Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity

Abstract [4-14C] Progesterone, fed to leaves and whole plants of Convallaria majalis L., was incorporated into the main cardenolide glycosides. After application of [4-14C] progesterone to the leaves of intact plants via the epidermis labelled desglucocheirotoxin, convallatoxin and convallatoxol were isolated from rhizomes and roots. When the precursor was administered to rhizome cuttings no radioactivity could be detected in the cardiac glycoside fraction. The experiments pointed out that during the stage of flowering biosynthesis of cardenolide glycosides takes place in the leaves of Convallaria majalis rather than in the subterranean parts of the plant. A translocation of these substances from the leaves to rhizomes and roots seems possible.

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Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity

Phytochemistry ◽

10.1016/j.phytochem.2020.112415 ◽

2020 ◽

Vol 176 ◽

pp. 112415

Author(s):

Tomoki Iguchi ◽

Akihito Yokosuka ◽

Naoya Tamura ◽

Shingo Takano ◽

Yoshihiro Mimaki

Keyword(s):

Cytotoxic Activity ◽

Whole Plants

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Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity

Phytochemistry ◽

10.1016/j.phytochem.2014.07.021 ◽

2014 ◽

Vol 107 ◽

pp. 102-110 ◽

Cited By ~ 11

Author(s):

Liying Tang ◽

Zhuju Wang ◽

Hongwei Wu ◽

Akihito Yokosuka ◽

Yoshihiro Mimaki

Keyword(s):

Cytotoxic Activity ◽

Steroidal Glycosides

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Untersuchungen zur Biogenese der Cardenolide in Convallaria majalis L.: Umwandlungen auf der Geninstufe / Cardenolide Biogenesis in Convallaria majalis L.

Zeitschrift für Naturforschung C ◽

10.1515/znc-1978-9-1007 ◽

1978 ◽

Vol 33 (9-10) ◽

pp. 646-650 ◽

Cited By ~ 2

Author(s):

Brigitte Kopp ◽

Wolfgang Löffelhardt ◽

Wolfgang Kubelka

Keyword(s):

Convallaria Majalis ◽

Whole Plants

Abstract [19-3H ] Strophanthidol, fed to leaves of whole plants of Convallaria majalis L., was translocated to the rhizomes and roots. Oxidation to [19-3H] strophanthidin took place in the leaves only. No labelled glycosides of strophanthidol and strophanthidin were found; thus, the aglycones are not precursors of the respective glycosides. It is assumed that the first glycosidation occurs at the C-21 level.

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Cytotoxic activity of steroidal glycosides from the aerial parts of Solanum torvum collected in Thua Thien Hue, Vietnam

Natural Product Research ◽

10.1080/14786419.2020.1788022 ◽

2020 ◽

pp. 1-6

Author(s):

Le Canh Viet Cuong ◽

Le Thi Lien ◽

Nguyen Thi Minh Phuong ◽

Vo Thi Kim Thu ◽

Tran Phuong Ha ◽

...

Keyword(s):

Cytotoxic Activity ◽

Solanum Torvum ◽

Steroidal Glycosides ◽

Aerial Parts

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C 21 steroidal glycosides with cytotoxic activity from Cynanchum taihangense

Phytochemistry Letters ◽

10.1016/j.phytol.2017.05.002 ◽

2017 ◽

Vol 20 ◽

pp. 218-223 ◽

Cited By ~ 3

Author(s):

Yu-Bo Wang ◽

Shan-Shan Su ◽

Shao-Fei Chen ◽

Ming-Xu Tang ◽

Gang Chen ◽

...

Keyword(s):

Cytotoxic Activity ◽

Steroidal Glycosides

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Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from Nervilia concolor

Molecules ◽

10.3390/molecules24142599 ◽

2019 ◽

Vol 24 (14) ◽

pp. 2599

Author(s):

Thi-Ngoc-Mai Tran ◽

Guillaume Bernadat ◽

Dinh-Tri Mai ◽

Van-Kieu Nguyen ◽

Jirapast Sichaem ◽

...

Keyword(s):

Tumor Cell ◽

Cytotoxic Activity ◽

2D Nmr ◽

Side Chain ◽

Tumor Cell Lines ◽

Nmr Data ◽

Cycloartane Glycosides ◽

Whole Plants ◽

Stereogenic Center ◽

Mcf 7

Two new cycloartane glycosides, nervisides I–J, were isolated from Nervilia concolor whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the R configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score. These compounds were tested for cytotoxicity against K562 and MCF-7 tumor cell lines, revealing mild cytotoxic activity.

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