scholarly journals Treatment with Mesenchymal Stromal Cells Overexpressing Fas-Ligand Ameliorates Acute Graft-versus-Host Disease in Mice

2022 ◽  
Vol 23 (1) ◽  
pp. 534
Author(s):  
Andrei Mircea Vacaru ◽  
Ana-Maria Mazilu ◽  
Madalina Dumitrescu ◽  
Ioana Madalina Fenyo ◽  
Anca Violeta Gafencu ◽  
...  

Allogeneic hematopoietic cell transplantation (allo-HCT) has the potential to cure malignant and non-malignant hematological disorders, but because of the serious side effects of this intervention its applications are limited to a restricted number of diseases. Graft-versus-host disease (GvHD) is the most frequent complication and the leading cause of mortality and morbidity following allo-HCT. It results from the attack of the transplanted T cells from the graft against the cells of the recipient. There is no clear treatment for this severe complication. Due to their immunomodulatory properties, mesenchymal stromal cells (MSC) have been proposed to treat GvHD, but the results did not meet expectations. We have previously showed that the immunomodulatory effect of the MSC was significantly enhanced through adenoviral-mediated overexpression of FasL. In this study, we have tested the properties of FasL-overexpressing MSC in vivo, in a mouse model for acute GvHD. We found that treatment with FasL-overexpressing MSC delayed the onset of the disease and increased survival of the mice.

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S224
Author(s):  
J Keto ◽  
T Kaartinen ◽  
U Salmenniemi ◽  
J Partanen ◽  
A Hänninen ◽  
...  

2013 ◽  
Vol 55 (5) ◽  
pp. 1203-1205 ◽  
Author(s):  
Lucia Silla ◽  
Vanessa Valim ◽  
Bruna Amorin ◽  
Ana Paula Alegretti ◽  
Fernanda dos Santos de Oliveira ◽  
...  

2019 ◽  
Vol 185 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Antonio Galleu ◽  
Dragana Milojkovic ◽  
Simona Deplano ◽  
Richard Szydlo ◽  
Sandra Loaiza ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document