scholarly journals Hormonal Environment and HER2 Status in Extra-Mammary Paget’s Disease (eMPD): A Systematic Literature Review and Meta-Analysis with Clinical Considerations

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1040
Author(s):  
Giuseppe Angelico ◽  
Angela Santoro ◽  
Frediano Inzani ◽  
Patrizia Straccia ◽  
Damiano Arciuolo ◽  
...  
Keyword(s):  
English Language ◽  
Meta Analysis ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Paget's Disease ◽  
Her2 Status ◽  
Male And Female ◽  
Female Patients ◽  
Language Studies ◽  
Mammary Paget’S Disease

Background. Extra-mammary Paget’s disease (EMPD) is a rare neoplasm of epithelial origin, whose precise incidence is not clear. Starting from what is already known, we performed a systematic review and meta-analysis to investigate in male and female patients the immunohistochemical expression of biological markers that could serve as potential prognostic/therapeutic factors, including only human epidermal growth factor receptor 2 (HER2/neu), Estrogen Receptor (ER), Progesterone Receptor (PR), and Androgen Receptor (AR). Methods. A literature search was performed of the PubMed, Scopus, and Web of Science databases for English-language studies published from January 2000 to June 2020. Results. A total of 27 studies with 713 patients assessed the role of HER2/neu, AR, ER, and PR expression in male and female with EMPD. The overall rate of HER2/neu expression was 30%, the expression’s rate for ER and AR was 13% and 40%, respectively, and the overall rate for PR was 8%. The subgroup analysis revealed that there is a different expression of molecular markers between male and female patients. Conclusions. This study revealed that AR status and HER2/neu overexpression/amplification have been shown as two fundamental pathogenetic pathways in both female and male patients affected by EMPD.

Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

2021 ◽  
pp. 106689692110029
Author(s):  
Kerschen Anja ◽  
Dano Hélène ◽  
Van Eeckhout Pascal ◽  
Marot Liliane ◽  
Van Bockstal Mieke
Keyword(s):  
Present Report ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Cytokeratin 7 ◽  
In Situ Carcinoma ◽  
Epidermal Growth ◽  
Mammary Paget’S Disease

Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.

scholarly journals A case of the maxillary carcinoma with the extra-mammary Paget's disease.

1987 ◽  
Vol 33 (3) ◽  
pp. 566-569
Author(s):  
Junichiro NUKATA ◽  
Tetsuro SUMI ◽  
Masayoshi SAKUDA ◽  
Kazuyoshi TOMITA
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Mammary Paget’S Disease

scholarly journals Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

2021 ◽  
Author(s):  
Ilhame Diboun ◽  
Sachin Wani ◽  
Stuart H Ralston ◽  
Omar M E Albagha
Keyword(s):  
Dna Methylation ◽  
Meta Analysis ◽  
Cpg Islands ◽  
Osteoclast Differentiation ◽  
Paget’S Disease ◽  
Disease Status ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Body Regions

AbstractPaget’s Disease of Bone (PDB) is characterized by focal increases in disorganized bone remodeling. This study aims to characterize PDB associated changes in DNA methylation profiles in patients’ blood. Meta-analysis of data from the discovery and replication set, comprising of 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body regions. These loci, including two characterized as functional through eQTM analysis, were associated with functions related to osteoclast differentiation, mechanical loading, immune function, and viral infection. A multivariate classifier based on discovery samples was found to discriminate PDB cases and controls from the replication with a sensitivity of 0.84, specificity of 0.81, and an area under curve of 92.8%. In conclusion, this study has shown for the first time that epigenetic factors contribute to the pathogenesis of PDB and may offer diagnostic markers for prediction of the disease.

Paget’s Disease of the Vulva: A Review of 20 Years’ Experience

2017 ◽  
Vol 27 (4) ◽  
pp. 791-793 ◽  
Author(s):  
Raghava Parashurama ◽  
Vivek Nama ◽  
Richard Hutson
Keyword(s):  
Local Excision ◽  
Wide Local Excision ◽  
Meta Analysis ◽  
Paget’S Disease ◽  
Rare Condition ◽  
Paget's Disease ◽  
Margin Status ◽  
Recurrence Rates ◽  
Primary Surgery ◽  
Oncology Centre

BackgroundExtramammary Paget’s disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget’s disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Our aim was to review our practice and improve further management of VPD in our center.MethodsWe reviewed all the cases presented to Leeds Gynaecological Oncology Centre between 1988 and 2016. All cases identified in this interval were followed up until April 2016. All case notes and electronic patient data were retrieved to collate the data.ResultsWe identified 18 cases of VPD. The median age at presentation was 76.9 years. Primary surgery was used in 18 cases. Eight patients had wide local excision with graft reconstruction. Ten women had wide local excision with primary reconstruction. Margins were negative in 27% of the excisions. Sixty percent of patients with clear surgical margins had a recurrence, and 69% of patients with positive margins had a recurrence; there was no statistical difference between the 2 groups for recurrence (P > 0.05). Fifty-eight percent of patients who had recurrence had coexisting malignancy. Logistic regression showed no correlation of recurrence rates due to either age, margin status, or coexisting malignancies.ConclusionsPaget’s disease of the vulva is a rare condition. Our experience indicates that most cases may be amenable to surgical treatment at first presentation. Negative margin status does not reduce the chance of recurrence, and hence patients should be under follow-up for life. The benefit of radical surgery in the absence of reduced recurrences, based on margin status, is questionable. Radiotherapy and imiquimod are options for extensive lesions or recurrent settings. Coexisting malignancies are associated with VPD.

scholarly journals Advanced lesions of synchronous bilateral mammary Paget’s disease: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Lina Choridah ◽  
Wida Kartika Sari ◽  
Ery Kus Dwianingsih ◽  
Irianiwati Widodo ◽  
Suwardjo ◽  
...  
Keyword(s):  
Case Report ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Mammary Paget’S Disease
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