scholarly journals Adherence to Immunosuppression Medications among Heart Transplant Recipients: Challenges, Opportunities, and Potential Role of Digital Approaches in the COVID-19 Era

2021 ◽  
Vol 8 (6) ◽  
pp. 68
Author(s):  
Tasmeen Hussain ◽  
Keira Nassetta ◽  
Sherif M. Badawy
Keyword(s):  
Heart Transplant ◽  
Potential Role ◽  
Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Adherence Behavior ◽  
Unique Challenge ◽  
Heart Transplant Recipients

Society and medical practice have been restructured dramatically to avoid further spread of the COVID-19 virus; telehealth/telemedicine, mask wearing, and nationwide social distancing practices have become widespread. However, we still face unprecedented challenges in fields where patients require frequent and active follow-up visits for monitoring, including that of solid-organ transplant, and in particular, heart transplant. Adherence to immunosuppression remains a unique challenge in heart transplantation, especially during the COVID-19 pandemic. Failure to adhere to immunosuppression can have disastrous consequences, including graft rejection and death. In this article, we discuss challenges related to adherence to immunosuppression medications among heart transplant recipients, as well as opportunities to leverage digital approaches and interventions to monitor and optimize adherence behavior and health outcomes in this population.

The Potential Role of T-Cell Memory Distribution as Predisposing Factor for Rejection in Heart Transplant Recipients

2009 ◽  
Vol 41 (6) ◽  
pp. 2480-2484 ◽  
Author(s):  
N. Lanio ◽  
E. Sarmiento ◽  
A. Gallego ◽  
J. Fernández-Yánez ◽  
J. Palomo ◽  
...  
Keyword(s):  
T Cell ◽  
Heart Transplant ◽  
Potential Role ◽  
T Cell Memory ◽  
Transplant Recipients ◽  
Cell Memory ◽  
Predisposing Factor ◽  
Heart Transplant Recipients

Role of dietary intervention and nutritional follow-up in heart transplant recipients

2009 ◽  
Vol 23 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Bruna Guida ◽  
Nunzia Ruggiero Perrino ◽  
Roberta Laccetti ◽  
Rossella Trio ◽  
Annamaria Nastasi ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Dietary Intervention ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

scholarly journals Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Vincent Tchana-Sato ◽  
Arnaud Ancion ◽  
Julien Tridetti ◽  
Natzi Sakalihasan ◽  
Marie Pierre Hayette ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Clinical Course ◽  
Case Reports ◽  
Organ Transplant ◽  
Case Series ◽  
Perioperative Period ◽  
Severe Form ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

Abstract Background There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed.

scholarly journals Clinical course and challenging management of early COVID-19 infection after heart transplantation: Case report of two patients

2020 ◽  
Author(s):  
Vincent Tchana-Sato ◽  
Arnaud Ancion ◽  
Julien Tridetti ◽  
Natzi Sakalihasan ◽  
Marie pierre Hayette ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Clinical Course ◽  
Asymptomatic Carrier ◽  
Case Reports ◽  
Organ Transplant ◽  
Case Series ◽  
Perioperative Period ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Heart Transplant Recipients

Abstract Background: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients and especially in heart transplant recipients with only few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplants recipients who were tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease, and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions: These two cases illustrate the severity and the poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory and the issue of asymptomatic carrier need to be addressed.

scholarly journals Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Farah Naghashzadeh ◽  
Shadi Shafaghi ◽  
Babak Sharif-Kashani ◽  
Payam Tabarsi ◽  
Leila Saliminejad ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Organ Transplant ◽  
Case Series ◽  
Outpatient Setting ◽  
Clinical Severity ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Treatment Data ◽  
Heart Transplant Recipients

Abstract Background With the rapidly expanding pandemic of severe acute respiratory syndrome coronavirus-2, a chronic immunosuppressed state in solid organ transplant recipients is a concern. We reported coronavirus disease 2019 in heart transplant recipients and described the patients’ course from diagnosis to either hospital admission or improvement in symptoms. Case presentation This study retrospectively identified 13 white (Iranian) heart transplant patients with coronavirus disease 2019 between December 2019 and October 2020. The mean age of patients was 43.7 years (19–65 years); seven (70%) were men. Laboratory and treatment data were collected for those admitted or managed as outpatients. Outcomes were also recorded for all patients. This report demonstrates a range of symptoms, clinical severity, and disease course in heart transplant recipients with coronavirus disease 2019, including ten hospitalized patients and three patients, managed entirely in the outpatient setting. One patient passed away, and none of them experienced an episode of clinically overt rejection. Conclusions We would like to emphasize the importance of being alert in these patients to consider testing in a broad range of clinical presentations and gathering more data for better management.

scholarly journals Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Christina Wlodek ◽  
Faisal R. Ali ◽  
John T. Lear
Keyword(s):  
Photodynamic Therapy ◽  
Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Actinic Keratoses ◽  
Organ Transplant Recipients ◽  
Skin Cancers ◽  
Effective Treatment Modality ◽  
Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

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