Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2

Tyrosine Phosphatase ◽

Specific Protein ◽

Design Synthesis ◽

Protein Tyrosine

Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116418 ◽

2021 ◽

pp. 116418

Author(s):

Mara Ibeth Campos-Almazán ◽

Miguel Flores-Ramos ◽

Alicia Hernández-Campos ◽

Rafael Castillo ◽

Erick Sierra-Campos ◽

...

Keyword(s):

Molecular Dynamics ◽

Tyrosine Phosphatase ◽

Hypoglycemic Effect ◽

Benzimidazole Derivatives ◽

Design Synthesis ◽

Protein Tyrosine

ChemInform Abstract: Design, Synthesis and Biological Activity Evaluation of 2-Mercapto-4(3H)-quinazolinone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B.

ChemInform ◽

10.1002/chin.201249175 ◽

2012 ◽

Vol 43 (49) ◽

pp. no-no

Author(s):

Hui Li ◽

Jin-Ping Wang ◽

Fan Yang ◽

Ting Liu ◽

Wen-Wei Qiu ◽

...

Keyword(s):

Biological Activity ◽

Tyrosine Phosphatase ◽

Design Synthesis ◽

Protein Tyrosine ◽

Activity Evaluation ◽

Quinazolinone Derivatives

Design, Synthesis and Biological Activity Evaluation of 2-Mercapto-4(3H)-quinazolinone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

Heterocycles ◽

10.3987/com-12-12477 ◽

2012 ◽

Vol 85 (8) ◽

pp. 1897 ◽

Cited By ~ 3

Author(s):

Jie Tang ◽

Jia Li ◽

Jin-Ping Wang ◽

Fan Yang ◽

Ting Liu ◽

...

Keyword(s):

Biological Activity ◽

Tyrosine Phosphatase ◽

Design Synthesis ◽

Protein Tyrosine ◽

Activity Evaluation ◽

Quinazolinone Derivatives

Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1664333 ◽

2019 ◽

Vol 38 (13) ◽

pp. 3814-3824 ◽

Cited By ~ 1

Author(s):

Wen-Shan Liu ◽

Rui-Rui Wang ◽

Hai Yue ◽

Zhi-Hui Zheng ◽

Xin-Hua Lu ◽

...

Keyword(s):

Molecular Dynamics ◽

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Design Synthesis ◽

Protein Tyrosine ◽

Ptp1b Inhibitors

Design, synthesis and biological evaluation of novel arylidine-malononitrile derivatives as non-carboxylic inhibitors of protein tyrosine phosphatase 1B

Medicinal Chemistry Research ◽

10.1007/s00044-013-0528-1 ◽

2013 ◽

Vol 22 (11) ◽

pp. 5344-5348 ◽

Cited By ~ 6

Author(s):

Girdhar Singh Deora ◽

Chandrabose Karthikeyan ◽

N. S. Hari Narayana Moorthy ◽

Vandana Rathore ◽

Arun K. Rawat ◽

...

Keyword(s):

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Design Synthesis ◽

Protein Tyrosine ◽

Molecular Dynamics Simulations and Free Energy Calculations of a Novel Series of Protein Tyrosine Phosphatase 1B Difluoromethylenephosphonic Acid Inhibitors

Acta Physico-Chimica Sinica ◽

10.3866/pku.whxb200904271 ◽

2009 ◽

Vol 25 (04) ◽

pp. 668-676

Author(s):

CUI Wei ◽

◽

Keyword(s):

Molecular Dynamics ◽

Free Energy ◽

Molecular Dynamics Simulations ◽

Tyrosine Phosphatase ◽

Free Energy Calculations ◽

Energy Calculations ◽

Protein Tyrosine ◽

Dynamics Simulations

Exploring the allosteric mechanism of protein tyrosine phosphatase 1B by molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1682049 ◽

2019 ◽

Vol 38 (13) ◽

pp. 4040-4047

Author(s):

Quan Wang ◽

Xue-Qi Fu ◽

Qing-Chuan Zheng

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulations ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Allosteric Mechanism ◽

Dynamics Simulations

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Bromophenol Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors.

ChemInform ◽

10.1002/chin.201239087 ◽

2012 ◽

Vol 43 (39) ◽

pp. no-no

Author(s):

Bo Jiang ◽

Dayong Shi ◽

Yongchao Cui ◽

Shuju Guo

Keyword(s):

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Design Synthesis ◽

Protein Tyrosine ◽

Synthesis And Biological Evaluation ◽

Bromophenol Derivatives

Studies of the Mechanism of Selectivity of Protein Tyrosine Phosphatase 1B (PTP1B) Bidentate Inhibitors Using Molecular Dynamics Simulations and Free Energy Calculations

Journal of Chemical Information and Modeling ◽

10.1021/ci800104s ◽

2008 ◽

Vol 48 (10) ◽

pp. 2030-2041 ◽

Cited By ~ 21

Author(s):

Lei Fang ◽

Huai Zhang ◽

Wei Cui ◽

Mingjun Ji

Keyword(s):

Molecular Dynamics ◽

Free Energy ◽

Molecular Dynamics Simulations ◽

Tyrosine Phosphatase ◽

Free Energy Calculations ◽

Energy Calculations ◽

Protein Tyrosine ◽

Dynamics Simulations

Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.08.008 ◽

2010 ◽

Vol 20 (19) ◽

pp. 5732-5734 ◽

Cited By ~ 6

Author(s):

Swati Gupta ◽

Gyanendra Pandey ◽

Neha Rahuja ◽

Arvind K. Srivastava ◽

Anil K. Saxena

Keyword(s):

Tyrosine Phosphatase ◽

Docking Studies ◽

Design Synthesis ◽

Protein Tyrosine