scholarly journals RESVEGA, a Nutraceutical Omega-3/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization

2021 ◽  
Vol 22 (20) ◽  
pp. 11023
Author(s):  
Flavie Courtaut ◽  
Virginie Aires ◽  
Niyazi Acar ◽  
Lionel Bretillon ◽  
Ida Chiara Guerrera ◽  
...  

Age-related macular degeneration (AMD) is an eye disease that is characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. At an advanced stage, a blind spot grows in the center of vision, severely handicapping patients with this degenerative condition. Despite therapeutic advances thanks to the use of anti-VEGF, many resistance mechanisms have been found to accentuate the visual deficit. In the present study, we explored whether supplementation with Resvega®, a nutraceutical formulation composed of omega-3 fatty acids and resveratrol, a well-known polyphenol in grapes, was able to counteract laser-induced choroidal neovascularization (CNV) in mice. We highlight that Resvega® significantly reduced CNV in mice compared with supplementations containing omega-3 or resveratrol alone. Moreover, a proteomic approach confirmed that Resvega® could counteract the progression of AMD through a pleiotropic effect targeting key regulators of neoangiogenesis in retina cells in vivo. These events were associated with an accumulation of resveratrol metabolites within the retina. Therefore, a supplementation of omega-3/resveratrol could improve the management or slow the progression of AMD in patients with this condition.

2021 ◽  
Vol 11 (7) ◽  
Author(s):  
Niyazi Acar ◽  
Bénédicte M. J. Merle ◽  
Soufiane Ajana ◽  
Zhiguo He ◽  
Stéphane Grégoire ◽  
...  

2020 ◽  
Vol 7 (5) ◽  
pp. 835-837 ◽  
Author(s):  
Changyang Zhou ◽  
Xinde Hu ◽  
Cheng Tang ◽  
Wenjia Liu ◽  
Shaoran Wang ◽  
...  

Summary RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration.


2015 ◽  
Vol 55 (2) ◽  
pp. 62-69 ◽  
Author(s):  
Eric H. Souied ◽  
Tariq Aslam ◽  
Alfredo Garcia-Layana ◽  
Frank G. Holz ◽  
Anita Leys ◽  
...  

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