scholarly journals Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma

2020 ◽  
Vol 22 (1) ◽  
pp. 359
Author(s):  
Vladimir Neroev ◽  
Tatyana Malishevskaya ◽  
Dietmar Weinert ◽  
Sergei Astakhov ◽  
Sergey Kolomeichuk ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Body Temperature ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Open Angle Glaucoma ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
High Definition ◽  
Temperature Rhythm ◽  
Alu Repeat

Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of “marker” circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients (p < 0.0001). The 24-h IOP phase correlated with RGC loss (p < 0.0001). The internal phase shift between IOP and body temperature gradually increased with POAG progression (p < 0.001). Angiotensin converting enzyme Alu-repeat deletion/insertion (ACE I/D) emerged as a candidate gene polymorphism, which may play a role in the alteration of the circadian IOP variability in advanced glaucoma. To conclude, a reliable estimation of the 24-h rhythm in IOP requires the degree of RGC damage to be assessed. In advanced POAG, the 24-h phase of IOP tended to occur during the night and correlated with RGC loss, being progressively delayed relative to the phase of temperature.

scholarly journals Decorin Reduces Intraocular Pressure and Retinal Ganglion Cell Loss in Rodents Through Fibrolysis of the Scarred Trabecular Meshwork

2015 ◽  
Vol 56 (6) ◽  
pp. 3743 ◽  
Author(s):  
Lisa J. Hill ◽  
Ben Mead ◽  
Richard J. Blanch ◽  
Zubair Ahmed ◽  
Felicity De Cogan ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Trabecular Meshwork ◽  
Cell Loss ◽  
Retinal Ganglion

scholarly journals Prolonged elevation of intraocular pressure results in retinal ganglion cell loss and abnormal retinal function in mice

2015 ◽  
Vol 130 ◽  
pp. 29-37 ◽  
Author(s):  
A. Kareem Khan ◽  
Dennis Y. Tse ◽  
Meike E. van der Heijden ◽  
Priya Shah ◽  
Derek M. Nusbaum ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Function ◽  
Retinal Ganglion

scholarly journals Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna Y. M. Wang ◽  
Vickie H. Y. Wong ◽  
Pei Ying Lee ◽  
Bang V. Bui ◽  
Stefanie Dudczig ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
P2x7 Receptor ◽  
Field Size ◽  
Multielectrode Arrays ◽  
Retinal Ganglion ◽  
Post Injury ◽  
Genetic Ablation ◽  
Iop Elevation

AbstractThere is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in animal models. In addition, the P2X7-receptor (P2X7-R) has been suggested to contribute to RGC death following stimulation and elevated IOP, though its role in RGC dysfunction prior to death has not been examined. Therefore, we examined the effect of an acute, non-ischemic intraocular pressure (IOP) insult (50 mmHg for 30 min) on RGC function in wildtype mice and P2X7-R knockout (P2X7-KO) mice. We examined retinal function using electroretinogram recordings and individual RGC responses using multielectrode arrays, 3 days following acute IOP elevation. Immunohistochemistry was used to examine RGC cell death and P2X7-R expression in several RGC types. Acute intraocular pressure elevation produced pronounced dysfunction in RGCs; whilst other retinal neuronal responses showed lesser changes. Dysfunction at 3 days post-injury was not associated with RGC loss or changes in receptive field size. However, in wildtype animals, OFF-RGCs showed reduced spontaneous and light-elicited activity. In the P2X7-KO, both ON- and OFF-RGC light-elicited responses were reduced. Expression of P2X7-R in wildtype ON-RGC dendrites was higher than in other RGC types. In conclusion, OFF-RGCs were vulnerable to acute IOP elevation and their dysfunction was not rescued by genetic ablation of P2X7-R. Indeed, knockout of P2X7-R also caused ON-RGC dysfunction. These findings aid our understanding of how pressure affects RGC function and suggest treatments targeting the P2X7-R need to be carefully considered.

scholarly journals Estimation of Retinal Ganglion Cell Loss in Glaucomatous Eyes With a Relative Afferent Pupillary Defect

2014 ◽  
Vol 55 (1) ◽  
pp. 513 ◽  
Author(s):  
Andrew J. Tatham ◽  
Daniel Meira-Freitas ◽  
Robert N. Weinreb ◽  
Amir H. Marvasti ◽  
Linda M. Zangwill ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Relative Afferent Pupillary Defect

scholarly journals Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice

2020 ◽  
Vol 11 (3) ◽  
Author(s):  
Yuki Nakano ◽  
Kazuyuki Hirooka ◽  
Yoichi Chiba ◽  
Masaki Ueno ◽  
Daiki Ojima ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Deficient Mice

scholarly journals Neuroprotective and Anti-Inflammatory Effects of a Hydrophilic Saffron Extract in a Model of Glaucoma

2019 ◽  
Vol 20 (17) ◽  
pp. 4110 ◽  
Author(s):  
Jose A. Fernández-Albarral ◽  
Ana I. Ramírez ◽  
Rosa de Hoz ◽  
Nerea López-Villarín ◽  
Elena Salobrar-García ◽  
...  
Keyword(s):  
Cell Death ◽  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Death ◽  
Saffron Extract ◽  
Anti Inflammatory ◽  
Ganglion Cell Death

Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucomatous damage. Activation of immune cells resident in the retina (microglia) may contribute to RGC death. Thus, a substance with anti-inflammatory activity may protect against RGC degeneration. This study investigated the neuroprotective and anti-inflammatory effects of a hydrophilic saffron extract standardized to 3% crocin content in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Treatment with saffron extract decreased microglion numbers and morphological signs of their activation, including soma size and process retraction, both in OHT and in contralateral eyes. Saffron extract treatment also partially reversed OHT-induced down-regulation of P2RY12. In addition, the extract prevented retinal ganglion cell death in OHT eyes. Oral administration of saffron extract was able to decrease the neuroinflammation associated with increased intraocular pressure, preventing retinal ganglion cell death. Our findings indicate that saffron extract may exert a protective effect in glaucomatous pathology.

scholarly journals Melanopsin retinal ganglion cell loss in A lzheimer disease

2015 ◽  
Vol 79 (1) ◽  
pp. 90-109 ◽  
Author(s):  
Chiara La Morgia ◽  
Fred N. Ross‐Cisneros ◽  
Yosef Koronyo ◽  
Jens Hannibal ◽  
Roberto Gallassi ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Retinal Ganglion

Rapamycin mediates mTOR signaling in reactive astrocytes and reduces retinal ganglion cell loss

2018 ◽  
Vol 176 ◽  
pp. 10-19 ◽  
Author(s):  
Ningfeng Li ◽  
Feifei Wang ◽  
Qinglin Zhang ◽  
Ming Jin ◽  
Ye Lu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Loss ◽  
Reactive Astrocytes ◽  
Mtor Signaling ◽  
Retinal Ganglion
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