artery Occlusion ◽  
Acid Sensing Ion Channels ◽  
Pressor Reflex

scholarly journals Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Hirotsugu Tsuchimochi ◽  
Jennifer L McCord ◽  
Shawn G Hayes ◽  
Satoshi Koba ◽  
Marc P Kaufman
Keyword(s):  
Femoral Artery ◽  
Artery Occlusion ◽  
Exercise Pressor Reflex ◽  
Femoral Artery Occlusion ◽  
Pressor Reflex

scholarly journals PO-126 Inhibition of HIF-1α Alleviates Exaggerated Pressor Response Induced by Static Muscle Contraction in Rats with Peripheral Arterial Disease

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Jianhua Li ◽  
Jihong Xing
Keyword(s):  
Blood Pressure ◽  
Muscle Contraction ◽  
Optical Density ◽  
Femoral Artery ◽  
Pressor Response ◽  
Artery Occlusion ◽  
Reflex Response ◽  
Exercise Pressor Reflex ◽  
Femoral Artery Occlusion ◽  
Pressor Reflex

Objective Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor mediating adaptive responses to hypoxia and ischemia. A prior work showed that HIF-1α is increased in sensory nerves of rats with femoral artery occlusion. The present study was to examine if the reflex response of blood pressure induced by muscle contraction was altered after injection of HIF-1α inhibitor BAY 87-2243 (BAY87) into the arterial blood supply of the ischemic hindlimb muscles.  Methods A rat model of femoral artery ligation was used to study peripheral artery disease. Western blot analysis was employed to examine the protein levels of HIF-1α in the dorsal root ganglion (DRG) tissues. The exercise pressor reflex was evoked by static muscle contraction.  Results HIF-1α was increased in the DRG of occluded limbs (optical density: 0.89±0.13 in control vs. 1.5±0.05 in occlusion; P < 0.05, n=6 in each group). Arterial injection of BAY87 (0.2 mg/kg) inhibited expression of HIF-1α in the DRG of occluded limbs three hours following its injection (optical density: 1.02±0.09 in occluded limbs with BAY87 vs. 1.06±0.1 in control limbs; P > 0.05, n=5 in each group). In addition, muscle contraction evoked a greater increase in blood pressure in occluded rats. BAY87 attenuated the enhanced pressor response in occluded rats to a greater degree than in control rats. Conclusions Inhibition of HIF-1α alleviates exaggeration of the exercise pressor reflex in rats under ischemic circumstances of the hindlimbs induced by femoral artery occlusion.   

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