Mobility Patterns and Mode Choice Preferences during the COVID-19 Situation

The empirical research on the COVID-19 epidemic’s consequences suggests a major drop in human mobility and a significant shift in travel patterns across all forms of transportation. We can observe a shift from public transport and an increase in car use, and in some cases also increase of cycling and (less often) walking. Furthermore, it seems that micromobility and, more generally, environmentally friendly and comanaged mobility (including shared services), are gaining ground. In previous research, much attention was paid to the mode choice preferences during lockdown, or early stages of the SARS-CoV-2 situation. The blind spot, and aim of this work, is how long observed changes in mode choice last and when or if we can expect the mode choice to shift back to the situation before the SARS-CoV-2 episodes. The research sample consisted of 636 cases; in total, 10 countries contributed to the sample examined in this study. The data were collected in two phases: the first in the spring of 2020 and the second in the fall of the same year. Results showed that respondents reduced mobility by car, local public transport and walking, but not bicycling during the lockdown, compared to the time before the pandemic started. When the easing came, respondents assessed their own use of the car and walking as almost back to normal. They also reported an increase in the use of public transport, but not reaching the level prior the pandemic by far. It seems that cycling was affected least by the pandemic; use of a bicycle hardly changed at all. As for the implication of our study, it is evident that special attention and actions will be needed to bring citizens back to public transport, as it seems that the impact of the pandemic on public transport use will last much longer than the pandemic itself.

Targeted Memory Reactivation during Mind-Wandering in Younger and Older Adults

Mind-wandering (MW) is a universal cognitive process that is estimated to comprise ~30% of our everyday thoughts. Despite its prevalence, the functional utility of MW remains a scientific blind spot. The present study sought to investigate whether MW serves a functional role in cognition. Specifically, we investigated whether MW contributes to memory consolidation processes, and if age differences in the ability to reactivate episodic memories during MW may contribute to age-related declines in episodic memory. Younger and older adults encoded paired associates, received targeted reactivation cues during an interval filled with a task which promotes MW, and were tested on their memory for the cued and uncued stimuli from the initial encoding task. Thought probes were presented during the retention (MW) interval to assess participants’ thought contents. Across three experiments, we compared the effect of different cue modalities (i.e., auditory, visual) on cued recall performance, and examined both correct retrieval response times as well as accuracy. Across experiments, there was evidence that stimuli that were cued during the MW task were correctly retrieved more quickly than uncued stimuli and that this effect was more robust for younger adults than older adults. Additionally, the more MW a participant reported during the retention interval, the stronger the cueing effect they produced during retrieval. The results from these experiments are interpreted within a retrieval facilitation framework wherein cues serve to reactivate the earlier traces during MW, and this reactivation benefits retrieval speed for cued items as compared to uncued items.

Experimental Characterization of the Hepatitis B Virus Capsid Dynamics by Solid-State NMR

Protein plasticity and dynamics are important aspects of their function. Here we use solid-state NMR to experimentally characterize the dynamics of the 3.5 MDa hepatitis B virus (HBV) capsid, assembled from 240 copies of the Cp149 core protein. We measure both T1 and T1ρ relaxation times, which we use to establish detectors on the nanosecond and microsecond timescale. We compare our results to those from a 1 microsecond all-atom Molecular Dynamics (MD) simulation trajectory for the capsid. We show that, for the constituent residues, nanosecond dynamics are faithfully captured by the MD simulation. The calculated values can be used in good approximation for the NMR-non-detected residues, as well as to extrapolate into the range between the nanosecond and microsecond dynamics, where NMR has a blind spot at the current state of technology. Slower motions on the microsecond timescale are difficult to characterize by all-atom MD simulations owing to computational expense, but are readily accessed by NMR. The two methods are, thus, complementary, and a combination thereof can reliably characterize motions covering correlation times up to a few microseconds.

Obedient rebellion: conceiving the African nuclear weapon-free zone

Why do nuclear weapon-free zones (NWFZs)—areas which prohibit nuclear weapons—emerge in some contexts, and not others? Focusing on the African case, this article introduces the concept of ‘obedient rebellion’ to explain the African NWFZ's early conception. ‘Obedient rebellion’ is an attitude of ambivalence toward global nuclear order. To newly-decolonizing African states, the African NWFZ symbolized both postcolonial anti-nuclear solidarity and nuclear responsibility; it represented both ‘obedience’ to—and ‘rebellion’ against—global nuclear order. This ambivalence, between ‘obedience’ and ‘rebellion’, paradoxically accommodated multiple conflicting audiences simultaneously, thereby stabilising the zone. The African NWFZ's ambiguous meanings made it viable, even though those meanings conflicted. The zone's early conception offers insight into the complex, contending forces that continue to bind the world's NWFZs—and indeed nuclear order itself—to the present. NWFZs epitomize the tensions which stabilize nuclear order: between sovereign equality and nuclear inequality; between local solidarities and global loyalties; and between contestation and compromise. At first, these tensions seem to imperil NWFZs; in fact, these tensions stabilize NWFZs. The African zone also poses challenges to the African blind spot that continues to exist in International Relations theory.

Studying insecurity from relative safety — Dealing with methodological blind spots

Qualitative empirical enquiries into dynamics of security and insecurity often include a blind spot that bear theoretical ramifications because only those areas and respondents that allow for relatively safe fieldwork are studied. To transparently articulate the spheres of projection that creep into our knowledge production, we propose a distinction between inner and outer circles as highly fluid but separate geographical, socio-political and methodological spaces. Drawing on fieldwork in the Central African Republic and South Sudan, we discuss the risks posed by incomplete data and subsequently flawed inferences. We argue that the perceptions of fear projected onto the outer circle shape people’s behaviour more than measurable insecurity incidents and that increased interaction between actors in both circles reduces the perceived threats coming from the outer circles. We demonstrate how studying insecurity from inner circles risks securitizing outer circles while further centralizing the inner ones. We thus urge transparency in data collection and the related inferences that underpin our knowledge production.

In vivo identification and validation of novel potential predictors for human cardiovascular diseases

Genetics crucially contributes to cardiovascular diseases (CVDs), the global leading cause of death. Since the majority of CVDs can be prevented by early intervention there is a high demand for the identification of predictive causative genes. While genome wide association studies (GWAS) correlate genes and CVDs after diagnosis and provide a valuable resource for such causative candidate genes, often preferentially those with previously known or suspected function are addressed further. To tackle the unaddressed blind spot of understudied genes, we particularly focused on the validation of human heart phenotype-associated GWAS candidates with little or no apparent connection to cardiac function. Building on the conservation of basic heart function and underlying genetics from fish to human we combined CRISPR/Cas9 genome editing of the orthologs of human GWAS candidates in isogenic medaka with automated high-throughput heart rate analysis. Our functional analyses of understudied human candidates uncovered a prominent fraction of heart rate associated genes from adult human patients impacting on the heart rate in embryonic medaka already in the injected generation. Following this pipeline, we identified 16 GWAS candidates with potential diagnostic and predictive power for human CVDs.

Mary Astell on the Social Nature of the Cartesian Passions

Scholars have long recognised that Mary Astell builds her feminist critique of society on a foundation of Cartesian views about human nature and the passions. At the same time, the full extent of the influence of Descartes’ view of embodiment on the solution Astell proposes in her Serious Proposal to the Ladies is only beginning to come to light. In this paper, I contribute to this ongoing project by arguing that Astell builds on Descartes’ ideas by addressing a blind spot in his view, namely, that that the embodied self is socially situated, and that therefore, our social context plays a crucial formative role in the development of our passions. In doing so, I show Astell extends Cartesian philosophy beyond an egalitarian feminist critique of society, but also to a positive political theory offering a solution to the problems she identifies. Thusly, Astell shows the political potential of Cartesian philosophy as a framework for social critique and to seek solutions to the problems such a critique can bring out.

Impact of Computer-Assisted System on the Learning Curve and Quality in Esophagogastroduodenoscopy: Randomized Controlled Trial

Background and Aims: To investigate the impact of the computer-assisted system on esophagogastroduodenoscopy (EGD) training for novice trainees in a prospective randomized controlled trial.Methods: We have constructed a computer-aided system (CAD) using retrospective images based on deep learning which could automatically monitor the 26 anatomical landmarks of the upper digestive tract and document standard photos. Six novice trainees were allocated and grouped into the CAD group and control group. Each of them took the training course, pre and post-test, and EGD examination scored by two experts. The CAD group was trained with the assistance of the CAD system and the control group without.Results: Both groups achieved great improvements in EGD skills. The CAD group received a higher examination grading score in the EGD examination (72.83 ± 16.12 vs. 67.26 ± 15.64, p = 0.039), especially in the mucosa observation (26.40 ± 6.13 vs. 24.11 ± 6.21, p = 0.020) and quality of collected images (7.29 ± 1.09 vs. 6.70 ± 1.05). The CAD showed a lower blind spot rate (2.19 ± 2.28 vs. 3.92 ± 3.30, p = 0.008) compared with the control group.Conclusion: The artificial intelligence assistant system displayed assistant capacity on standard EGD training, and assisted trainees in achieving a learning curve with high operation quality, which has great potential for application.Clinical Trial Registration: This trial is registered at https:/clinicaltrials.gov/, number NCT04682821.

Diversity, Identity, Oppression: The Construction of “Blackness” in Dear White People

In the series Dear White People (DWP), students at the fictional University of Winchester struggle for racial justice. We analyze how the series treats “race” and racism and how this relates to contemporary debates in the United States. While the series presents an imaginary environment, we recognize strong similarities to actual student life and students grappling with various experiences of oppression including sexual violence. We draw on theories of identity formation (Margalit and Raz; Vondermaßen; Young) and intersectionality (Crenshaw; Collins) to uncover how the series portrays and complicates “Blackness” as an identity-forming experience and as an experience shaped by converging forms of structural discrimination. While we highlight the merit of combining two theoretical approaches (one of identity formation and one of oppression), we note that especially intersectionality helped uncover a major blind spot of the series. Although Black women are at the center of the series and the struggle for racial equality at Winchester, their particular experiences of violence are marginalized in seasons 1–3. This tendency to overlook the experiences of Black women reflects the larger debate around race, racism, and movements for social justice.